Chapter 12

Uses.--This plant seems to possess anthelmintic properties and for this purpose it is administered in powder, 2-4 grams with a little molasses or syrup. It is bitter and aromatic and is given in diseases of the stomach and intestines for its tonic and stimulant effect. The odor of the drug is transmitted to both urine and sweat. In India it is used in "bilious diseases" and to dissipate all sorts of tumors. The Hindoos cook it with flour, lard and sugar and eat the mixture as a tonic and to prevent gray hair and baldness. They also give the seed, fried in oil, as an aphrodisiac. The aqueous distillate is a good preparation as it contains the active principle of the plant, a yellow, viscid, essential oil.

Botanical Description.--A plant about 1° high, stem and branches bearing 3 serrate wings. Leaves premorse, lanceolate, decurrent, downy. Flowers white, in a globose head, divided into 50 or more groups each with its own calyx of 9 or 10 leaflets surrounding 2 or 3 hermaphrodite, 5-toothed, campanulate flowers. Anthers 5, united. Style 1, thick at extremity. Stigma none. Corolla of pistillate flowers very minute, with 3 obscure teeth. Stigma of 2 down-curved divisions. One seed, 4-angled, imbricated.

Habitat.--The rice fields. Blooms in January.

_Spilanthes Acmella_, L.

Nom. Vulg.--_Hagonog_, Tag.; _Agonoy_, Sp.-Fil., Vis.(?); _Palunay_, Pam.

Uses.--Some native herb-doctors use the root as a purgative, giving a decoction of 4-8 grams to a cup of water. The infusion is used locally for itch and psoriasis. Internally it has a diuretic effect and is reputed to be a solvent of vesical calculi. The leaf juice and the bruised leaves are applied to wounds and atonic ulcers. These leaves with those of "sambon" and "sampaloc" (tamarind) are used to prepare aromatic baths for convalescents, rheumatics and pregnant women.

Botanical Description.--A plant with stem drooping, square, grooved, covered with drops of gum resin. Leaves opposite, cordate, oval, lanceolate, serrate, 3 prominent nerves covered with short down. Petioles short, grooved. Flowers yellow, in a sort of umbel, with 3 or more flowerets on long peduncles. Common calyx, 9-11 narrow sepals, concave, fleshy, in 2 rows. Hermaphrodite disk-flowers 40 or more. Corolla tubular, 5-toothed. Anthers longer than corolla. Pistil longer than stamens. Style bifid. Pistillate flowers, 15 or more, forming the rays. Corolla monopetalous, 3-toothed. Style and stigma as in hermaphrodite flowers. Seeds of hermaphrodite flowers quadrangular, crowned by one long awn, and the rudiment of another. Seeds of ray flowers small and sometimes flattened, 2 awns, of which one alone lengthens and becomes conspicuous. Receptacle covered with concave scales.

Habitat.--Grows along the shores of the sea and of rivers. It is very well known.

_Artemisia vulgaris_, L. (_A. Indica_, Willd.)

Nom. Vulg.--_Ka-María_, _Santa María_, _Tinisas_, Tag.; _Indian Wormwood_, Indo-Eng.

Uses.--The native women use the infusion of its aromatic leaves to induce menstruation. It is also used as an abortifacient, but is too mild a uterine stimulant to be reliable for that purpose. Its stomachic and tonic properties are common knowledge in the Philippines. The Hindoos use it for those effects and as an antispasmodic in amenorrhoea and hysteria. Dr. Wight states that the leaves and tops are useful in nervous troubles resulting from debility and that a decoction of them makes a good fomentation for phagedenic ulcers.

The infusion is prepared in the proportion of 10-30 grams of leaves to 1 liter of water and the powdered leaves are given in doses of 4-8 grams; the aqueous extract 30-40 grams a day. For amenorrhoea the drug is given daily for a week preceding the menstrual date.

Botanical Description.--A plant 3° high, stem straight, woody, square toward ends of branches. Leaves alternate, tomentose, decurrent, divided in several places, medium lanceolate. Flowers straw-colored, in axillary and terminal, 1-ranked spikes. Common calyx cylindrical, 2 circles of oval, scarious leaflets around its border, 11 hermaphrodite disk-flowers and about 5 pistillate ray-flowers. Hermaphrodite: Corolla bell-shaped, 5 obtuse teeth; stigmas 2, bent to the sides. Pistillate: Corolla diminutive, 5 toothlets; anther none; stigmas 2. Seeds of both small and quadrate, smaller in the latter. Receptacle nude.

Habitat.--Grows throughout the islands and is well known.

_Carthamus tinctorius_, L.

