Part 3

Then, too, radioactive minerals may be spread widely, but they are not spread evenly. Where they are concentrated to a greater extent than usual, background radiation is abnormally high.

Thus, an inhabitant of Harrisburg, Pennsylvania, may absorb 2.64 rads per 30 years, while one of Denver, Colorado, a mile high at the foot of the Rockies, may absorb 5.04 rads per 30 years. Greater extremes are encountered at such places as Kerala, India, where nearby soil, rich in thorium minerals, so increases the intensity of background radiation that as much as 84 rads may be absorbed in 30 years.

In addition to high-energy radiation from the outside, there are sources within the body itself. Some of the potassium and carbon atoms of our body are inevitably radioactive. As much as 0.5 rad per 30 years arises from this source.

Rads and roentgens are not completely satisfactory units in estimating the biological effects of radiation. Some types of radiation—those made up of comparatively large particles, for instance—are more effective in producing ions and bring about molecular changes with greater ease than do electromagnetic radiations delivering equal energy to the body. Thus if 1 rad of alpha particles is absorbed by the body, 10 to 20 times as much biological effect is produced as there would be in the absorption of 1 rad of X rays, gamma rays, or beta particles.

Sometimes, then, one speaks of the _relative biological effectiveness_ (RBE) of radiation, or the _roentgen equivalent, man_ (rem). A rad of X rays, gamma rays, or beta particles has a rem of 1, while a rad of alpha particles has a rem of 10 to 20.

If we allow for the effect of the larger particles (which are not very common under ordinary conditions) we can estimate that the gonads of the average human being receive a total dose of natural radiation of about 3 rems per 30 years. This is just about an irreducible minimum.

Man-made Radiation

Man began to add to the background radiation in the 1890s. In 1895, X rays were discovered and since then have become increasingly useful in medical diagnosis and therapy and in industry. In 1896, radioactivity was discovered and radioactive substances were concentrated in laboratories in order that they might be studied. In 1934, it was found that radioactive forms of nonradioactive elements (_radioisotopes_) could be formed and their use came to be widespread in universities, hospitals, and industries.[4]

Then, in 1945, the nuclear bomb was developed. With the uranium or plutonium fission that produces a nuclear explosion, there is an accompaniment of intense gamma radiation. In addition, a variety of radioisotopes are left behind in the form of the residue (_fission fragments_) of the fissioning atoms. These fission fragments are distributed widely in the atmosphere. Some rise high into the stratosphere and descend (as _fallout_) over the succeeding months and years.[5]

It is hard to try to estimate how much additional radiation is being absorbed by human beings out of these man-made sources. Fallout is not uniformly spread over the earth but is higher in those latitudes where nuclear bombs have been most frequently tested. Then, too, people in industries and research who are involved with the use of radioisotopes, and people in medical centers who constantly deal with X rays, are likely to get more exposure than others.

These adjuncts of modern science and medicine are more common and widespread in technologically advanced countries than elsewhere, and nuclear bombs have most often been exploded in just those latitudes where the advanced countries are to be found.

Attempts have been made to work out estimates of this exposure. One estimate, involving a number of technologically advanced countries (including the United States) showed that an average of somewhere between 0.02 and 0.18 rem per year was absorbed, as a result of radiations (usually X rays) used in medical diagnosis and therapy. Occupational exposure added, on the average, not more than 0.003 rem, though the individuals constantly exposed in the course of their work would naturally absorb considerably more than this overall average.

On the whole, the highest absorption was found, as was to be expected, in the United States.

If these findings are expanded to cover a 30-year period, assuming the absorption will remain the same from year to year, it turns out that the average absorption of man-made radiation in the nations studied varies from 0.6 rem to 5.5 rems per 30 years per individual.

Considering the higher figure to be applicable to the United States, it would seem that man-made radiation from all sources is now being absorbed at nearly twice the rate that natural radiation is. To put it another way, Americans are just about tripling their radiation dosage by reason of the human activities that are now adding man-made radiation to the natural supply. By far the major part of this additional dosage is the result of the use of X rays in searching for decayed teeth, broken bones, lung lesions, swallowed objects, and so on.

DOSE AND CONSEQUENCE

Radiation Sickness

The danger to the individual as a result of overexposure to high-energy radiation was understood fairly soon but not before some tragic experiences were recorded.

