Part 6

There is no record of any disability or symptom of nervous or mental disease at enlistment. The first symptoms were noted by the patient in May, 1916, six months or more after enlistment. The case was reviewed at a Canadian Special Hospital, October 11, 1916, by a board which reported:

“The condition could only come from syphilitic infection of three years’ standing” (a decision bearing on compensation); but the general diagnosis remained:

“Cerebrospinal lues, =aggravated by service=.”

The picture which the medical board regarded as of at least three years’ standing was as follows:

History of incontinence, shooting pains, attacks of syncope, general weakness, facial tremor, exaggerated knee-jerks, pupils react with small excursion. Speech and writing disorder, perception dull, lapses of attention, memory defect, defective insight into nature of disorder, emotional apathy.

1. Was the conclusion “aggravated by service” sound? On humanitarian grounds the victim is naturally conceded the benefit of the doubt. But it is questionable how scientifically sound the conclusion really was.

2. Could the condition come only from syphilitic infection of at least three years’ standing? Hardly any single symptom in this case need be of so long a standing; yet the combination of symptoms seems by very weight of numbers to justify the conclusion of the medical board.

Farrar’s case and thirteen others of “Neurosyphilis and the War” were included in a general work on Neurosyphilis (Case History Series, 1917, Southard and Solomon). For military syphilis in general, see Thibierge’s _Syphilis dans l’Armée_ (also in translation).

General paresis lighted up by the stress of military service without injury or disease?

=Case 9.= (MARIE, CHATELIN, PATRIKIOS, January, 1917.)

In apparently good health a French soldier repaired to the colors, in August, 1914, being then 23 years old.

Two years later, August, 1916, symptoms appeared: speech disorder with stammering, change of character (had become easily excitable), stumbling gait. He became more and more preoccupied with his own affairs, grew worse, and was sent to hospital in October, 1916.

He was then foolish and overhappy, especially when interviewed. There was marked rapid tremor of face and tongue. Speech hesitant, monotonous, and stammering to the point of unintelligibility. His memory, at first preserved, became impaired so that half of a test phrase was forgotten. Simple addition was impossible and fantastic sums would be given instead of right answers. Handwriting tremulous, letters often missed, others irregular, unequal, and misshapen.

Excitable from onset, the patient now became at times suddenly violent, striking his wife without provocation. After visit at home, he would forget to return to hospital. Often he would leave hospital without permission (of course the more surprising in a disciplined soldier). No delusions.

Serum and fluid W. R. positive; albumin; lymphocytosis.

Neurological examination: Unequal pupils, slight right-side mydriasis, pupils stiff to light, weakly responsive in accommodation, reflexes lively, fingers tremulous on extension of arms.

The patient had, December 5, 1916, an epileptiform attack with head rotation, limb-contractions and clonic movements. Should this soldier recover for disability obtained in service? Marie was inclined to think military service in part responsible for the development of the paresis. Laignel-Lavastine thought so also, but that the amount assigned should be 5%-10% of the maximum assignable.

SYPHILITIC ROOT-SCIATICA (lumbosacral radiculitis) in a fireworks man with a French artillery regiment.

=Case 10.= (LONG (DEJERINE’S clinic), February, 1916.)

No direct relation of this example of root-sciatica to the war is claimed nor was there a question of financial reparation.

There was no prior injury. At the end of March, 1915, the workman was taken with acute pains in lumbar region and thighs, and with urgent but retarded micturition.

Unfit for work, he remained, however, five months with the regiment, and was then retired for two months to a hospital behind the lines. He reached the Salpêtrière October 12, 1915, with “double sciatica, intractable.”

There was no demonstrable paralysis but the legs seemed to have “melted away,” _fondu_, as the patient said. Pains were spontaneously felt in the lumbar plexus and sciatic nerve regions, not passing, however, beyond the thighs. These pains were more intense with movements of legs; but coughing did not intensify the pains. Neuralgic points could be demonstrated by the finger in lumbar and gluteal regions and above and below the iliac crests (corresponding with rami of first lumbar nerves). The inguinal region was involved and the painful zone reached the sciatic notch and the upper part of the posterior surface of the thigh.

