Part 3

16. Bruere, J. Anat. Physiol., Oct., (1891).

17. T. W. Clarke & W. H. Hurtley, J. Physiol., 36, 62 (1907).

18. Hugo Bauer, Ber., 47, 1873 (1914).

19. Ehrlich & Guttmann, Berl. klin. Woch. (1891) 28; U. S. Disp., 20th Edition.

20. P. Karrer, 49, 597 (1916); Ber., 51, 190 (1918).

21. Hugo Bauer, Ber., 47, 1873 (1914); D. R. P., 261,969; Friedl., 11, 1124 (1913).

22. Selenazines, D. R. P., 280,713; 261,793.

23. U. S. Disp., 20th Edition.

24. D. R. P., 305,262; 305,263; Am. Chem. Abs., 13,325 (1918).

25. Bull. soc. chim., 41, 599; Compt. rend., 99, 1154-7 (1885); Brit. Chem. Abs., 50, 376 (1885); A. Ch., (6) 9, 294, 303, 323.

26. W. Baringer, Ber., 23, 1003 (1889).

27. P. Spica, Gazz. chim. ital., 7, 90-9 (1877); Brit. Chem. Abs., (1877) II, 189; Compt. rend., 99, 1154 (1884); 100, 1296 (1885); Frerichs, Arch. Pharm., 241, 180, 196; Beil., (1921) III, 295, 261.

28. C. Paal, Ber., 18, 2255 (1885); Gazz. chim. ital., (I. Zoppellari) 24, II, 399, (1894).

29. Ida Foa, Gazz. Chim. ital., 39, II, 527, (1909); C-B., (1910) I, 837.

30. D. R. P., 264,139.

31. O. Hinsberg, Ber., 22, 862, 2895 (1889); D. R. P., 261,412.

32. J. prakt. Chem., (1904) II, 69, 509.

33. E. Abderhalden, Hand. Biol. Chem., III, 2, 954.

34. Hanzlik & Tarr, Am. Univ. Ezpt. Sta., J. Pharmacol, 14, 221-8 (1919).

35. Hochst, D. R. P., 299,510.

36. D. R. P., 264,940; 264,961.

37. A. Michaelis & M. Stein, Ann., 320, 32 (1902).

38. Bogert & Hand, J. Am. Chem. Soc., 25, 377 (1902).

39. B. Bathke, Ann., 152, 210 (1869); Ann., 185, 331; Richter, Organische Chemie, I, 166.

40. Lesser & Schoeller, Ber., 47, 2293 (1914).

41. Lesser & Weiss, Ber., 45, 1835 (1912); 46, 2653, (1913).

42. Wohler & Dean, Ann., 97, 5 (1856); B. Rathke, Ann., 152, 211 (1869).

43. Cahours, Ann., 61, 92, (1847); 92, 356.

44. H. Klinger, Ber., 32, 2195, (1899); Ann., 119, 91; 121, 108.

45. C. A. Joy, Ann., 86, 35, (1853); B. Rathke, Ann., 152, 212, 219 (1869).

46. Wheeler, Z. Chem., (1867) 436.

47. Krafft & Lyons, Ber., 27, 1762 (1894); A. Ch., (6), 20, 228.

48. K. A. Hoffmann, Ber., 27, 2809 (1894).

49. M. Busch, Ber., 25, 2853, (1892).

50. Lellmann & Stickel, Ber., 19, 1605 (1886).

51. B. Rathke, Ann., 152, 201 (1869).

52. Gabriel & Stelzner, Ber., 29, 1313 (1896).

53. Bogert, Breneman, & Hand, J. Am. Chem. Soc., 25, 373 (1903).

54. Am. Chem. Abs., 3, 870 (1903); Bull. Belg. Soc. Chem., 23, 9-11.

55. Bogert & Hand, J. Am. Chem. Soc., 24, 1035, (1902).

56. Becker & Meyer, Ber. 37, 2551 (1914).

57. H. Bauer, Ber. 48, 507 (1915); Lyons & Shinn, J. Am. Chem. Soc. 1902: 1092; Fritz von Konek & O. Schleifer, Ber. 51, 850 (1918); A. Michaelis, Ber. 30, 2827 (1897); Ber. 48, 873 (1915); H. Frerichs, Arch. Pharm. 1902: 240, 656.