Nom. Vulg.--_Azafrán de la tierra_, Sp.; _Biri_, _Kasubha_, _Katsumba_, _Lago_, Tag.; _Kasabba_, Vis.; _Kasubha_, _Kastumba_, Pam.; _Bastard Saffron_, _Dyer's Safflower_, Eng.

Uses.--This plant must not be confounded with _Curcuma longa_, L., whose tuber is also frequently called saffron (azafrán), and is used to color food.

The flower is the part employed as a condiment coloring the food yellow. Some use them internally in doses of 4 grams to cure icterus. The leaves coagulate milk. The seeds are purgative in dose of 8-16 grams, bruised and taken in emulsion, or 15-30 grams in decoction.

The following is the chemical analysis of the plant:

Yellow coloring matter, soluble 26.1-36.0 Carthamic acid 0.3- 0.6 Extractive matter 3.6- 6.5 Albumin 1.5- 8.0 Wax 0.6- 1.5 Cellulose, pectin 38.4-56.0 Silica 1.0- 8.4 Oxide of iron, aluminum, oxide of manganese 0.4- 4.6

(Salvetat.)

Botanical Description.--A plant 3° high, root gray and spindle-shaped. Stem straight, few branches. Leaves scattered, sessile, partially embracing the stem, lanceolate, serrate with hooked teeth. Flowers yellow, terminal in a sort of corymb. Common calyx semiglobose, with imbricated scales, the border often bearing thorns; numerous hermaphrodite disk flowers, with corolla very long, funnel-form, 5-toothed. Style longer than the stamens. Stigma bifid. Seed large, lacking pappus.

Habitat.--Cultivated in the gardens.

PLUMBAGINEÆ.

Leadwort Family.

_Plumbago Zeylanica_, L. (_P. viscosa_, Blanco.)

Nom. Vulg.--_Sagdikit_, Tag.; _Bagbag_, _Talankaw_, Iloc.; _White-flowered Leadwort_, Eng.

Uses.--The root is vesicant and is used by the natives for this purpose. (_P. rosea_, L., common in India, is more powerful. The Pharmacopoeia of India states that both species are worthy of further investigation.) According to the Sanscrit authors it increases the appetite and is useful in dyspepsia, piles, dropsy, diarrhoea and skin diseases. The Filipinos use the infusion locally for itch with good results. A favorite medicine of the Hindoos for flatulence is the old recipe of Susrutas, composed of equal parts of the following substances in powder:

Leadwort root, root of _Cissampelos Pareira_, _Picrorrhiza kurroa_, [6] _Aconitum heterophyllum_,1 and _Terminalia Chebula_ in dose of 4 grams a day.

Dr. Oswald has employed the alcoholic tincture of leadwort in the intermittents, with satisfactory results, and claims that it is a powerful diaphoretic. [7] The mashed root is mixed with rice flour and made into a caustic paste to apply to buboes, destroy warts, etc. Women also use the scraped root to induce abortion, introducing it through the vagina into the _os uteri_. This practice should be strongly condemned on account of its dangerous consequences--metritis, peritonitis and often death.

The chemical composition of the root has been studied by Dulong. [8] It includes a non-nitrogenous principle, plumbagin, existing in the form of orange-yellow needles, bitter, acrid, volatile, neutral, slightly soluble in cold water, more soluble in ether, alcohol and hot water. The aqueous solution becomes cherry-red on the addition of an alkali, which color is changed to yellow by acids. Basic acetate of lead causes the same color change.

Botanical Description.--Plant with stem declined, angular. Leaves lanceolate, entire, rather downy. Petioles at their base embrace the stem. Flowers white, in axillary spikes. Individual involucres, 3 oval leaflets, the lower larger. Calyx long, cleft almost to the base in 5 lineal parts thickly set with small glands, exuding a sticky gum. Corolla salver-shaped, the tube long, square, throat bare, limb divided into 5 obovate parts, ending in stylets. Stamens 5, inserted near the base of the corolla, almost as long as the tube. Style a little shorter than the stamens. Stigma, 5 parts. One long seed enclosed within the calyx, pentangular, covered with a membranaceous skin.

Habitat.--In Tanauan (Batangas).

SAPOTACEÆ.

Sapodilla Family.

_Achras Sapota_, L.

Nom. Vulg.--_Chico_, Sp.-Fil.; _Tsiku_, Tag.