The sensory disorder had another distribution, objectively tested. The sacral and perineal regions were free. Anesthesia of inner surfaces of thighs, hypesthesia of the anterior surfaces of thighs and lower legs. The anesthesia grew more and more marked lower down and was maximal in the feet, which were practically insensible to all tests, including those for bone sensation. There was a longitudinal strip of skin of lower leg which retained sensation.

Position sense of toes, except great toes, was poor. There was a slight ataxia attributable to the sensory disorder--reflexes of upper extremities, abdominal, and cremasteric preserved, knee-jerks, Achilles and plantar reactions absent.

The vesical sphincter shortly regained its function, though its disorder had been an initial symptom. Pupils normal.

The “sciatica” here affects the lumbosacral plexus.

As to the syphilitic nature of this affection, there had been at eighteen (22 years before) a colorless small induration of the penis, lasting about three weeks. There was now evident a small oval pigmented scar. The patient had married at 20 and had had three healthy children.

The lumbar puncture fluid yielded pleocytosis (120 per cmm.). Mercurial treatment was instituted.

The treatment has not reduced the pains. Long thinks it was undertaken too long (six months) after onset. The warning for early diagnosis is manifest. There was somehow a delay under the medical conditions of the army.

_Re_ syphilis in munition-workers Thibierge has much to say of French conditions. Throughout his work on syphilis in the army, he stresses the large number of venereal cases in men mobilized for munition-work. Medical inspections ought, according to Thibierge, imperatively to be made in the munition-works and upon all mobilized workmen, whether French or belonging to the Colonial contingents. These men are under military control in France, but they have more opportunities than the soldiers for contracting and disseminating syphilis. They are, in point of fact, very often infected and in a higher proportion than are the soldiers at the front. The munition-workers should also be obliged to report their infections to the physician, whether or no they are under treatment by military or by private physicians.

Thibierge devotes a chapter to syphilis as a national danger. Not only do available statistics prove that there is more syphilis in the population since the outbreak of war, but the number of married women going to special hospitals for syphilis is abnormally high and entirely out of proportion to the number of married women resorting to these clinics in peace times. A certain number are contaminated by their husbands on leave. Thibierge calls attention to the fact of the extraordinary frequency of syphilis in young men (two or three, sixteen to eighteen years of age, at Saint-Louis Hospital at each consultation).

A disciplinary case: Syphilitic?

=Case 11.= (KASTAN, January, 1916.)

Reports varied about a certain German soldier who came up for discipline. Inferiors thought he was harsh and tricky. A lieutenant declared that the man always wanted to have proper respect paid to him, and that he was unduly excited by trifles. The man had become latterly very nervous on account of battle strain and protracted shelling.

July 28, 1915, the man, who had been drinking with comrades the night before, was excitedly talking to an officer concerning relief of a guard. The soldier stated, “As a sergeant on duty with a service record of 15 years, I think it is my affair.” The lieutenant replied, “So far as I am concerned, the matter is settled.” The sergeant yelled, “As far as I am concerned, it is settled also. By the way, my name is _Mr._ Vice Sergeant …,” and with that the sergeant wrote down the lieutenant’s words and refused to obey the lieutenant’s order to “Stop writing.” The lieutenant drew his sword and said, “Take your hands down.” The sergeant replied, “Surely I am permitted to write.” Lieutenant: “Subordination; don’t forget yourself, Vice Sergeant.…” The sergeant jeered, “You forgot yourself anyhow;” whereupon the lieutenant: “Well, such a thing never happened to me before.” The sergeant, jeeringly, “Nor to me either. If I were not in undress I should know what to do.” The lieutenant: “Vice Sergeant …, remain here. This matter will be settled at once.” The sergeant: “It is _Mr._ Vice Sergeant …,” whereupon he gave his notebook to a hornblower and said, “Write.” The lieutenant: “Stay.” The sergeant: “What, stay here. No, I’ll not stay,” and made off. The lieutenant called after him, “Put on your service dress and see the captain.” He made ready but said, “This half-idiot gives an order like that to a sergeant with 15 years’ record.”