One of the early workers with radioactive materials, Pierre Curie, deliberately exposed a patch of his skin to the action of radioactive radiations and obtained a serious and slow-healing burn. His wife, Marie Curie, and their daughter, Irène Joliot-Curie, who spent their lives working with radioactive materials, both died of leukemia, very possibly as the result of cumulative exposure to radiation. Other research workers in the field died of cancer before the full necessity of extreme caution was understood.

The damage done to human beings by radiation could first be studied on a large scale among the survivors of the nuclear bombings of Hiroshima and Nagasaki in 1945. Here marked symptoms of _radiation sickness_ were observed. This sickness often leads to death, though a slow recovery is sometimes possible.

In general, high-energy radiation damages the complex molecules within a cell, interfering with its chemical machinery to the point, in extreme cases, of killing it. (Thus, cancers, which cannot safely be reached with the surgeon’s knife, are sometimes exposed to high-energy radiation in the hope that the cancer cells will be effectively killed in that manner.)

The delicate structure of the genes and chromosomes is particularly vulnerable to the impact of high-energy radiation. Chromosomes can be broken by such radiation and this is the main cause of actual cell death. A cell that is not killed outright by radiation may nevertheless be so damaged as to be unable to undergo replication and mitosis.

If a cell is of a type that will not, in the course of nature, undergo division, the destruction of the mitosis machinery is not in itself fatal to the organism. A creature like _Drosophila_, which, in its adult stage, has very few cell divisions going on among the ordinary cells of its body, can survive radiation doses a hundred times as great as would suffice to kill a man.

In a human being, however—even in an adult who is no longer experiencing overall growth—there are many tissues whose cells must undergo division throughout life. Hair and fingernails grow constantly, as a result of cell division at their roots. The outer layers of skin are steadily lost through abrasion and are replaced through constant cell division in the deeper layers. The same is true of the lining of the mouth, throat, stomach, and intestines. Too, blood cells are continually breaking up and must be replaced in vast numbers.

If radiation kills the mechanism of division in only some of these cells, it is possible that those that remain reasonably intact can divide and eventually replace or do the work of those that can no longer divide. In that case, the symptoms of radiation sickness are relatively mild in the first place and eventually disappear.

Past a certain critical point, when too many cells are made incapable of division, this is no longer possible. The symptoms, which show up in the growing tissues particularly (as in the loss of hair, the misshaping or loss of fingernails, the reddening and hemorrhaging of skin, the ulceration of the mouth, and the lowering of the blood cell count), grow steadily more severe and death follows.

Radiation and Mutation

Where radiation is insufficient to render a cell incapable of division, it may still induce mutations, and it is in this fashion that skin cancer, leukemia, and other disorders may be brought about.[6]

Mutations can be brought about in the sex cells, too, of course, and when this happens it is succeeding generations that are affected and not merely the exposed individual. Indeed, where the sex cells are concerned, the relatively mild effect of mutation is more serious than the drastic one of nondivision. A fertilized ovum that cannot divide eventually dies and does no harm; one that can divide but is altered, may give rise to an individual with one of the usual kinds of major or minor physical defects.

The effect of high-energy radiation on the genetic mechanism was first demonstrated experimentally in 1927 by Muller. Using _Drosophila_ he showed that after large doses of X rays, flies experienced many more lethal mutations per chromosome than did similar flies not exposed to radiation. The drastic differences he observed proved the connection between radiation and mutation at once.

Later experiments, by Muller and by others, showed that the number of mutations was directly proportional to the quantity of radiation absorbed. Doubling the quantity of radiation absorbed doubled the number of mutations, tripling the one tripled the other, and so on. This means that if the number of mutations is plotted against the amount of radiation absorbed, a straight line can be drawn.

It is generally believed that the straight line continues all the way down without deviation to very low radiation absorptions. This means there is no “threshold” for the mutational effect of radiation. No matter how small a dosage of radiation the gonads receive, this will be reflected in a proportionately increased likelihood of mutated sex cells with effects that will show up in succeeding generations.

In this respect, the genetic effect of radiation is quite different from the somatic effect. A small dose of radiation may affect growing tissues and prevent a small proportion of the cells of those tissues from dividing. The remaining, unaffected cells take up the slack, however, and if the proportion of affected cells is small enough, symptoms are not visible and never become visible. There is thus a threshold effect: The radiation absorbed must be more than a certain amount before any somatic symptoms are manifest.