Uses.--The _chico_ is one of the popular fruits of the Philippines, much appreciated by Europeans as well as the natives. When not entirely ripe it yields a resinous juice that sticks to the lips and affords a disagreeable taste; but when once thoroughly ripe it has a slightly vinous, sweetish taste and is easily digested. Therapeutically its seeds are used as a diuretic, but large doses should be avoided as they contain a small proportion of hydrocyanic acid. The proper dose is 5-6 mashed seeds in sweetened water. They contain, in addition to the above, a fatty substance of the consistency of butter.

The trunk bark is tonic and febrifuge; Mr. Bernon [9] has isolated from it a crystalline alkaloid, _sapotine_, soluble in ether, chloroform or alcohol, but not in water; a large per cent. of _sapotanic acid_ and two resins.

The trunk exudes, when incised, a milky resin, closely resembling guttapercha and possibly susceptible of the same uses.

Botanical Description.--Trees, about 11° high, with leaves lanceolate, keeled, entire, glabrous. Flowers pure white, solitary or by twos, terminal, very long peduncles. Calyx, 6 sepals, 3 within the others, inferior persistent. Corolla jug-shaped, the border divided into 12 parts, the 6 smaller ones alternating and within the others. Stamens 6, inserted near the border of the inner petals and opposite the outer circle. Filaments very short. Style long. Stigma obtuse, fruit globose, resembling a small pear, russet brown, crowned with the hardened style, more than 10 compartments, each containing a seed. Seed oval, flattened, joined to a central fleshy axis.

Habitat.--Common all over the Archipelago. Blooms in April.

_Mimusops Elengi_, L.

Nom. Vulg.--_Kabiki_, Tag.

Uses.--Its flowers are fragrant and generally well known. The trunk bark is astringent, and in decoction is given by mouth for fevers and diarrhoea. Locally is used as an injection for blenorrhoea, as a gargle for sore throat or relaxed uvula, and a mouth wash to harden the gums. Horsfield states that the Javanese use it as a tonic and antiperiodic. In India an aqueous distillate is employed as a perfume and therapeutically as a stimulant. In Concan they chew the green fruit for toothache and to harden relaxed gums. The decoction of the green fruit serves the same purpose and besides is used to wash wounds and ulcers.

Botanical Description.--A large ornamental tree with leaves alternate, oblong, coriaceous, green. Flowers small, straw-colored, star-shaped, very fragrant. Calyx, 8 sepals. Corolla gamopetalous, 16 oblong, lanceolate divisions. Stamens 8, free, short, alternating with 8 petaloid, conical, pubescent staminodia. Ovary free, many ovules. Fruit fleshy, oval, smooth, yellow when ripe, with one or several locules according to the number of matured seeds. Seeds solitary, oblong, flattened.

Habitat.--Cultivated in the gardens.

OLEACEÆ.

Olive Family.

_Jasminum Sambac_, Aiton. (_Nyctanthes Sambac_, Blanco.)

Nom. Vulg.--_Sampaga_, Tag.; _Sampaguitas_, Sp.-Fil.; _Arabian Jasmin_, Eng.

Uses.--The flower is the most popular and beloved of any in the Philippines (and is commonly referred to as the national flower). In decoction it is used as an eye-wash in catarrhal conjunctivitis. In India the flowers and the leaves have a merited reputation as a lactifuge; 2 handfuls of flowers bruised and applied without moistening, once or twice a day, sometimes checks the secretion of the milk within 24 hours, but generally 2 or 3 days are required for a complete effect.

Botanical Description.--Stems scarcely climbing, flattened, pubescent. Leaves opposite, cordate base, lanceolate-ovate, entire, glabrous. Flowers in small, close clusters, white, fragrant. Calyx-teeth 8-9, long and awl-shaped. Corolla, long tube, 7-8 rounded lobes. Stamens 2. Style 1. Stigma cleft in 2 laminæ.

APOCYNACEÆ.

Dogbane Family.

_Allamanda cathartica_, L.

Nom. Vulg.--Not known.

Uses.--As this plant has no common name in the Philippines it is most probable that the natives do not use it. The Portuguese introduced it into India from Brazil. A decoction of the leaves is purgative and is used in lead colic. The milky juice of the plant is emetic and cathartic in large doses, but simply laxative when given in doses of 8 or 10 drops. On account of its possible violent cathartic action great prudence should be exercised in prescribing it.

Botanical Description.--A twining shrub with leaves in fours, bright green, oblong, covered with rough hairs. Flowers in compound spikes, yellow. Calyx 5-toothed. Corolla 5-lobed, funnel-form. Stamens 5, inserted in throat of corolla, which above them is closed by a crown of hairs. Ovary 1-celled with 2 many-ovuled placentæ. Style cylindrical, terminating in a bilobulate cone. Capsule globular, about the size of a pea, black, coriaceous, thorny, bivalvate. Seeds numerous, each encircled by a broad membranous wing.