The examination showed that the man had a hypalgesia. He complained of violent headaches. He said that he had had syphilis 10 years before; there were no bodily stigmata.

Regulations broken: General paresis.

=Case 12.= (KASTAN, January, 1916.)

A German 1st-lieutenant, on active service before the war, had left the service because there was not enough for him to do in peace times. During his war service, he became drunk and had two soldiers bound to a doorpost, with coats unbuttoned and without their caps--a process quite _verboten_. While in Königsberg, he reported himself ill, and failed to go to a designated hospital. He was accordingly treated as a deserter. He ran up bills with landlady and servant girls, saying that he was going to receive money from his wife. Under hospital examination, he said he was only a Baden man with a lively temperament. He got angry at the phrase _test feeding_, refused food, got excited when asked to help in the care of other patients, and wrote a letter saying, “If it is the idea to make me nervous by removing the air from me, by prescribing rest in bed--a punishment only suitable for a boy who cannot keep himself neat--and such chicaneries, these philanthropic attempts are bound to fail on my robust peasant nerves. Of course I know that money considerations make the stay of every paying patient desirable, but I am really too good for that. [The expenses were being borne by the state.] I have openly stated what is being here done with me is foolery, and I stick to that phrase. The food, already poor enough, is no better, when the meat of a half-rotten cow comes twice to the table.” This patient was, according to Kastan, a victim of general paresis.

_Re_ general paresis and delinquency, Gilles de la Tourette long ago maintained that there was a medicolegal period in paresis. Lépine in his work on _Troubles Mentales de la Guerre_ speaks of the unexpected frequency of general paresis in the army, and calls attention at the outset to the medicolegal period. The danger of overt delinquency is, in fact, greater under military than under civilian conditions on account of the closer surveillance of the soldier. Desertion and thievery are the main forms.

Unfit for service: General paresis.

=Case 13.= (KASTAN, January, 1916.)

Kastan describes a non-commissioned officer, who came voluntarily into the clinic. It seems that he had absented himself (?) from the army in the suburbs of Königsberg, September 3, 1914. He was arrested October 7th. Once before he had been brought to Kastan’s clinic on the suspicion of general paresis, but had been dismissed as non-paretic. Brought in again in a condition of marked fear, he declared that he had to fall behind his company while he was on the march on account of a feeling of weakness. He had been taken to a hospital and then carried to the suburbs of Königsberg, examined, and found unfit for service.

He had in his 20th year become infected with syphilis, and had recently become forgetful, subject to fears, and easily excitable. He had been very unhappily married with a woman who was hysterical and threatened to shoot and poison him. He lived in a condition of continual quarrels with her. The symptoms that he felt on the march were numbness of the legs and a rush of blood to the head. In the clinic, he was subject to much dreaming and raving about the war. There was excessive perspiration.

1. As to the proper interpretation of this case, details are lacking as to the physical and laboratory side. In fact, it would appear that the suspicion of paresis at his first reception in a clinic was dismissed without resort to laboratory findings.

There are no neurological symptoms in the case clearly suggestive of neurosyphilis, except perhaps the numbness of the legs. The remainder of the picture appears to be entirely psychic. Sensory and intellectual symptoms are missing unless we count the war dreams and mania as intellectual. It appears wiser to count these as emotional in the sense that they were roused by emotion-laden memories. The fear, perspiration, and feelings of head flush are perhaps to be best interpreted as satellites about an emotional nucleus.

Hysterical chorea versus neurosyphilis.

=Case 14.= (DE MASSARY and DU SONICH, April, 1917.)

