Part 39

Medicolegal and Social, 454. period of paretic neurosyphilis, 414.

Meilhon, 407.

Memory, failing, 63.

Meningitis hypertrophica cervicalis of Charcot, 56. sympathica, 19. syphilitic, 103.

Mercurialization, 98.

Mercury, 58, 83, 85, 98, 148, 193, 235, 376, 377, 389, 391, 395, 486. untoward results of, 363.

Metasyphilis, 89.

Metchnikoff and Roux, 427, 428.

Microgyria, occipital, 47.

Mignot, Joffroy and, 64, 66.

Migraine, 19.

Mitchell, H. W., 218.

Mœbius, 429.

Mott, F. W., 158, 257, 308, 396, 437.

Multiple sclerosis, 253, 256. relation of syphilis to, 254. spinal fluid findings in, 254.

Muscular atrophy, 149, 446. syphilitic relation to amyotrophic lateral sclerosis, 150.

Muscular weakness, 279.

Myerson, A., 196.

Nageotti, 428.

Nausea, 63.

Neisser, 399.

Nerve trunk tenderness, 148, 234.

Nervousness, 63.

Nervous indigestion, 63.

Neurasthenia, 63, 183.

Neuritis, cranial, 51. optic, 365. root, 235. syphilitic, 235.

Neurorecidive, 152, 153, 184, 196, 235.

Neuroses, relation of syphilis to, 186.

Neurosyphilis, 187, 238, 240, 242. aggravated on military service, 404. atypical, 258, 346. atypical case resembling hysterical fugue, 264. dates, 428. forms of, 20, 21, 28, 29, 95. galloping, 328. history of, 427. incubation period, 152. infectiousness of, 95. laboratory findings in, 82. latent, 142, 203. lesions, 303. lighted up by stress of military service, 412. and marriage, 319. prevention, 320. onset, 64. in primary stage, 186. in secondary stage, 185, 283, 390. in secondary stage, prognosis, 390. in secondary stage, treatment, 153. spinal, 23. and the war, 399, 466.

Nissl-Alzheimer method, 427.

Noguchi, 381. and Moore, 428, 429.

Nonne, 82, 125, 152, 186, 195, 196, 214, 216, 235, 254, 265. -Apelt test, 473.

Numbness, 56.

Nystagmus, 45, 253, 256, 279.

Obersteiner, 249.

Occupation-neurosis, 312.

Ogilvie method, 487.

Operation for gumma, 139.

Optic atrophy, 256. in juvenile paretic neurosyphilis, 154.

Optic thalamus, syphilitic lesion of, 205.

Osteitis, syphilitic, 311.

Ozena, 350.

Pains, 31.

Pandy test, 474.

Paralysis, 123. recovery from, 342. of respiration, 248.

Paranoia, syphilitic, 225.

Paraphasia, 19, 43.

Paraplegia, 26, 30.

Parasyphilis, 89.

_Paresis sine paresi_, 126, 186, 204, 303, 445.

Paresis, see paretic neurosyphilis.

Paretic neurosyphilis, dementia paralytica, general paresis, softening of the brain, 37, 63, 68, 74, 78, 80, 85, 97, 131, 188, 192, 197, 199, 202, 227, 241, 262, 289, 295, 309, 314, 323, 338, 372, 375, 377, 382, 384, 386, 388, 392, 435, 440, 442. adjuvant causes of, 414. causing social complications, 289. causes of death in, 197. course, 85. duration, 88. forms, 95. improvement, 377. incidence among officers, 407. incidence among soldiers, 402. lesions of, 131. “lighted up” by domestic stress in civil life, 420. “lighted up” by “gassing,” 414. mortality from, 89. nomenclature, 88. onset, 192. pathology of, 436. prognosis, 435, 444. symptoms, 90, 131. symptoms, mental, 87. symptoms, physical, 86. versus diffuse neurosyphilis, 165. versus vascular neurosyphilis, 169, 172. with very marked meningitis, 332. with very marked brain atrophy, 335. without mental symptoms, 315. traumatic exacerbation, 310. traumatic form, 308, 413. traumatic, shell-shock, 401. treatment of, 85, 370, 372, 377, 382, 384, 386, 388, 392. treatment, results of, 351.