Habitat.--In Calauang and other parts of Luzon and Panay.

_Thevetia nerifolia_, Suss. (_Cerbera Thevetia_, L. and Blanco)

Nom. Vulg.--_Campanelo_, Sp.-Fil.; _Exile or Yellow Oleander_, Eng.

Uses.--This shrub is very common in gardens, well known by its pretty yellow, bell-shaped flowers. The trunk bark possesses antiperiodic properties first described by Descourtilz and confirmed later by Dr. G. Bidie and Dr. J. Short. Both the latter used the tincture in 10-15-drop doses 3 times a day. This tincture was prepared by macerating for one week in 150 grams of alcohol 30 grams of fresh bark finely divided. This preparation operates as an emetic and purgative in doses of 30-60 drops. It is evident that the plant possesses very active, even poisonous properties and should be employed with great caution. The decoction of the bark is given as an emetic and cathartic, but very imprudently because there is no means of determining the quantity of active principle, shown by chemical analysis to be a dangerous product.

The fruit is very bitter and acrid. The seeds yield by expression 35 to 41% oil (De Vry) and 57% when treated with benzol. It has an agreeable odor resembling that of sweet almonds, its density is 0.9148 at 25° and it is perfectly clear and transparent at that temperature. At 15° it thickens and at 13° solidifies. According to Oudemans it consists of 63% triolein and 37% tripalmin and tristearin; it is not poisonous. After expression De Vry obtained from the caked residue 4% of a crystalline glucoside called by him _thevetin_. Blas, of the Academy of Medicine of Belgium, studied it later and described it as a white powder of small colorless scales, odorless, very bitter, soluble at 14° in 122 parts of water, in alcohol, in crystallizable acetic acid, insoluble in ether; formula C_54_H_34_O_24_. Concentrated sulphuric acid dissolves it, producing a dark red color that changes to cherry red and then after several hours to violet. The color disappears if water be added. Boiled in acid solution the glucoside changes to a new substance, _theveresin_ (C_48_H_70_O_17_), white, amorphous, slightly soluble in boiling water and in alcohol, insoluble in benzine or chloroform, soluble in alkalies, very bitter. Both substances are energetic narcotic poisons; but the plant contains another even more powerful poison isolated by Warden, of Calcutta; it does not form crystals, it is very bitter, freely soluble in water, and is turned yellow by sulphuric and nitric acids.

Thevetin and theveresin exercise a marked toxic effect on the heart. The former induces emetic and cathartic phenomena, trembling and progressive weakness. The latter does not cause vomiting or diarrhoea, but anæsthesia and rigidity of the limbs. Both poisons arrest the heart in systole. Injected hypodermically they are irritant, are eliminated by the liver, but are not found in the urine.

Botanical Description.--A shrub, about 10° high, with leaves nearly sessile, somewhat bunched at the ends of the branches and overlapping, lanceolate, entire, glabrous. Flowers about 2' long. Calyx 5-toothed. Corolla straw-colored, cylindrical, very narrow below, but the limb very large, spreading into 5 lobes with greenish, superimposed borders. Stamens 5, inserted in the throat, anthers lanceolate. Ovaries 2, united at base, free above, unilocular. Style simple, enlarging at the base in a bilobed stigma. Fruit a fleshy drupe resembling somewhat a small apple, the pit very hard, semilunar, flattened, with 4 compartments and as many solitary seeds.

Habitat.--Common in all gardens and on the seashore.

_Cerbera Odallam_, Gaertn. (_C. manghas_, Bl. & Blanco.)

Nom. Vulg.--_Toktok-kaló_, Tag.

Uses.--The milky juice of the plant is emetic and purgative. The chemist De Vry has isolated from it a poisonous alkaloid analogous to "thevetin," which has just been considered. The seeds are likewise emetic and toxic. The Javanese call the fruit "bimaro" and affirm that it possesses the same properties as "datura." The bruised leaves are used locally for hepatic eruptions; the bark is used for the same purpose and is purgative.

The use of the plant is dangerous and is condemned by the Pharmacopoeia of India.

Botanical Description.--A small shrub with forked branches. Leaves (overlapping) at ends of branches, lanceolate, entire, glabrous. Flowers in umbellate spikes. Calyx, 5 caducous lobules. Corolla white, twisted, cylindrical, with salver-shaped limb divided in 5 rhomboid lobes, throat stellate and woolly. Stamens 5. Filaments joined to the corolla, their ends thickened. Anthers arrow-shaped. Ovary, 2 uniovulate locules. Style, same length as stamens. Stigma thick, conical, lobulate. Two drupes joined at the base (one usually aborted), brown, large, oval, fleshy, with woody fibrous nut of a single flattened seed.