58. Fromm & Martin, Ann., 401, 178 (1913).

VITA

Yü-Gwan Chen was born in Nanking, China, March 8, 1893. After graduation from college in 1915, he further studied Chinese classics, 1915-16. He entered Case School of Applied Science, Cleveland, Ohio, as a special student in the Department of Chemistry, 1916-17. He registered at Columbia University to pursue graduate work in chemistry under the Faculty of Pure Science; and was awarded the degree of Master of Arts in 1918. From September 1919 to June 1922, he has been pursuing research in organic chemistry in the research laboratories of Havemeyer Hall, Columbia University.

FOOTNOTES:

[A] Not a new compound but prepared by a different method.

[B] Note--dimethyl selenophene, however, is colorless.

Transcriber's notes:

The diagram of 3-(p-phenylarsonic)-aminoselenazine, labelled (II), has been adjusted to make its structure clearer.

The "l" in "2HCl" in the first equation under "Preparation of 2-methyl-4-selenoquinazolone" was missing in the original.

The following is a list of changes made to the original. The first line is the original line, the second the corrected one.

selnoquinazolone prepared in the course of this research selenoquinazolone prepared in the course of this research

on four different strains of mouse carcenoma and one strain on four different strains of mouse carcinoma and one strain

in consequence of its smell I so completely loss my sense of smell in consequence of its smell I so completely lost my sense of smell

of the phenazine, oxasine, thiazine, acridine series show of the phenazine, oxazine, thiazine, acridine series show

and Se again most powerful of the whole series. and :Se again most powerful of the whole series.

simplicity, is that of Babriel and Stelzner(52), simplicity, is that of Gabriel and Stelzner(52),

on cooling was filtered out and recrystalized from dilute alcohol. on cooling was filtered out and recrystallized from dilute alcohol.

It was prepared from Sodium hydroxide in absolute alcohol It was prepared from sodium hydroxide in absolute alcohol

a sealed tube at 110° with alcohol saturated at zero degree with a sealed tube at 110° with alcohol saturated at zero degrees with

took an hour and half. The flask was removed from the oil took an hour and a half. The flask was removed from the oil

The precipitrate was recrystallized several times The precipitate was recrystallized several times

(e) An attempt was made to make o-aminobenzselenamide, (e) An attempt was made to make o-aminobenzoselenamide,

It dissolves readily in alkalies and is slightly soluble It dissolves readily in alkalis and is slightly soluble

This was found to be desirable when the dinitroselezazole was burned. This was found to be desirable when the dinitroselenazole was burned.

into a large volume of water when the selenozole precipitated out into a large volume of water when the selenazole precipitated out

it was necessary to dissolve in hot HCl again and to recrystalize. it was necessary to dissolve in hot HCl again and to recrystallize.

(b) 106 grams of benaldehyde were heated with 93 grams of (b) 106 grams of benzaldehyde were heated with 93 grams of

It is difficulty soluble in ethyl alcohol, ethyl acetate, and It is difficultly soluble in ethyl alcohol, ethyl acetate, and

toluene, benzene, alcohol, and difficulty soluble when cold. toluene, benzene, alcohol, and difficultly soluble when cold.

from alcohol in fine yellowish needles, melting at 201.2°202.3°C from alcohol in fine yellowish needles, melting at 201.2°-202.3°C

carbontetrachloride, acetone, but difficulty soluble in ligroin. carbontetrachloride, acetone, but difficultly soluble in ligroin.

19 grams of nitric and 30 grams of sulphuric acids was introduced 19 grams of nitric and 30 grams of sulphuric acids) was introduced

in the same manner as the reduction of mononitro derivative in the same manner as the reduction of the mononitro derivative

This diamino compound crystalizes in yellowish glistening needles This diamino compound crystallizes in yellowish glistening needles

compounds were also prepared from this diamino derivatives. compounds were also prepared from these diamino derivatives.

The former crystalizes in cubes from dilute alcohol; The former crystallizes in cubes from dilute alcohol;