Physiological economy in nutrition, with special reference to the minimal proteid requirement of the healthy man an experimental study

Part 4

Chapter 42,068 wordsPublic domain

+-----------+-------+--------------------------------------------------+ | | | | | | | Urine. | | | | | | Date. | Body- +-------+------+-----------+-----------+-----------+ | |weight.|Volume.| Sp. | Nitrogen. | Uric Acid.| P₂O₅. | | | | 24 | Gr. | | | | | | |hours. | | | | | +-----------+-------+-------+------+-----------+-----------+-----------+ | 1903 | kilos | c.c. | | grams | gram | grams | | | | | | | | | | Oct. 13 | 57.5 | 380 | 1027 | 5.46 | 0.376 | 1.10 | | 14 | | 550 | 1027 | 6.51 | | | | 15 | | 400 | 1022 | 5.40 | 0.352 | 1.02 | | 16 | | 500 | 1027 | 6.45 | | | | 17 | 57.4 | 477 | 1030 | 6.40 | | | | 18 | | 670 | 1027 | 7.20 | 0.406 | 1.10 | | 19 | | 435 | 1027 | 6.13 | | | | 20 | | 465 | 1028 | 6.83 | 0.476 | 0.92 | | 21 | | 450 | 1029 | 6.51 | | | | 22 | | 465 | 1027 | 6.14 | 0.370 | 0.96 | | 27 | | 445 | 1023 | 5.52 | 0.385 | 0.79 | | 28 | | 405 | 1027 | 5.08 | | | | Nov. 1 | | 390 | 1029 | 5.68 | 0.372 | 0.42 | | 2 | | 530 | 1027 | 6.33 | | | | 3 | | 470 | 1027 | 5.92 | 0.412 | 0.75 | | 4 | | 425 | 1028 | 5.88 | | | | 5 | | 375 | 1029 | 4.93 | 0.330 | 0.79 | | 7 | | 545 | 1028 | 6.57 | | | | 8 | 57.4 | 456 | 1029 | 5.82 | 0.371 | 0.65 | | 9 | | 415 | 1027 | 5.43 | | | | 10 | | 615 | 1025 | 6.45 | 0.430 | 1.17 | | 11 | | 410 | 1028 | 4.80 | | | | 12 | | 580 | 1026 | 5.64 | 0.371 | 1.02 | | 13 | | 584 | 1027 | 5.82 | | | | 14 | | 505 | 1029 | 6.36 | | | | 15 | | 405 | 1028 | 5.80 | 0.384 | 0.73 | | 16 | | 425 | 1027 | 5.43 | | | | 17 | | 455 | 1028 | 5.27 | 0.367 | 0.76 | | 18 | | 575 | 1027 | 6.62 | | | | 19 | | 447 | 1027 | 5.34 | 0.389 | 0.77 | | 20 | | 480 | 1029 | 6.00 | | | | 21 | 57.5 | 400 | 1029 | 5.71 | | | | 22 | | 382 | 1029 | 5.52 | 0.379 | 0.97 | | 23 | 57.7 | 350 | 1029 | 5.33 | | | | 24 | | 422 | 1029 | 6.43 | 0.400 | | | 25 | | 435 | 1030 | 5.79 | | | | 26 | 57.6 | 445 | 1030 | 6.09 | 0.430 | 1.01 | | 27 | | 430 | 1030 | 6.17 | | | | 29 | | 454 | 1027 | 5.66 | 0.420 | 0.93 | | 30 | | 455 | 1023 | 5.56 | | | | Dec. 1 | | 420 | 1028 | 5.31 | 0.450 | 0.92 | | 2 | | 465 | 1027 | 6.17 | | | | 3 | | 430 | 1027 | 5.34 | 0.350 | 0.82 | | 4 | | 365 | 1029 | 4.77 | | | | 5 | | 430 | 1030 | 5.83 | | | | 6 | | 515 | 1028 | 5.90 | 0.393 | 1.08 | | 7 | | 400 | 1028 | 5.57 | | | | 8 | | 390 | 1028 | 4.99 | 0.328 | 1.02 | | 9 | | 405 | 1030 | 5.17 | | | | 10 | 57.6 | 370 | 1026 | 4.64 | 0.308 | 0.90 | | 11 | | 327 | 1030 | 4.65 | 0.325 | 1.11 | | 