Pensions for disabilities resulting from venereal disease, 409.

Pensions for neurosyphilis, 411.

Peripheral neurosyphilis, 19.

Perivascular infiltration, 41.

Pernicious anemia with spinal symptoms, 267.

Petit mal attacks, 195.

Pförringer, 61.

Phobia, 67.

Pilcz, Mattauschek and, 347.

Pitres and Marchand, 421, 424.

Plaut, 249, 348, 428.

Plaut, Rehm and Schottmüller, 471.

Plasmocytosis, 40, 49, 55.

Pleocytosis, 23, 220, 247, 344. effect of antisyphilitic treatment on, 244, 376. in remissions, 243. significance of, 243. spinal fluid otherwise negative, 270.

Polydipsia, 190.

Polyuria, 190.

Pontine hemorrhage, 219. softening, 54.

Posey and Spiller, 257.

Potassium iodid, 58, 85, 98, 193, 222, 376, 377, 389, 486.

Preparesis, 65, 77, 78.

Prince, Morton, 195.

Psammoma, 213.

Pseudoneurasthenia, 66.

Pseudoparesis, 449. alcoholic, 222, 229, 451. diabetic, 238. senile, 263. shell-shock, 421. syphilitic, 223, 371.

Pseudoparetic neurosyphilis, 222.

Pseudotabes, shell-shock, 424.

Psychogenic neurosyphilis, 189.

Psychographic disturbance, 228.

Psychopathic personality, 302.

Ptosis, 350.

Pupillary reaction, changes in, 261. signs, 69.

Pupils, Argyll-Robertson, see Argyll-Robertson pupils. irregular, 79, 201. normally reacting in paretic neurosyphilis, 199. sluggish reaction to light, 188. stiff as isolated symptom, 265.

Purkinje cells, binucleate, 48.

Putnam, James J., 19, 56.

Pyramidal tract lesion, bilateral, 326. sclerosis, 44.

Quadriplegia in juvenile paretic neurosyphilis, 275.

Quincke, 427, 428.

_Randsklerose_, 24.

Ravaut, 428.

Ravaut, Sicard, Nageotti, Widal, 428.

Rayneau, 407, 413, 414.

Recovery, 77.

Recurrences, 70.

Redlich, 403.

Régis, 73.

Remissions, 122, 435, 445.

Retardation, 187.

Retention of urine, 56.

Retinitis, hemorrhages, 365.

Richards, R. L., 402, 404, 406, 409.

Robertson, A. R., 59.

Rod cells, 226, 297.

Romberg sign, 141, 216, 279.

Root-sciatica, syphilitic, 418.

Rosenau, 471.

Ross-Jones test, 473.

“Rum fit,” 229.

Ryder, Charles T., 42.

Saddle-shaped nose, 210.

Salivation, 98.

Salmon, Thomas W., 89.

Salvarsan, 75, 83, 85, 193, 222, 377, 389, 486. provocative, 78, 79. untoward results of, 363.

Salvarsanized serum, 75.

Schaudinn, 427, 429.

Sciatic pain in neurosyphilis, 149.

Seizures, 31, 64, 83, 103, 444. causes of in paretic neurosyphilis, 194. Jacksonian, 392. minor, 392.

Senile arteriosclerotic psychosis, 262.

Sensitized cells, 478.

Sérieux and Ducaste, 96.

Shaikewicz, 404.

Shanahan, 278.

Sheep’s corpuscles, 477.

Shock, 42, 81.

Sicard, 428.

Six tests, 80, 85. in tabetic neurosyphilis, 141.

Smith and Solomon, 479.

Social cases, 454. service, 232.

Solomon, 142, 255. and Koefod, 243. Smith and, 479. Southard and, 202, 303.

Somnolence, 45.

Southard, E. E., 48, 134, 212. and Canavan, 70. and Solomon, 202, 303. and Taft, 397.

Spasms, clonic, 326.

Spastic hemiplegia in paretic neurosyphilis, 323.

Spastic paraplegia, Erb’s, 147, 306.

