Chapter 37

The structure of this tumor is after the type of gland tissue. It is rarely seen in cattle except in combination with cancer or sarcoma. A growth which occurs more frequently in bovines, especially calves, and which in some instances bears a striking resemblance to an adenoma is the so-called goiter.

GOITER (STRUMA).

This is a noninflammatory enlargement or a hyperplasia of the thyroid gland. While it can not be definitely classed among tumors, yet, owing to its resemblance to the latter, it will be discussed at this time. The cause of goiter has never been definitely ascertained. Among the most probable causes may be mentioned heredity, insufficient and improper diet, close confinement, unhygienic surroundings, and an unknown toxic substance which is supposed to obtain in those localities rich in magnesium and lime salts. Certain organisms found in goiter have been suspected of producing this trouble, but their relation to the disease has not been satisfactorily proved. A goiter may consist of (1) simple enlargement of the follicles which are filled with albuminous matter (follicular goiter); (2) an increase of connective tissues between the follicles, causing the swelling to be dense and resistant (fibrous goiter); (3) a great increase in size of one or more follicles, forming a cyst (cystic goiter); (4) great dilatation of the blood vessels in the gland accompanied with pulsation with each heart beat (vascular goiter).

_Symptoms._--Goiter may be observed at the side of the throat, reaching the size of a fist or even larger, or it may hang down below the windpipe. In cattle the two thyroid glands are close together, and when the disease affects both there may be but one uniform swelling placed in front of the windpipe below the angle of the jaw. This swelling may be hard, soft, or doughy in consistence, and with each beat of the heart it may pulsate like an artery. It may cause labored breathing by pressure on the windpipe, and death may result from pressure on this structure, on the gullet, or on the adjoining large vessels.

_Treatment._--In young animals the treatment is usually satisfactory, and consists in giving the animal a complete change of feed and plenty of exercise in the open air. If the condition appears enzootic in the district, remove the animal to another location when possible. Iodin, either in the form of ointment or the tincture, should be applied to the swelling. Injections of iodin solution, 5 grains of iodin in 1 dram of 25 per cent alcohol, may also be made into the substance of the gland. When the swelling which follows this injection has subsided it may be repeated. Potassium iodid should be given internally in 1-1/2 dram doses twice daily for a cow, or in 20-grain doses twice a day for a calf. Extirpation of all but a small section of the swelling may be successfully accomplished by a qualified veterinarian, but if it should be entirely removed, myxedema and death follow.

FIBROMA.

Fibromas are tumors made up chiefly of connective tissue and are usually confined to the skin and subcutaneous tissue. Indurative fibromas of the skin appear as tumors of gelatinous connective tissue or as firm, white vascular connective tissue growths, which are more or less sharply outlined, move readily over the underlying tissues in company with the skin, and owe their origin to mechanical injuries, perforating wounds, repeated abrasions, or the invasion of pus cocci or botryomyces into the tissues.

These tumors in cattle are frequently found upon the dewlap as solid lumps, hard as stone to the touch, lying loosely between the layers of skin, and gradually losing themselves in the softer tissues of the neck above, or as smooth, hard tumors of glistening white substance with interlacing lines of softer tissue. They may also be found in the region of the knee or at the elbow. The skin over the growths, in accordance with the originating cause, will be found chafed, covered with scabs, or even ulcerated and accompanied with collateral edema.

These connective tissue tumors grow slowly but reach enormous size. They sometimes follow injuries to the region of the throat and form there as hard, firm growth, even reaching the size of a child's head.

A fibroma upon the larynx is not an infrequent occurrence in the ox. These tumors are always sharply outlined and have a roughened surface. They may be differentiated from actinomycotic tumors (see chapter on "Infectious diseases of cattle," p. 358) in the same location by their firm, fibrous structure and by the absence of pus from the interior.

A tumor is sometimes seen upon the muzzle of cattle, which assumes a diameter equaling the width of the muzzle. It is a voluminous connective-tissue formation known by the name of "fibroma diffusum."