There were various complications in the case of a lieutenant (nervous tic in childhood; travel 23 to 30), who was at Antwerp during the period of mobilization. He was taken there by the Germans; was a prisoner in their hands for 55 days; and succeeded under great strain in escaping.

He then entered his regiment, and, passing the examinations, was made an adjutant, and went to the front, March, 1915. He stayed ten months in the Verdun region, under heavy bombardment, and in June was bowled over and buried by a 210. He seemed to be fearless, getting no sensation from shell-bursts except a griping sensation in the bowels.

However, his character had altered in the direction of irritability; and by the end of January, 1916, he had to be evacuated for the first time from the front, for general weakness, with the diagnoses: neurasthenia, neuralgia, dyspeptic troubles, great general fatigue, marked depression. In fact, at Narbonne he was asked no questions for several days on account of his obvious depression. He was given ice-bags for violent headaches, complete rest in bed, cacodylate and sodium nucleinate. In two weeks he was up and about.

At this time appeared choreiform movements, which reached their maximum in two or three days, whereupon he was sent, March 4, 1916, to the neurological centre at Montpellier. Here W. R. positive! Neosalvarsan on the second injection (0.45 and 0.60) yielded a strong reaction, with fever, delirium, vomiting, and then jaundice.

About a month later, he was given twenty more intravenous injections, whereupon the choreic movements now decreased, and July 15 he was given convalescence for three months. October 15 he went back to his dépôt cured; and October 20, on request, went to the front. He was potted and under machine-gun fire at times during the next three months, but the choreic movements did not reappear. January 1 he left the trenches as the division went into billets. January 8, suddenly, without any emotional cause, he began to “dance” again. Accordingly, he was evacuated for the second time, January 10, 1917, with the diagnosis: choreic movements, especially on left; evacuate to special centre.

At Royallieu, a lumbar puncture showed a slight lymphocytosis. The headache improved. He was evacuated January 24, 1917, to Val-de-Grâce, with a diagnosis: Recurrent chorea; first attack followed commotio cerebri, nervous depression, inequality of pupils, various pains, contracted in the army. Another W. R. was positive. Twelve intramuscular injections of oxygen cyanide were given, besides baths. He was then sent to Issy-les-Moulineaux with a diagnosis of tic. He showed choreiform movements affecting the legs alone. When sitting, legs extended and flexed, the knees would abduct, then adduct; the thighs flexed. When standing, flexor movements were produced alternately on the left and the right, the knee being raised high, sometimes striking the patient’s hand. In walking, the thigh and lower leg flexion was always out of proportion to the required step. There was thus a sort of saltatory chorea limited to the legs. The reflexes so far as they could be tested were normal save that the left pupil was fixed to light and accommodation; the right pupil was sluggish to light but accommodated normally. Leucoplakia of the cheeks; nocturnal headaches; and pains resembling lightning pains in arms and legs. Lumbar puncture, March 26, showed blood-stained fluid, and the puncture was followed by headache, vomiting, and slow pulse. The fluid showed a slight lymphocytosis; W. R. negative.

It is clear that a diagnosis limiting itself to the leg trouble would probably content itself with “hysterical chorea.” The lieutenant said that when he saw people “dance” he did have a tendency to imitate them; and when he was cured of that, he did not want to go to Lamalou because he would see the ataxic patients there and might fall back into his “dancing.” However, in view of the pupillary inequality, the lymphocytosis, the leucoplakia, the W. R., and the initial neurasthenia and depression found in the very first hospital in which he was examined, we probably should be entitled to consider that general paresis played a part in the chorea.

Shrapnel fragment driven through skull: General paresis.

=Case 15.= (HURST, April, 1917.)