Spasticity, 18, 256.

Speech defect, 69, 133.

Spiller, 150. Posey and, 257.

Spinal fluid findings in secondary stage of syphilis, 151, 185, 283. in juvenile paretic neurosyphilis, 275. negative in diffuse neurosyphilis, 140. negative in gummatous neurosyphilis, 138. negative in neurosyphilis, 216. negative in tabetic neurosyphilis, 269. in tabetic neurosyphilis, 141.

Spinal fluid, withdrawal for therapeutic purposes, 377, 379.

Spinal syphilis, see diffuse neurosyphilis.

Spirochetes, “drug fastness,” 381, 394. strains, 76, 263, 276, 381, 394.

Steida, 405.

Sterility in tabetic neurosyphilis, 144.

Stier, 407.

Stokes, Wile and, 186.

Suicide, 92, 126, 240, 296, 301.

Summary, 427.

Syphilis aggravated by service, 406, 411. on service, 409.

Syphilis as cause of diabetes, 241. as cause of feeblemindedness, 396. hereditaria tarda, 160, 318. history of, 427. lesions in, 329. of lung, 211. from Mongolian, 76. primary, 65. secondary, 65. tertiary, lesions in, 329.

Syphilitic feeblemindedness, pathology of, 160. neuritis, 312. psychosis, 91.

Syphilophobia, 67, 361.

Syphilotoxins, 72.

Swift, 129, 212.

Swift and Ellis, 428, 429. method, 428, 487.

Tabes dorsalis, see tabetic neurosyphilis.

Tabetic neurosyphilis, tabes dorsalis, locomotor ataxia, 30, 31, 141, 146, 366, 367, 434, 446. associated with cerebral symptoms, 177. atypical, 143. cervical, 146. course, 141. with negative spinal fluid findings, 269. prognosis, 94. shell-shock, 403. “shell-shocked” into paretic neurosyphilis, 401. symptoms, 93. symptoms in order of frequency, 145. treatment, 145, 366, 367. plus vascular neurosyphilis, 175. with vascular insult, 30, 439. versus pernicious anemia, 267.

Taboparesis, see Taboparetic neurosyphilis.

Taboparetic neurosyphilis, taboparesis, 92, 135, 195, 284, 443. course, 92. nomenclature, 94. prognosis, 92, 443. and typhoid meningitis, 284.

Taft, A. E., Southard, E. E., and,

Talon, 407.

Taylor, E. W., 50.

Temperature, paretic, 376.

Tests, changes under treatment, 102. changed to negative in paretic neurosyphilis without clinical improvement, 385. changed to less strongly positive in paretic neurosyphilis without clinical improvement, 386.

Therapeutic conception, 324.

Thibierge, 399.

Thierry, 158.

Throbbing in head, 63.

Thrombosis, cerebral, 36, 42, 342, 357, 360, 124.

Thymus, persistent, 282.

Tibial exostoses, 100.

Tigges’ formula, 248.

Todd, J. L., 406, 409.

Transient deafness, 18. blindness, 18. paralysis, 124. paralysis, condition in which occurs, 123.

Trauma and juvenile neurosyphilis, 278, 306. neurosyphilis, 456. paretic neurosyphilis, 199, 308, 310. syphilitic osteitis, 311.

Treatment of neurosyphilis, 67, 75, 83, 124, 148, 184, 222, 235, 299, 328, 332, 335, 342, 346, 350, 351, 355, 384, 390, 392, 395, 419, 439, 457. case in which theoretically of no avail, 323. methods, 356, 486.

Treatment of syphilis, effect on development of neurosyphilis, 142, 347.

Tremor, 197. intention, 256

Tubercle, 80.

Tuberous sclerosis of Bourneville, 47.

Tumor, cerebral, 53, 191, 238, 253. pineal, 213.

Unconsciousness, 53. causes of, 389.

Vascular changes, 220.

Vascular neurosyphilis, 31, 42, 72, 296, 359, 433, 440. plus tabetic neurosyphilis, 175. prognosis, 433. versus paretic neurosyphilis, 169, 172.

Veeder, B. S., 274.

Vertigo, 122.