Another form is sometimes observed upon the tongue. It grows upon a broad, spreading base, becoming very hard. It is almost lacking in blood vessels, although the few that are present are plainly in view, and in consequence is poorly supplied with fluids. It is of a smooth contour, white or whitish yellow in color, is sharply limited from the normal substance of the tongue, may be covered with mucous membrane, on which prominent papillÊ are located, or only by a thin, delicate layer of epithelium, and is usually found in the middle part of the tongue, where it may reach the size of two fists.

Pedunculate or stemmed fibrous tumors are frequently noticed growing upon or near the extremity of the tails of cows. They are apparently of traumatic origin, such as tying the tail fast while milking or shaving it too closely while trimming for show purposes, and usually contain bloody or gelatinous material within, or, again, they may be strongly edematous throughout.

_Treatment._--The treatment of large fibromas is surgical and consists of the operative removal of the tumor, followed by suturing of the wound. Small external tumors may be painted with zinc chlorid, chromic acid, or a concentrated solution of bichlorid of mercury.

PAPILLOMA (WART).

When fibromas develop from the lining or covering tissues they frequently form papillary growths, more or less thickly covered with epithelium, and are then called papillomas, or warts.

Papillomas consist of villouslike projections, resulting from a proliferation of the outer layer (epithelium) of the skin or mucous membrane. These growths are also called "angle berries," and may assume a variety of forms. Sometimes there is a preponderance of epidermis in the formation, and the tumor then appears as a hard, dense, insensitive, clublike growth, or wart. Again the swelling is chiefly in the derm, or true skin, and we have what is known as a flesh wart (verucca carnea). In other cases the growth of papillar bodies projects in great cauliflowerlike tumors with deeply furrowed and lobulated surface, over which a covering of epidermis may or may not be present. These are usually much softer and are well supplied with blood vessels. It is not uncommon for them to be pedunculate or stemmed, and in this case considerable rotary motion or twisting is possible. Their color is cloudy gray or grayish red, with white bands of connective tissue radiating from the center. Their consistence varies. Upon their surfaces and within their clefts and fissures they undergo retrogressive changes, softening, bleeding, or ulcerations.

A favorite location for the papilloma in cattle is the udder and teats, where they may develop in such numbers as to cover the entire surface and make the animal troublesome to milk. The sides of the head, neck, and shoulders also afford satisfactory conditions for their growth, and are frequently seen to be affected by them.

_Treatment._--Warts may be removed with the scissors, twisted off with the fingers, or ligatured by means of a rubber band or horsehair. The roots should then be cauterized with tincture of iron, glacial acetic acid, or lunar caustic. Acids should never be used in removing warts about the eyes or in the mouth. Papillomas of the eyelids sometimes change to cancers and should be removed by taking out a wedge-shaped section of the eyelid. Young cattle should be given arsenic internally in the form of Fowler's solution, 1 tablespoonful twice a day for a 6-months-old calf.

POLYPS.

Polyps are usually fibromas or myxomas, occurring on the mucous membrane of the nasal passages or genital tract. They grow upon a narrow stem, bleed readily when injured, and often contain a center of thin, limpid fluid. A bloody discharge is sometimes seen coming from the affected nostril, but this is not always easy of detection in cattle, owing to the pliancy of their tongues and to their habit of licking an irritated nostril. Usually these tumors grow downward and may project from the nostril, causing snoring sounds and uneasy breathing. They may occasionally force themselves backward into the throat, where they interfere seriously with respiration, the patient being obliged to breathe with an effort, and even forced to cough in order to dislodge temporarily the obstruction from the larynx. Such tumors, when near the nostril, may easily be removed by the use of forceps or a loop made of bailing wire. Serious bleeding is not liable to follow their removal, but an astringent wash, such as a solution of the perchlorid of iron, if applied to the cut surface, will be found very beneficial. In case the tumor is not within easy reach, the services of a qualified veterinarian should be obtained to perform the necessary operation.

LIPOMA.