12 | | 390 | 1027 | 5.16 | 0.346 | 1.01 | | 13 | | 429 | 1029 | 5.66 | | | | 14 | | 360 | 1030 | 4.84 | | | | 15 | | 295 | 1029 | 4.32 | 0.291 | 0.82 | | 16 | | 445 | 1029 | 6.27 | | | | 17 | | 390 | 1032 | 5.59 | 0.358 | 0.73 | | 18 | | 420 | 1030 | 5.62 | | | | 19 | | 415 | 1027 | 5.03 | | | | 20 | 57.5 | 390 | 1030 | 5.71 | 0.402 | 0.78 | | 21 | | 360 | 1023 | 4.25 | | | | 22 | | 360 | 1030 | 5.13 | 0.342 | 0.79 | | 23 | | 400 | 1031 | 5.08 | | | | 24 | | 435 | 1030 | 6.44 | | | | 25 | | 450 | 1029 | 5.13 | 0.329 | 0.77 | | 26 | | 465 | | 5.55 | | | | 27 | | 470 | | 5.53 | | | | 28 | | 535 | | 8.18 | | | | 29 | | 535 | | 7.67 | | | | 30 | | 656 | | 9.68 | | | | 31 | 57.6 | 490 | 1031 | 7.61 | 0.455 | 0.92 | | 1904 | | | | | | | | Jan. 1 | | 415 | 1030 | 6.41 | | | | 2 | | 490 | 1031 | 6.56 | | | | 3 | | 460 | 1030 | 5.91 | 0.319 | 0.79 | | 4 | 58.1 | 430 | 1030 | 5.72 | | | | 5 | | 570 | 1028 | 6.36 | 0.402 | | | 6 | | 445 | 1028 | 5.68 | | | | 7 | | 510 | 1028 | 5.91 | 0.367 | 0.99 | | 8 | | 420 | 1028 | 5.37 | | | | 9 | | 650 | 1027 | 7.29 | | | | 10 | | 635 | 1024 | 6.32 | 0.414 | 0.99 | | 11 | | 410 | 1028 | 4.87 | | | | 12 | | 450 | 1027 | 6.48 | | | | 13 | | 410 | 1027 | 5.34 | 0.435 | | | 14 | | 532 | 1028 | 6.22 | 0.502 | | | 15 | | 530 | 1028 | 5.98 | | | | 16 | | 515 | 1030 | 6.18 | | | | 17 | | 537 | 1030 | 6.73 | 0.429 | | | 18 | 57.8 | 395 | 1029 | 5.09 | | | | 19 | | 450 | 1030 | 5.72 | 0.427 | | | 20 | | 420 | 1026 | 4.76 | | | | 21 | | 410 | 1029 | 5.26 | 0.401 | | | 22 | | 485 | 1029 | 5.41 | | | | 23 | | 440 | 1031 | 5.07 | | | | 24 | | 485 | 1029 | 5.61 | 0.407 | | | 25 | | 545 | 1027 | 6.18 | | | | 26 | | 485 | 1028 | 6.69 | 0.440 | | | 27 | | 435 | 1028 | 5.64 | | | | 28 | | 490 | 1029 | 6.18 | 0.423 | | | 29 | | 450 | 1029 | 5.68 | | | | 30 | | 475 | | 5.59 | 0.376 | | | 31 | | 490 | | 6.61 | | | | Feb. 1 | | 490 | 1030 | 6.47 | | | | 2 | 57.5 | 400 | 1031 | 6.12 | 0.219 | | | 3 | | 415 | 1030 | 5.85 | | | | 4 | | 545 | 1027 | 6.77 | 0.327 | | | 5 | | 450 | 1030 | 5.64 | | | | 6 | | 485 | 1027 | 6.01 | | | | 7 | | 450 | 1026 | 5.62 | | | | 8 | 57.4 | 415 | 1027 | 5.88 | | | | 9 | | 540 | 1026 | 6.67 | 0.449 | | | 10 | | 410 | 1029 | 5.61 | | | | 11 | | 600 | 1025 | 6.70 | | | | 12 | | 430 | 1029 | 5.57 | 0.437 | | | 13 | | 415 | 1028 | 5.50 | | | | 14 | | 480 | 1028 | 6.42 | 0.497 | | | 15 | | 395 | 1030 | 4.95 | | | | 16 | | 500 | 1029 | 5.97 | 0.364 | | | 17 | | 450 | 1030 | 5.62 | | | | 18 | 57.3 | 430 | 1030 | 5.86 | 0.279 | | | 19 | | 450 | 1029 | 6.21 | | | | 20 | | 455 | 1027 | 5.46 | | | | 21 | | 500 | 