Viet, 278.

Virchow, 427, 428.

Vomiting, 53, 63.

Warthin, 241.

Wassermann reaction, 191. and alcoholism, 230. in congenital syphilis, 160, 271. meaning of “doubtful,” 360. negative in diffuse neurosyphilis, 184. negative in juvenile paretic neurosyphilis, 298. negative in spinal fluid in spinal syphilis, 148. negative in spinal fluid in neurosyphilis, 101. negative in neurosyphilis, 252. negative in paretic neurosyphilis, 77. technique, 476. titrations in spinal fluid, 348.

Wassermann, Neisser and Bruck, 428.

Weiler, 214.

Weygandt, 403, 404.

Widal, Sicard, Ravaut, 428.

Wiles and Stokes, 186.

Word-deafness, 35, 43.

X-ray diagnosis of bone conditions, 136.

Yerkes-Bridges, 304.

Ziehen, 409.

Zsigmondi, 429, 474.

Footnote 1:

The cases chosen to illustrate the propositions of the boxed headings always illustrate several other points. See the footnotes of Section VI for lists of cases illustrating special points. The names assigned to the cases are fictitious and chosen to suggest race or descent.

Footnote 2:

Notes of Dr. James J. Putnam.

Footnote 3:

M = meningeal V = vascular P = parenchymatous

Footnote 4:

E. E. Southard: Lesions of the granule layer of the human cerebellum; _Journal of Medical Research_, XVI, 1907.

Footnote 5:

Proof of marked parenchymatous lesions must hang on post mortem data; the inference here as to the presence of parenchymatous lesions is a clinical inference.

Footnote 6:

Reprinted from an article by Southard & Solomon: “Latent neurosyphilis and the question of _Paresis sine paresi_.” Boston Medical & Surgical Journal, XXIV, 1.

Footnote 7:

Solomon: “How Shall Latent Syphilis be Treated? The Prophylaxis of Syphilis of the Central Nervous System.” Interstate Medical Journal, XXIII, 8.

Footnote 8:

Joseph Collins: Syphilis of the Brain, _Journal American Medical Association_, July 10, 1915, Vol. LXV, pp. 139–144.

Footnote 9:

A. M. Barrett has recently discussed this subject in a paper in the _Journal of the American Medical Association_, Vol. LXVII, Dec. 2, 1916.

Footnote 10:

Reprinted from an article by Southard & Solomon: “Latent neurosyphilis and the Question of _Paresis sine paresi_.” Boston Medical and Surgical Journal, XXIV, 1.

Footnote 11:

E. E. Southard. A case of glioma of the pineal region, _Am. Jour. of Ins._, Vol. LXI, 1905.

Footnote 12:

Since this was written Collins has had further difficulties related to his neurosyphilis, improving under treatment.

Footnote 13:

Warthin: “Persistence of active lesions and spirochetes in the tissues of clinically inactive or ‘cured’ syphilitics,” _American Journal of Medical Sciences_, CLII, 1916.

Footnote 14:

“The Significance of Changes in Cellular Content of Cerebrospinal Fluid in Neurosyphilis,” _Boston Medical and Surgical Journal_, CLXXIII, 27.

Footnote 15:

Plaut: Ueber Halluzinosen der Syphilitiker, Berlin, 1913.

Footnote 16:

Borden S. Veeder: Hereditary Syphilis in the Light of Recent Clinical Studies; Am. Jour. of Med. Sc., CLII, 1916.

Footnote 17:

Reprinted from article by Southard and Solomon: “Latent Neurosyphilis, the Question of _Paresis sine paresi_,” _Boston Medical and Surgical Journal_, XXIV, 1.

Footnote 18:

(This case was furnished by Dr. D. A. Haller from the Peter Bent Brigham Hospital series.)

Footnote 19:

Fernald, W. E. Standardized Fields of Inquiry for Clinical Studies of Borderline Defectives. Mental Hygiene, Vol. 1, No. 2, April, 1917.

Footnote 20:

Goddard, H. H., Feeblemindedness, its Causes and Consequences, 1914.