This is a tumor consisting chiefly of fat cells. The growth is irregularly rounded and distinctly lobulated, very soft, and almost fluctuating. It is insensitive, grows slowly, and is always inclosed in a distinct fibrous capsule, from which it can be easily shelled out. It may become very large and often hangs pendulous from a long, elastic pedicle. In cattle this tumor may be found in the subcutaneous tissues, especially of the back and shoulders, uterus, and intestines, and in the latter position it may cause strangulation, or "gut tie," by winding around a loop of the intestine.

_Treatment._--When found on the skin the tumor may be readily removed with a knife or by a ligature. Caustics and the cautery produce wounds that heal slowly and can not be recommended in the treatment of this tumor.

CHONDROMA.

This tumor formation is composed of cartilage cells. It is a rounded and very often unevenly nodular and sharply described tumor. It is very hard, dense, elastic, and painless and develops principally where we find normal cartilage cells. It is rare in cattle, but has been found in the subcutaneous tissues and nasal cavities.

_Treatment._--Extirpation.

OSTEOMA (BONY TUMOR).

Bones may occasionally grow in such a profuse and irregular manner that the product, or osteophyte, assumes the character of a tumor. The bone tissue may possess either spongy or compact properties and grow either from the periphery of the bone or within its interior. These tumors most frequently appear about the head of the animal, either upon the jawbones, within the nasal passages, or in connection with the horns. They are usually of bony hardness, painless, benign, and sharply outlined.

_Treatment._--The treatment consists in either removing them with a saw, chisel, or trephine, or preventing their further development by counterirritation with blisters or firing iron.

MYXOMA.

Characteristic myxomas are mucoid tumors which chiefly originate from the mucous membrane and are especially to be found within the nasal passages and uteri of cattle. They can reach a size of three fists, are smooth or velvetlike, or may be lobulated, broad at the base, and consist of a glassy-looking mass of connective tissue, which usually shows a distinctive yellowish color. Being homogeneous and elastic, the moist, jellylike tissue composing the tumor may be easily destroyed or crushed. When cut through, these tumors soon collapse from the loss of their fluids. They sometimes inclose elliptical cavities filled with slimy, gelatinous masses.

_Treatment._--Extirpation.

SARCOMA.

This is a malignant tumor after the type of embryonal tissue, and consists of several varieties, such as the round cell, spindle cell, giant cell, alveolar, and melanosarcoma. They grow by preference in connective tissue and are quite vascular. Sarcomas appear either as single or multiple nodules, varying in size from a hempseed to a hazelnut, or else as a moderate number of tumors of the size of hen eggs. Their surface, at first smooth, later becomes lumpy and tuberous from internal degeneration. Secondary nodules may appear near the primary tumor. The outer skin is not involved so soon as in cancer, nor does ulceration follow so rapidly. Sarcoma is about the most frequent and dangerous tumor that is found in cattle. It occurs in young animals, and is found on the serous membranes, in the glandular organs, and on the outer skin, especially of the neck and shoulders--in fact, in nearly every tissue and in almost every part of the body. This tumor is often found in places exposed to traumatisms and at seats of scars, or of irritations from pressure and inflammation.

_Treatment._--Treatment should consist in early and complete removal by the knife, including one-half or three-quarters of an inch of the sound tissue adjoining the tumor. If there is a possibility that sarcomatous tissue still remains, either cauterize the wound with a hot iron or powder the walls of the cavity with arsenious acid.

CANCER (CARCINOMA).

Cancers are tumors of epithelial tissues and are malignant. There are several varieties of cancers, such as hard, soft, and colloid, but only those growing on the surface will be mentioned here. These malignant tumors of the superficial organs develop primarily from the epidermis or from the glands of the skin. They appear secondarily as spreading infections from milk glands, thyroids, anal glands, or as embolisms. In such cases their sole character depends wholly upon the kind of cancer from which they have sprung. The infiltrating cancer begins as an elevation of the skin, which progresses until it becomes rough and nodular. The surface later becomes attacked, and an ulcer results whose edges are outlined by a hard, firm zone.