1027 | 6.16 | 0.424 | | | 22 | | 445 | 1028 | 5.15 | | | | 23 | | 455 | 1027 | 5.63 | | | | 24 | | 420 | 1028 | 6.27 | | | | 25 | | 560 | 1027 | 6.28 | 0.403 | | | 26 | | 630 | 1026 | 6.27 | | | | 27 | | 570 | 1026 | 6.87 | | | | 28 | | 515 | 1028 | 6.27 | 0.496 | | | 29 | | 450 | 1030 | 5.43 | | | | Mar. 1 | | 450 | 1027 | 6.02 | | | | 2 | | 445 | 1029 | 5.15 | | | | 3 | | 590 | 1028 | 6.30 | | | | 4 | | 415 | 1029 | 5.40 | | | | 5 | 57.5 | 425 | 1027 | 5.48 | | | | 6 | | 548 | 1025 | 5.92 | 0.370 | | | 7 | | 400 | 1029 | 4.68 | | | | 8 | | 530 | 1028 | 5.77 | | | | 9 | | 560 | 1028 | 5.84 | | | | 10 | | 560 | 1028 | 5.64 | | | | 11 | | 495 | 1028 | 5.79 | | | | 12 | | 515 | 1021 | 6.80 | | | | 13 | | 520 | 1029 | 6.43 | 0.370 | | | 14 | | 600 | 1025 | 6.12 | | | | 15 | | 520 | 1026 | 5.87 | | | | 16 | 57.5 | 525 | 1026 | 5.13 | | | | 17 | | 490 | 1026 | 4.97 | | | | 18 | | 450 | 1027 | 5.08 | | | | 19 | | 500 | 1024 | 5.85 | | | | 20 | | 500 | 1022 | 5.91 |⎫ | | | 21 | 57.4 | 430 | 1025 | 5.52 |⎪ | | | 22 | | 458 | 1033 | 5.94 |⎪ | | | 23 | 57.2 | 400 | 1029 | 5.61 |⎬ 0.321 | 1.20 | | 24 | 57.3 | 365 | 1029 | 4.31 |⎪ daily | daily | | 25 | | 420 | 1029 | 5.39 |⎭ average | average | | 26 | 57.5 | 435 | 1027 | 5.85 | | | | 27 | | 595 | 1026 | 6.33 | | | | 28 | | 545 | 1027 | 6.00 | | | | 29 | | 435 | 1028 | 4.86 | | | | 30 | | 575 | 1026 | 6.26 | | | | 31 | | 495 | 1026 | 5.26 | | | | Apr. 1 | | 570 | 1026 | 6.33 | | | | 2 | | 440 | 1030 | 6.07 | | | | 3 | | 487 | 1026 | 6.11 | 0.375 | | | 4 | | 410 | 1028 | 5.78 | | | | 5 | | 390 | 1028 | 5.38 | | | | 6 | 56.8 | 490 | 1028 | 5.56 | | | | 7 | 56.5 | 530 | 1027 | 5.69 | | | | 8 | | 440 | 1029 | 5.41 | | | | 9 | | 465 | 1019 | 6.05 | | | | 10 | 56.8 | 500 | 1029 | 6.00 | 0.382 | | | 11 | | 500 | 1028 | 6.18 | | | | 12 | 56.4 | 475 | 1029 | 5.55 | 0.366 | 0.870 | +-----------+-------+-------+------+-----------+-----------+-----------+ |Daily average for | | | | | | | six months | 466 | 1027 | 5.82 | 0.386 | 0.899 | +-----------+-------+-------+------+-----------+-----------+-----------+ | 13 | | 545 | 1029 | 6.77 | | | | 14 | | 440 | 1027 | 5.89 | | | | 15 | | 500 | 1028 | 5.91 | | | | 16 | | 485 | 1028 | 5.49 | | | | 17 | | 405 | 1029 | 5.99 | 0.393 | | | 18 | | 465 | 1029 | 6.11 | | | | 19 | | 510 | 1030 | 7.68 | | | | 20 | | 430 | 1031 | 6.99 | | | | 21 | 56.6 | 615 | 1029 | 8.67 | | | | 22 | | 320 | 1030 | 5.03 | | | | 23 | 57.1 | 355 | 1032 | 5.72 | | | | 24 | | 455 | 1027 | 5.97 | | | | 25 | | 380 | 1027 | 4.93 | | | | 26 | | 450 | 1028 | 4.97 | 0.366 | | | 27 | | 600 | 1025 | 6.62 | 