Footnote 21:

W. E. Fernald and E. E. Southard. Waverley Research Series in the Pathology of the Feebleminded. Proceedings of the American Academy of Arts and Sciences, 1917.

Footnote 22:

Thibierge. La Syphilis dans l’armée, 1917.

Footnote 23:

Hecht. Wien. klin. Woch., xxix, 51.

Footnote 24:

Donath. Beiträge zu den Kriegsverletzungen und -er-krankungen des Nervensystems. Wiener klin. Wehnschr., No. 27–8, 1915.

Footnote 25:

Duco et Blum. Guide pratique du Médecin dans les Expertises médicolégales militaires. Paris, 1917.

Footnote 26:

Birnbaum. Kriegsneurosen und -psychosen auf Grund der gegenwärtigen Kriegsbeobachtungen: Sammelbericht. Z. f. d. ges. Neurol. u. Psychiat., Bd. XII, H. 1, 1915.

Footnote 27:

Weygandt. Kriegseinflüsse und Psychiatrie. Jahreskurse f. ärztl. Fortbildung, Maiheft, 1915.

Footnote 28:

Bonhoeffer. Erfahrungen über Epilepsie und Verwandtes im Feldzuge. Monatschr. f. Psychiat u. Neurol., Bd. 38, H. 1–2, 1915.

Footnote 29:

Exner, M. J., Prostitution in its relation to the army on the Mexican Border, _Social Hygiene_, Vol. 3, 2, April, 1917.

Footnote 30:

Bonhoeffer, _loc. cit._

Footnote 31:

We have recently reviewed the outcome in 300 _untreated_ cases of paretic neurosyphilis (Psychopathic Hospital material, strictly comparable with treated cases) finding but 5 now capable of self-support and 10 more in normal-looking remission. This percentage is far lower than that in treated cases (at present, July, 1917, 50 in 200 capable of self-support).

Footnote 32:

Alice Morton (1).

Footnote 33:

Francis Garfield (2).

Footnote 34:

John Dixon (3).

Footnote 35:

James Pierce (4).

Footnote 36:

John Lawrence (5).

Footnote 37:

Flora Black (6).

Footnote 38:

Mrs. Lecompte (7).

Footnote 39:

John Wyman (8).

Footnote 40:

Greeley Harrison (9). _Also_ Albert Robinson (45), Alice Caperson (46), Abel Bachmann (74).

Footnote 41:

Lyman Agnew (10). _Also_ Ethel Hunter (47), Bessie Vogel (52), Isaac Thompson (83), Juliette Lachine (11).

Footnote 42:

Juliette Lachine (11). _Also_ Lyman Agnew (10), Ethel Hunter (47), Bessie Vogel (52), Isaac Thompson (83).

Footnote 43:

Henry Philipps (12). _Also_ Bridget Curley (59), Margaret O’Brien (68), Annie Martin (117).

Footnote 44:

William Twist (13). _Also_ Lester Crane (20), Thomas Donovan (23).

Footnote 45:

John Jackson (14). _Also_ Martha Bartlett (21), Paolo Marini (28), Margaret O’Brien (68).

Footnote 46:

Pietro Martiro (15). _Also_ Meyer Levenson (22), Achilles Akropovlos (50).

Footnote 47:

Joseph Sullivan (16).

Footnote 48:

Gregorian Petrofski (17). _Also_ Richard Lawlor (25), John Bennett (34), Julius Kantor (54), Albert Forest (112).

Footnote 49:

Frederick Wescott (18). _Also_ Martha Bartlett (21), James Burns (56), Victor Friedburg (108).

Footnote 50:

Agnes O’Neil (19). _Also_ Michael O’Donnell (24). John Edwards (104). Arthur Bright (121).

Footnote 51:

Lester Crane (20). _Also_ Greeley Harrison (9). David Borofski (49). David Collins (61).

Footnote 52:

Martha Bartlett (21). _Also_ Agnes O’Neil (19), Vivian Walker (87).

Footnote 53:

Meyer Levenson (22). _Also_ Albert Forest (112).

Footnote 54:

Thomas Donovan (23). _Also_ William Twist (13), Bessie Vogel (52), David Collins (61).

