Category: Science - Biology
Sir: I have the honor to submit for your approval a manuscript on the toxicity of caffein, which is the first of a series of reports to be made by Dr. Salant on the pharmacology of this drug; the conclusions here reported are, therefore, in some particulars to be regarded as t...
June 21: Weight 7.5 kilos, 1.5 grams caffein given at 10 a. m. At 2 p. m. convulsions and death. This dog received a total of 21.15 grams caffein in 25 doses during a period of...
7. Part 7The results of the experiments on rabbits show considerable variation in the toxicity of the single dose. Individuals differed so widely in their resistance to this drug that th...
2. Part 2These observations seemed to be confirmed by Pratt(74) (1868), who reported that the isolated posterior extremities and muscle fibers of the toad placed in a solution of caffein...
3. Part 3March 18: 9 cc 2 per cent caffein (205 mg per kilo) injected subcutaneously at 3 p. m.; 3.30 p. m., rabbit became restless, reflexes were increased, tremors were observed, but n...
12. Part 12September 9: Found dead 9 a. m. _Autopsy_: Both lungs showed extensive pneumonia, with adhesions to pleura; pleuritis and pericarditis very marked; large amount of fibrous exuda...
9. Part 9Rost stated that caffein is eliminated in the urine unchanged after its introduction into the body and that the amounts found varied with different species of animals. In the ra...
15. Part 15+--------+----------+-----------+---------------------------- | | |Treatment | Date. | Weight.| Food. |(2 per cent| Symptoms. | | | caffein). | ---------+--------+----------+---...
4. Part 4----+--------+-------+-------------+--------------+-------+----------- 247| 1,295 | 200 |2.5 hours |Survived |Oats |Gray. 248| 1,305 | 200 |3 hours | do. | do. | Do. 337| 1,040...
1. Part 1Sir: I have the honor to submit for your approval a manuscript on the toxicity of caffein, which is the first of a series of reports to be made by Dr. Salant on the pharmacology...
5. Part 5January 25: 3 p. m., 7 cc 2 per cent caffein (0.2 gram per kilo) solution injected into peritoneal cavity; 3.15 p. m., reflexes increased and anterior extremities paralyzed.
6. Part 6Examination of Table 4 shows that 14 rabbits received from 180 to 210 mg caffein per kilo. The appearance of symptoms in these rabbits varied considerably. In some increased ref...
8. Part 8October 3: 2 p. m., 3.75 cc (0.2 gram per kilo) injected into peritoneal cavity; 2.15 p. m., reflexes increased but not markedly; 4 p. m., reflexes still more increased; no othe...
10. Part 10+--------+---------+-----------------------+------------------- Number.|Weight. | Caffein | Symptoms. | Duration of life. | |per kilo.| | -------+--------+---------+------------...
14. Part 14December 23: 11.30 a. m., received 1.375 grams caffein (0.125 gram per kilo) had vomited food of the day before, but could notice no caffein or capsules in vomit; 4.30 p. m., no...
11. Part 11The question whether caffein is cumulative in the rabbit, suggested in the preceding experiments, was the subject of further investigation in Series B. Caffein was given by mout...
16. Part 16The data for Rabbit 123 is presented as printed in the original, although it is likely that the Caffein per kilo. values should be preceded by a decimal point (or that the headi...