0.553 | | | 28 | 56.9 | 385 | 1029 | 5.66 | 0.507 | | | 29 | | 415 | 1029 | 5.28 | 0.488 | | | 30 | 56.9 | 462 | 1029 | 5.59 | 0.413 | | | May 1 | | 486 | 1027 | 5.54 | 0.409 | | | 2 | | 405 | 1028 | 4.11 | 0.320 | | | 3 | 57.1 | 505 | 1027 | 5.48 | | | | 4 | | 456 | 1026 | 5.27 | | | | 5 | | 380 | 1026 | 4.88 | | | | 6 | | 530 | 1027 | 6.30 | | | | 7 | | 470 | 1024 | 5.44 | | | | 8 | 57.6 | 460 | 1027 | 5.07 | | | | 9 | | 460 | 1026 | 4.28 | | | | 10 | 57.4 | 493 | 1028 | 5.26 | | | | 11 | | 415 | 1029 | 4.61 | | | | 12 | | 530 | 1029 | 5.98 | | | | 13 | | 415 | 1031 | 4.72 | | | | 14 | 57.2 | 405 | 1031 | 4.98 | 0.468 | | | 15 | | 500 | 1029 | 5.31 | | | | 16 | | 505 | 1027 | 5.03 | | | | 17 | | 650 | 1020 | 5.69 | | | | 18 | | 550 | 1027 | 5.81 | | | | 19 | | 560 | 1027 | 6.05 | | | | 20 | | 615 | 1027 | 6.64 | | | | 21 | 56.9 | 380 | 1032 | 5.20 | 0.421 | | | 22 | | 475 | 1028 | 5.73 | | | | 23 | | 378 | 1028 | 4.60 | | | | 24 | | 383 | 1029 | 4.48 | | | | 25 | | 535 | 1025 | 5.14 | | | | 26 | 56.9 | 355 | 1028 | 4.37 | | | | 27 | | 435 | 1026 | 4.93 | | | | 28 | 57.5 | 555 | 1028 | 5.99 | 0.397 | | | 29 | 57.7 | 565 | 1027 | 6.27 | | | | 30 | | 700 | 1020 | 5.50 | | | | 31 | | 500 | 1025 | 5.13 | | | | June 1 | | 630 | 1023 | 5.41 | | | | 2 | | 510 | 1020 | 4.16 | | | | 3 | | 530 | 1023 | 5.25 | | | | 4 | 57.6 | 390 | 1029 | 5.25 | | | | 5 | | 400 | 1025 | 4.87 | | | | 6 | | 430 | 1027 | 5.16 | | | | 7 | | 480 | 1028 | 5.15 | | | | 8 | | 410 | 1027 | 4.95 | | | | 9 | | 420 | 1026 | 4.51 | | | | 10 | | 395 | 1026 | 4.27 | | | | 11 | 57.5 | 510 | 1030 | 5.91 | | | | 12 | | 530 | 1027 | 5.95 | | | | 13 | 57.6 | 485 | 1027 | 5.35 | | | | 14 | | 470 | 1030 | 5.16 | | | | 15 | | 560 | 1024 | 4.91 | | | | 16 | 57.6 | 390 | 1029 | 5.26 | | | | 17 | | 408 | 1027 | 5.17 | | | | 18 | 57.9 | 412 | 1030 | 5.07 | | | | 19 | | 458 | 1025 | 5.44 | | | | 20 | 58.0 | 380 | 1026 | 4.49 | | | | 21 | | 480 | 1023 | 5.04 | | | | 22 | 57.8 | 580 | 1025 | 6.16 | | | | 23 | 57.9 | 535 | 1025 | 5.26 |⎫ | | | 24 | 57.6 | 570 | 1024 | 5.30 |⎪ | | | 25 | | 410 | 1027 | 4.43 |⎬ 0.397 | 1.08 | | 26 | 57.4 | 400 | 1027 | 4.66 |⎪ daily | daily | | 27 | 57.4 | 405 | 1027 | 4.98 |⎭ average | average | +-----------+-------+-------+------+-----------+-----------+-----------+ |Daily average from | | | | | | | Oct. 13, 1903 | 468 | 1027 | 5.69 | 0.392 | 0.904 | |Daily average from | | | | | | | April 13 to June | | | | | | | 27 | | | 5.40 | | | +-----------+-------+-------+------+-----------+-----------+-----------+ | June 28 | 57.5 | 595 | 1026 | 6.75 | | | +-----------+-------+-------+------+-----------+-----------+-----------+