Footnote 55:

Michael O’Donnell (24). _Also_ Alice Morton (1).

Footnote 56:

Richard Lawlor (25). _Also_ Bessie Vogel (52), —— —— (88).

Footnote 57:

John Morrill (26).

Footnote 58:

David Tannenbaum (27). _Also_ Mrs. LeCompte (7), Annie Rivers (109).

Footnote 59:

Paolo Marini (28). _Also_ Flora Black (6).

Footnote 60:

Mario Sanzi (29). _Also_ Stephen Green (30), Paul Halleck (31).

Footnote 61:

Stephen Green (30). _Also_ Paul Halleck (31), Henri Lepère (105), Ivan Rokicki (111).

Footnote 62:

Paul Halleck (31).

Footnote 63:

Margaret Neal (32).

Footnote 64:

Joseph Graham (33).

Footnote 65:

John Bennett (34). _Also_ Alice Caperson (46), Florence Fitzgerald (81), Vivian Walker (87), Arthur Bright (121).

Footnote 66:

Mary Coughlin (35).

Footnote 67:

Theresa Mullen (36). _Also_ John Lawrence (5), John Friedreich (77), Gridley Ringer (78), James Arnold (80).

Footnote 68:

Isaac Goldstein (37).

Footnote 69:

Archibald Sherry (38).

Footnote 70:

Caroline Davis (39). H. F. (40). Samuel North (41). Elizabeth Brown (42). Robert Allen (43). John Hughes (44).

Footnote 71:

Albert Robinson (45). _Also_ Greeley Harrison (9).

Footnote 72:

Alice Caperson (46). _Also_ Florence Fitzgerald (81).

Footnote 73:

Ethel Hunter (47). _Also_ Lyman Agnew (10), Bessie Vogel (52), Juliette Lachine (11).

Footnote 74:

Milton Safsky (48). _Also_ Daniel Falvey (55).

Footnote 75:

David Borofski (49). _Also_ Lester Crane (20).

Footnote 76:

Achilles Akropovlos (50).

Footnote 77:

Daniel Wheelwright (51).

Footnote 78:

Bessie Vogel (52). _Also_ Lyman Agnew (10), Juliette Lachine (11), Ethel Hunter (47).

Footnote 79:

Carrie Pearson (53).

Footnote 80:

Julius Kantor (54). _Cf._ James Burns (56). Henri Lepère (105). Frederick Stone (106).

Footnote 81:

Daniel Falvey (55). _Cf._ Francis Murphy (60).

Footnote 82:

James Burns (56). _Also_ Frederick Wescott (18), Martha Bartlett (21), Victor Friedburg (108).

Footnote 83:

John Summers (57).

Footnote 84:

Peter Burkhardt (58).

Footnote 85:

Bridget Curley (59).

Footnote 86:

Francis Murphy (60).

Footnote 87:

David Collins (61).

Footnote 88:

Joseph Buck (62).

Footnote 89:

Albert Fielding (63).

Footnote 90:

Calvin Hall (64).

Footnote 91:

Donald Barrie (65).

Footnote 92:

Lawrence Washington (66).

Footnote 93:

Joseph Temple (67).

Footnote 94:

Margaret O’Brien (68). _Also_ Henry Phillips (12). Bridget Curley (59). Annie Martin (117).

Footnote 95:

Frank Mason (69).

Footnote 96:

Annie Kelly (70). James Lauder (71).

Footnote 97:

James Lauder (71).

Footnote 98:

Margaret Green (72).

Footnote 99:

Marcus Chatterton (73).

Footnote 100:

Abel Bachmann (74).

Footnote 101:

Mrs. Brown (75).

Footnote 102:

James Seabrook (76).

Footnote 103:

John Friedreich (77). _Cf._ Isaac Goldstein (37).

Footnote 104:

Gridley Ringer (78).

Footnote 105:

John Doran (79).

Footnote 106:

James Arnold (80).

Footnote 107:

Florence Fitzgerald (81). _Also_ John Bennett (34), Alice Caperson (46), Vivian Walker (87), Arthur Bright (121).

Footnote 108:

Frederick Estabrook (82).