Habitat.--Luzon. Blooms in July.

_Plumeria acutifolia_, Poir. (_P. alba_, Blanco.)

Nom. Vulg.--_Calachuche_, Sp.-Fil.; _Kalatsutsi_, _Kalasusi_, Tag.

Uses.--This tree, beloved for its fragrant flowers, has a wide therapeutic use in India and the Philippines. The bark is a bitter hydragogue cathartic and is given in decoction (5-10 grams to 200 water) principally for dropsy; however the milky juice of the trunk is preferable for this purpose, given in emulsion in doses of 0.50-0.80 grams. The bark and the tips of the branches are given as an emmenagogue.

The bark of the root and of the trunk is an excellent remedy for blenorrhagia. The fresh bark is thoroughly comminuted and mixed with sweetened water in the proportion of 60 grams to 4 liters; this mixture is put in the sun for 4 days, and shaken from time to time. It is then strained and given in doses of 4-5 glassfuls a day, at the same time with refreshing and emollient drinks, and prolonged tepid baths. At first this preparation exerts a purgative action, but later acts upon the urinary organs, rapidly lessening the suppurative process in urethritis. The bark may also be associated with wine or beer, in the proportion of 30 grains to the liter, the dose being 2-4 small cupfuls a day and Dr. Grosourdy employs the extract of the bark in doses aggregating 0.20-0.25 gram a day, gradually increased till at the end of a week 6 grams are taken daily (Dr. J. Amadeo).

The bruised leaves are applied locally to contusions to reduce the swelling. The juice is used externally as a rubefacient in rheumatic affections of the joints. In Concan they use a decoction of the root for diarrhoea. The flower buds are chewed with _buyo_, for intermittent fever and the juice is applied locally for itch.

Peckolt and Geuther isolated from the bark the glucoside, _agoniadin_ (C_10_H_14_O_6_), which crystallizes in silky crystals fusible at 155°, slightly soluble in water, alcohol, bisulphuret of carbon, ether and benzine; soluble in nitric or sulphuric acids. In solution it is a golden yellow soon changing to green. Boiled in a dilute acid it splits into glucose and an undetermined substance. Oudeman obtained _plumieric_ acid (C_10_H_10_O_5_) from the milky juice deprived of its resin; the acid exists as microscopic, needle-like crystals, soluble in boiling water, alcohol and ether. It melts and decomposes at 130°.

Botanical Description.--A tree, 12-18° high, commonly cultivated for ornament, well known in the islands, almost constantly bearing fragrant flowers, but rarely bearing fruit. Branches forked and peculiarly stumpy at the ends. Leaves alternate, broad lanceolate, entire, glabrous, the apices curved downward. Petioles short. Flowers creamy white, light yellow in the throat. Calyx 5-toothed. Corolla twisted, funnel-form, 5-lobed. Stamens 5, hidden in depths of the tube. Anthers dart- or arrow-formed. Style very short, thickened above. Stigma 2-parted. Two horizontal, cylindrical and long follicles joined at their bases, with numerous seeds in hollow receptacles, each seed encircled by a wing.

_Alstonia scholaris_, Br. (_Echites scholaris_, L. and Blanco.)

Nom. Vulg.--_Dita_, Tag.; _Dallopawen_, Iloc.; _Dita_ or _Alstonia Tree_, Eng.

Uses.--The trunk bark is a febrifuge of great importance; it is official in the Pharmacopoeia of India and is widely used in the Philippines. Personally I have had occasion to use it in several cases of malarial fever in the town of San Mateo near Manila. It is astringent, anthelmintic and antiperiodic, highly useful in chronic diarrhoea and dysentery, not only for its astringent effects but for its tonic and restorative action. As a tonic it gives as good results as quinine. The dry powdered bark is given internally in wafers of 20-30 centigrams. The infusion is prepared from 15 grams of the dry comminuted bark to 300 of water. The dose is 30-60 grams 2 or 3 times a day.

Another convenient preparation is the tincture, 75 grams of the powdered bark macerated 7 days in 500 grams of alcohol, shaking from time to time. It is then filtered and enough alcohol added to make up the 500 cc. The dose is 4-8 grams a day.

I have often used the following wine as a tonic for convalescents and patients suffering from general debility: Finely powdered bark, 25 grams, muscatel or dry sherry one bottle; macerate a week, shaking every day, and filter; dose 1/2 wineglass with equal parts water a few minutes before each meal; children or very weak patients should take it after eating; it should always be diluted.