The ulcerations may remain limited by cicatricial tissue, but it is more likely that the infiltration and destruction of tissue will spread out wider and deeper until a rodent ulcer (so called) is formed. One of the most frequent sites of cancer in cattle is in the eye, where they are called fungus hematodes, but they also occur on the skin, on the genitals, in the stomach, and within the organs.

_Fungus hematodes._--This starts at the inner corner of the eye as a papillary elevation or as small nodules which become fused. They grow larger and become papillomatous, with superficial ulcerations and a tendency toward hemorrhage. In some cases the eye is displaced by the growing tumor or is attacked by the cancer cells and entirely destroyed.

Cancerous growths upon the external genitals and the anus usually present a rough, irregular surface from which there is a constant sloughing of decomposed tissue accompanied with a penetrating disagreeable odor.

The diagnosis of cancer may be made clinically by noting the simultaneous infection of the lymph glands which surround the primary lesion. Deeply burrowing and infiltrating forms which appear as lumps and ulcerations cause marked disfiguration of the affected part. The surface becomes a soft, greasy mass; later it cracks open and from the fissures blood-colored pus exudes, being continually formed by the moist degeneration of the tissues beneath. At first the general health of the animal does not appear affected, but later the cancer nodules spread to important organs and give rise to marasmus and progressive emaciation. Cancer is not a frequent tumor of cows. Frˆhner states that of 75 cases of tumors in cattle which came under his observation 2, or 2.6 per cent, were found to be cancers, while 20, or 26.6 per cent, were sarcomas.

_Treatment._--Treatment consists in the early and complete removal of the tumor, taking care to include a wide border of healthy tissue. This has been most successful in such superficial cancers as those of the eye, penis, anus, testicle, vulva, and sheath. If the disease has advanced too far, this treatment may not prove efficacious, owing to the great malignancy of the cancer and its tendency to recur. In such cases the animal may be slaughtered, but the flesh should be used for food only after inspection by a competent veterinarian.

CYSTS.

Cysts may be true or false tumors and consist of a capsule containing a fluid or semisolid content. Among the most important cysts, which have been briefly referred to in a previous table, the following are probably the most noteworthy, owing to the frequency with which they are found in bovines:

SOFTENING CYSTS.

Softening cysts, which result from the degenerative liquefaction of normal or diseased tissues, especially of tumors of different kinds, followed by the encapsulation of the fluid.

PARASITIC CYSTS.

Parasitic or foreign-body cysts, from the inflammatory reaction induced by such parasites as the echinococcus (hydatid cyst) or by the presence of various kinds of foreign bodies.

EXTRAVASATION CYSTS.

Extravasation cysts, caused by injuries which rupture blood vessels, followed by an increase of fibrous tissue which forms a capsule about the fluid. The hygromata in front of the knee in cattle, so-called tumor of the knee, and serous cysts belong to this variety.

HYGROMATA, OR TUMORS OF THE KNEE.--These consist in the simplest form of a collection of serous fluid mixed with fibrin within a distended bursa. The walls surrounding the fluid become firm, smooth, and dense.

Outwardly the tumor appears fluctuating, though tense, while the skin which covers it may be normal, denuded of hair, or covered with hard epidermal scales, possibly half an inch in thickness, forming a hard, horny plate. The cavity which contains the fluid may have the dimensions of a hen's egg, an apple, or a child's head. Its walls are formed by the diseased secreting membrane of the bursal sac, and are readily detachable from the subcutis of the skin. Their internal surfaces are often uneven or supplied with projections or tufted growths which support a fibrous network within the tumor.

Tumors of the knee may also assume a granular type, as the result of chronic inflammation or following operative or spontaneous evacuation of pus from the part. They are either firmly connected with the skin or are detachable from it, and when laid open disclose a whitish-red, porklike tissue surrounding a central nucleus of pus, or a fistulous tract leading to the outer surface. They are caused by the chronic inflammation which follows the bruises received by cattle in lying down and in rising, or they may be due to falls on uneven, hard ground.