A private, 31, was wounded December 7, 1916, by a shrapnel fragment which entered the skull above the left ear and lodged in the brain, an inch above and 2½ inches below the middle of the right orbital margin. At Netley, December 30, he proved to show a complete internal and external left sided ophthalmoplegia, with the exception of the external rectus. On the right side, there was a complete paralysis of the superior rectus and a partial paralysis of the inferior rectus and levator palpebrae superioris. There was a paresis of the left side of the face. The right plantar reflex was said to have been extensor at the clearing station, but at Netley it and the other reflexes proved to be normal, as were the optic. The patient was stuporous and had incontinence of urine and feces for two days. Shortly after admission, slurring of speech with a long latent period occurred. It was clear that the shrapnel fragment must have passed far above the crus, and it was not plain how isolated lesions of the third and seventh nerve nuclei could have been brought about without injury of the long tracts of the crus.

The Wassermann reaction of the serum was negative, but that of the spinal fluid was positive. Iodide and mercury secured considerable improvement in the mental condition and some diminution in the paralysis. The patient is now extremely pleased with himself and has a speech suggestive of paresis.

Head trauma: Shell-shock effects, over in a few months. Manic-depressive (?) attack more than two years later. X-ray evidence suggesting brain lesion. Serum Wassermann reaction positive.

=Case 16.= (BABONNEIX and DAVID, June, 1917.)

A bullet glancing from his gun barrel November 28, 1914, wounded a man in the head, whereupon he lost consciousness and was carried to a hospital and trephined. On coming to, he found that he could not hear and felt pains; but the latter disappeared in a few months. He was given sedentary employment and did his work properly until February, 1917, when he suddenly became sad, wept, slept poorly, stopped eating, had an absent air, and began to complain of his head. He passed whole days without moving, in a sort of stupor, which was then followed by a hypomaniacal agitation in which he walked furiously up and down in the room and threw objects about.

He was found subject to a generalized tremor and he was distinctly weaker on the right side. The tendon reflexes were excessive. The bony sensibility, as well as the pain and temperature sense, and the position and stereognostic senses were completely abolished on the right side. The scar lay on the left side. It was deep and very sensitive to pressure, so that if it was touched ever so slightly the patient began to weep. X-ray indicated loss of substance in the posterior part of the left parietal region. Remains of the projectile were found subcutaneously in the right supraorbital region. The W. R. of the serum was positive. There was no lymphocytosis in the spinal fluid.

Interpretation of this case is manifestly difficult. Four possibilities exist: Syphilis, manic depressive psychosis, traumatic brain disease, and functional shock effects. More than two years had passed between the trauma and the change of character.

Skull trauma in a syphilitic.

=Case 17.= (BABONNEIX and DAVID, June, 1917.)

A soldier, 31, sustained fracture of the occiput from shell-burst, and thereafter showed confusion and total loss of memory. Operation November 11 withdrew bony fragments and clots, whereupon the man returned practically to normal. He developed, however, a few seizures, in which he struggled, fell, and lost consciousness, afterward suffering from headache. The tendon reflexes were increased. The occipital cicatrix was a little depressed and slightly painful on pressure.

Lumbar puncture showed a very slight lymphocytosis (5 to 6 cells), practically negative globulin reaction, and a low albumin titer. There were no signs of syphilis in the eyes. The W. R. in the serum was strongly positive. Very possibly the traumatic phenomena in this case can be safely disengaged from the syphilitic phenomena.

_Re_ the mechanism by which trauma evokes or accelerates the course of neurosyphilis, it is probable that most neuropathologists believe that the _commotio cerebri_ causes sundry chemical or physical effects in the nerve tissues such that spirochetes are moved into new and more dangerous places, or such that more appropriate food is supplied to the organisms, which then begin to multiply. Whether the organisms live in a kind of symbiosis in the tissues under ordinary circumstances in the pre-paretic period of the development of neurosyphilis, is unknown. Possibly fat embolism should be added to the list of possible causes of the hastening of the neurosyphilitic process. Fat embolism in the brain has been shown by various authors to be accompanied by minute hemorrhages, in the midst of which by proper stains the fat embolism can be made out.

Shell-wound in battle: General paresis.

=Case 18.= (BOUCHEROT, 1915.)