Scrutiny of the tables shows that during this period of nine months the body-weight was practically constant. The daily volume of urine was exceptionally small and fairly regular in amount, the average daily output for the nine months being 468 c.c. It is a noticeable fact that with a diminished intake of proteid food there is far less thirst, and consequently a greatly decreased demand for water or other fluids. Further, in view of the small nitrogenous waste there is no need on the part of the body for any large amount of fluid to flush out the kidneys. The writer has not had a turbid urine during the nine months’ period. With heavier eating of nitrogenous foods, an abundant water supply is a necessity to prevent the kidneys from becoming clogged, thereby explaining the frequent beneficial results of the copious libations of mineral waters, spring waters, etc., frequently called for after, or with, heavy eating. Obviously, a small volume of urine each day means so much less wear and tear of the delicate mechanism of the kidneys. Somewhat noticeable, in a general way, is the apparent relationship between the volume of the urine and the nitrogen output, in harmony with the well-known diuretic action of urea. The specific gravity of the urine shows variation only within narrow limits, the daily average for the nine months being 1027.

Uric acid is noticeably small in quantity, the average daily output for the nine months’ period, based upon the determinations made, being only 0.392 gram.

Chief interest, however, centres around the figures for total nitrogen, since these figures give for each day the extent of the proteid metabolism; _i. e._, the amount of proteid material broken down in the body each day in connection with the wear and tear of the bodily machinery. To fully grasp the significance of these data, it should be remembered that the prevalent dietary standards are based upon the assumption that the average adult must metabolize each day at least 16 grams of nitrogen. Indeed, that is what actual analysis of the urine indicates in most cases. If now we look carefully through the figures shown in the above tables, covering a period from October 13, 1903, to June 28, 1904, it is seen that the daily nitrogen excretion is far different from 16 grams. Indeed, the figures for nitrogen are exceedingly low, and, moreover, they vary little from day to day. The average daily output of nitrogen through the urine for the entire period of nearly nine months is only 5.699 grams.