Footnote 109:

Maj. Isaac Thompson, M.D. (83).

Footnote 110:

Lester Smith (84).

Footnote 111:

Annie Marks (85).

Footnote 112:

Frank Johnson (86).

Footnote 113:

Vivian Walker (87).

Footnote 114:

—— —— (88). _Cf._ Richard Lawlor (25). Bessie Vogel (52).

Footnote 115:

Margaret Tennyson (89). John Lawrence (5). Mary Coughlin (35). Theresa Mullen (36). John Friedreich (77). Gridley Ringer (78). James Arnold (80).

Footnote 116:

Joseph O’Hearn (90).

Footnote 117:

Levi Sussman (91).

Footnote 118:

Joseph Larkin (92).

Footnote 119:

Richard Marshall (93).

Footnote 120:

David Fitzpatrick (94).

Footnote 121:

Joseph Wilson (95).

Footnote 122:

Becky Bornstein (96). Walter Heinmas (97). Mr. Jacobs (98).

Footnote 123:

Walter Heinmas (97).

Footnote 124:

Mr. Jacobs (98).

Footnote 125:

James McDevitt (99).

Footnote 126:

Jacob Methuen (100).

Footnote 127:

John Baxter (101).

Footnote 128:

Theodosia Jewett (102).

Footnote 129:

A. W. (103).

Footnote 130:

John Edwards (104). _Cf._ Henri Lepère (105), Frederick Stone (106), Arthur Bright (121), Agnes O’Neil (19), Paolo Marini (28).

Footnote 131:

Henri Lepère (105). _Cf._ Julius Kantor (54).

Footnote 132:

Frederick Stone (106).

Footnote 133:

Greta Meyer (107). _Cf._ John Jackson (14).

Footnote 134:

Victor Friedburg (108).

Footnote 135:

Annie Rivers (109).

Footnote 136:

Mr. McKenzie (110). _Cf._ Ivan Rokicki (111).

Footnote 137:

Ivan Rokicki (111).

Footnote 138:

Albert Forest (112). _Cf._ Gussie Silverman (113), Walter Henry (114), William Rosetti (116), Annie Martin (117), Levi Morovitz (122), Peter Burkhardt (58).

Footnote 139:

Gussie Silverman (113).

Footnote 140:

Walter Henry (114).

Footnote 141:

Henry Ryan (115).

Footnote 142:

William Rosetti (116).

Footnote 143:

Annie Martin (117). _Cf._ William Roberts (118).

Footnote 144:

William Roberts (118). John Silver (119).

Footnote 145:

John Silver (119).

Footnote 146:

James McGinnis (120).

Footnote 147:

Arthur Bright (121). _Cf._ Levi Morovitz (122), John Bennett (34).

Footnote 148:

Levi Morovitz (122).

Footnote 149:

Robert Matthews (23). _Cf._ Isaac Goldstein (37).

Footnote 150:

For cases in which, without autopsy we have risked the diagnosis neurosyphilis _in the absence of W. R. in serum or fluid_, see William Twist (13), Frederick Wescott (18), Martha Bartlett (21), Thomas Donovan (23), Paolo Marini (28), Margaret Neal (32), Bridget Curley (59), Victor Friedburg (108), Ivan Rokicki (111).

Footnote 151:

From Mallory and Wright: Manual of Laboratory Technique.

Footnote 152:

Bruck. Münch. med. Wochen. Jan. 22, 1917.

Footnote 153:

Smith and Solomon. Boston Medical and Surgical Jour.

Footnote 154:

Bruck: Journal of American Medical Association, Vol. lviii, No. 12, March 24, 1917, p. 944.

TRANSCRIBER’S NOTES

1. Pg. 456, added footnote anchor for footnote A. 2. Silently corrected typographical errors and variations in spelling. 3. Archaic, non-standard, and uncertain spellings retained as printed. 4. Footnotes were re-indexed using numbers and collected together at the end of the last chapter. 5. Enclosed italics font in _underscores_. 6. Enclosed bold font in =equals=. 7. Subscripts are denoted by an underscore before a series of subscripted characters enclosed in curly braces, e.g. H_{2}O.