Matters are quite different where the genetic effect is concerned. If a sex cell is damaged and if that sex cell is one of the pair that goes into the production of a fertilized ovum, a damaged organism results. There is no margin for correction. There is no unaffected cell that can take over the work of the damaged sex cell once fertilization has taken place.

Suppose only one sex cell out of a million is damaged. If so, a damaged sex cell will, on the average, take part in one out of every million fertilizations. And when it is used, it will not matter that there are 999,999 perfectly good sex cells that might have been used—it was the damaged cell that _was_ used. That is why there is no threshold in the genetic effect of radiation and why there is no “safe” amount of radiations insofar as genetic effects are concerned. However small the quantity of radiation absorbed, mankind must be prepared to pay the price in a corresponding increase of the genetic load.

If the straight line obtained by plotting mutation rate against radiation dose is followed down to a radiation dose of zero, it is found that the line strikes the vertical axis slightly above the origin. The mutation rate is more than zero even when the radiation dose is zero. The reason for this is that it is the dose of man-made radiation that is being considered. Even when man-made radiation is completely absent there still remains the natural background radiation.

It is possible in this manner to determine that background radiation accounts for considerably less than 1% of the spontaneous mutations that take place. The other mutations must arise out of chemical misadventures, out of the random heat-jiggling of molecules, and so on. These, it can be presumed, will remain constant when the radiation dose is increased.

This is a hopeful aspect of the situation for it means that, if the background radiation is doubled or tripled for mankind as a whole, only that small portion of the spontaneous mutation rate that is due to the background radiation will be doubled or tripled.

Let us suppose, for instance, that fully 1% of the spontaneous mutations occurring in mankind is due to background radiation. In that case, the tripling of the background radiation produced in the United States by man-made causes (see Table) would triple that 1%. In place of 99 non-radiational mutations plus 1 radiational, we would have 99 plus 3. The total number of mutations would increase from 100 to 102—an increase of 2%, not an increase of 200% that one would expect if all spontaneous mutations were caused by background radiation.

RADIATION EXPOSURES IN THE UNITED STATES[7] Millirems[8]

Natural Sources A. External to the body 1. From cosmic radiation 50.0 2. From the earth 47.0 3. From building materials 3.0 B. Inside the body 1. Inhalation of air 5.0 2. Elements found naturally in human tissues 21.0 Total, Natural sources 126.0 Man-made Sources A. Medical Procedures 1. Diagnostic X rays 50.0 2. Radiotherapy X ray, radioisotopes 10.0 3. Internal diagnosis, therapy 1.0 Subtotal 61.0 B. Atomic energy industry, laboratories 0.2 C. Luminous watch dials, television tubes, 2.0 radioactive industrial wastes, etc. D. Radioactive fallout 4.0 Subtotal 6.2 Total, man-made sources 67.2 Overall total 193.2

Dosage Rates

Another difference between the genetic and somatic effects of radiation rests in the response to changes in the rate at which radiation is absorbed. It makes a considerable difference to the body whether a large dose of radiation is absorbed over the space of a few minutes or a few years.

When a large dose is absorbed over a short interval of time, so many of the growing tissues lose the capacity for cell division that death may follow. If the same dose is delivered over years, only a small bit of radiation is absorbed on any given day and only small proportions of growing cells lose the capacity for division at any one time. The unaffected cells will continually make up for this and will replace the affected ones. The body is, so to speak, continually repairing the radiation damage and no serious symptoms will develop.

Then, too, if a moderate dose is delivered, the body may show visible symptoms of radiation sickness but can recover. It will then be capable of withstanding another moderate dose, and so on.

The situation is quite different with respect to the genetic effects, at least as far as experiments with _Drosophila_ and bacteria seem to show. Even the smallest doses will produce a few mutations in the chromosomes of those cells in the gonads that eventually develop into sex cells. The affected gonad cells will continue to produce sex cells with those mutations for the rest of the life of the organism. Every tiny bit of radiation adds to the number of mutated sex cells being constantly produced. There is no recovery, because the sex cells, after formation, do not work in cooperation, and affected cells are not replaced by those that are unaffected.