_Treatment for hygromata._--When the swelling first appears cold water should be applied, followed later by bandaging with cloths wrung out of warm water. If the swelling is soft, it should be punctured at the lowest point, and afterwards the cavity should be syringed with Lugol's solution. If the tumor is hard and nonfluctuating, a mercurial blister may cause absorption and at the same time prevent further injury to the part by making it more painful, thus sparing it.

SEROUS CYSTS.--These swellings are another variety of extravasation cysts, and are caused by such injuries as butting, running against hard objects, and shipping bruises, which are followed by an outpouring of blood and lymph into the tissue spaces. These cysts develop rapidly and may reach the size of a man's head or even larger. They are soft, edematous, and hot at first and contain a serous or blood-tinged fluid. Later, partially organized clots and shreds of a fibrinous nature and of a gelatinous consistence are formed within, and the temperature of the swelling is reduced. They appear on the surface of the body, especially on the belly and flank of cattle.

_Treatment of serous cysts._--Treatment consists in opening the cyst at the most dependent point with a sharp knife. The cavity should be washed out twice daily with a 5 per cent solution of carbolic acid, and drainage encouraged by keeping the incision open.

DERMOID CYSTS.

These cysts have a wall which is almost an exact duplicate of the structure of the skin, and frequently contain epidermal structures, such as hair and teeth, which, in the development of the embryo, have been misplaced. Thus we may find in an ovary or testicle a dermoid cyst, containing a tooth or a ball of hair. Dental cysts are included in the class above.

DENTAL CYSTS.--It happens occasionally that the teeth of cattle, instead of developing normally within strong supporting alveolÊ, remain inclosed within a cystic membrane, which assumes a tumorlike character. One tooth may be included alone in the cyst or a number may be inclosed together. However this may be, the malformation progresses, especially if confined to the incisor teeth, until the remaining teeth that began to develop normally are crowded out of position and rendered useless. The tumor may reach the size of a man's fist. It appears to be fleshy and dents upon pressure, but it may also appear on closer examination as though it contained irregular sections of thin bone. The outer surface is always smooth, and no indication of purulence, softening, or scab formation is ever exhibited. Upon being laid open with the knife the tumor is seen to be surrounded by a firm, smooth membrane which limits it completely from the adjoining tissues. It is filled with material which possesses partly edematous, partly fleshy, and partly bony properties. It is supposed that this mass is composed of rudiments of the jawbone or of the alveolar walls which, becoming spongy, lose themselves in the soft, fleshy mass contained within the capsule of the tumor. It occasionally happens that the tumor is hollow and that the cavity extends back into the body of the lower jaw for a considerable distance.

Tumors of this kind, being of congenital origin, are very naturally observed most frequently in young cattle, but they may continue to expand for a period of several months after the birth of the calf, even until they become troublesome and unsightly.

_Treatment for dental cysts._--Treatment consists in the complete extirpation of the cyst and the destruction of the lining pouch by curetting.

RETENTION CYSTS.

Retention cysts arise from the retention of normal secretions, owing to obstruction of a duct leading from a gland. The mucous cysts found in the mouth, udder, and vestibule of cows are samples of this form.

MUCOUS CYSTS.--Saclike dependent tumors, caused by retention of the secretions from the mucous glands, sometimes develop in the mouth, nose, pharynx, and vulva of cattle. They are called "mucous cysts." These are of sizes varying from peas to pigeon eggs, are roundish and translucent, and surrounded by a delicate, vascular membrane. They contain a siruplike substance more or less thick and transparent and whitish yellow in color.

Treatment consists in the puncturing of the swelling, if accessible, and the destruction of the cyst walls by the injection of Lugol's solution.

PROLIFERATION CYSTS.

These are found especially in the ovaries of cows, called "cystic ovaries," and may produce nymphomania (chronic bulling).

The treatment indicated in this case is the removal of the diseased ovaries.

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