This means (judging by the experiments on lower creatures) that what counts, where genetic damage is in question, is not the rate at which radiation is absorbed but the total sum of radiation. Every exposure an organism experiences, however small, adds its bit of damage.

Accepting this hard view, it would seem important to make every effort to minimize radiation exposure for the population generally.

Since most of the man-made increase in background radiation is the result of the use of X rays in medical diagnosis and therapy, many geneticists are looking at this with suspicion and concern. No one suggests that their use be abandoned, for certainly such techniques are important in the saving of life and the mitigation of suffering. Still, X rays ought not to be used lightly, or routinely as a matter of course.

It might seem that X rays applied to the jaw or the chest would not affect the gonads, and this might be so if all the X rays could indeed be confined to the portion of the body at which they are aimed. Unfortunately, X rays do not uniformly travel a straight line in passing through matter. They are scattered to a certain extent; if a stream of X rays passes through the body anywhere, or even through objects near the body, some X rays will be scattered through the gonads.

It is for this reason that some geneticists suggest that the history of exposure to X rays be kept carefully for each person. A decision on a new exposure would then be determined not only by the current situation but by the individual’s past history.

Such considerations were also an important part of the driving force behind the movement to end atmospheric testing of nuclear bombs. While the total addition to the background radiation resulting from such tests is small, the prospect of continued accumulation is unpleasant.

What’s more, whereas X rays used in diagnosis and therapy have a humane purpose and chiefly affect the patient who hopes to be helped in the process, nuclear fallout affects all of humanity without distinction and seems, to many people, to have as its end only the promise of a totally destructive nuclear war.

It is not to be expected that the large majority of humanity that makes up the populations outside the United States, Great Britain, France, China, and the Soviet Union can be expected to accept stoically the risk of even limited quantities of genetic damage, out of any feeling of loyalty to nations not their own. Even within the populations of the three major nuclear powers there are strong feelings that the possible benefits of nuclear testing do not balance the certain dangers.

Public opinion throughout the world is a key factor, then, in enforcing the Nuclear Test Ban Treaty, signed by the governments of the United States, Great Britain, and the Soviet Union on October 10, 1963.

Effects on Mammals

Although genetic findings on such comparatively simple creatures as fruit flies and bacteria seem to apply generally to all forms of life, it seems unsafe to rely on these findings completely in anything as important as possible genetic damage to man through radiation. During the 1950s and 1960s, therefore, there have been important studies on mice, particularly by W. L. Russell at Oak Ridge National Laboratory, Oak Ridge, Tennessee.

While not as short-lived or as fecund as fruit flies, mice can nevertheless produce enough young over a reasonable period of time to yield statistically useful results. Experimenters have worked with hundreds of thousands of offspring born of mice that have been irradiated with gamma rays and X rays in different amounts and at different intensities, as well as with additional hundreds of thousands born to mice that were not irradiated.

Since mice, like men, are mammals, results gained by such experiments are particularly significant. Mice are far closer to man in the scheme of life than is any other creature that has been studied genetically on a large scale, and their reactions (one might cautiously assume) are likely to be closer to those that would be found in man.

Almost at once, when the studies began, it turned out that mice were more susceptible to genetic damage than fruit flies were. The induced mutation rate per gene seems to be about fifteen times that found in _Drosophila_ for comparable X ray doses. The only safe course for mankind then is to err, if it must, strongly on the side of conservatism. Once we have decided what might be safe on the basis of _Drosophila_ studies, we ought then to tighten precautions several notches by remembering that we are very likely more vulnerable than fruit flies are.

Counteracting the depressing nature of this finding was that of a later, quite unexpected discovery. It was well established that in fruit flies and other simple organisms, it was the total dosage of absorbed radiation that counted and that whether this was delivered quickly or slowly did not matter.

This proved to be _not_ so in the case of mice. In male mice, a radiation dose delivered at the rate of 0.009 rad per minute produced only from one-quarter to one-third as many mutations as did the same total dose delivered at 90 rads per minute.

In the male, cells in the gonads are constantly dividing to produce sex cells. The latter are produced by the billions. It might be, then, that at low radiation dose rates, a few of the gonad cells are damaged but that the undamaged ones produce a flood of sperm cells, “drowning out” the few produced by the damaged gonad cells. The same radiation dose delivered in a short time might, however, damage so many of the gonad cells as to make the damaged sex cells much more difficult to “flood out”.