Part 4

AND the Conjecture that a Sickness amongst Cattle is transferable to the humane Species, hath not yet appeared on any good Foundation; but to remove this Difficulty, no one doubts but that a Plague amongst Cattle, from some common Cause, as a Corruption of the aerial Nitre, and which differs from a Plague amongst Men but in Degree, may also be transmitted to the humane Species; that is, a feebler Degree of Poison, and a milder _Aura_, may taint the Herbage, than that which is sufficient to destroy the firmer Constitution of Animals; besides which, from the Diversity in the Pores of Brutes, and their different Constitutions, and the Fortitude in the Spirit of a Man, I cannot be induced to believe that the Pestilence amongst Cattle from a private Cause, can ever obtain any Dominion over Mankind. These Stories therefore have no Weight with me, that a certain Leech, upon opening an Horse, that with a great many others had died of some common Distemper, in Order to know what it was, and finding certain pestilential Tokens upon his Inwards, both the Master and the Family soon died of the Infection; which yet went no further than that Family, but expired with them.

DURING the late Plague likewise at _London_, a Citizen travelling into the Country, found his Horse of a sudden to tire and fall down, whereupon he opened his Mouth to find out if possible the Cause of so sudden a Change; when the good Man, upon Receipt of the Horse’s Breath upon him, immediately grew sick, and died in two Days Time.

BUT these and the like Instances certainly tend to prove no more than that there may be Constitutions and malignant Steams, which, by agitating the Mass of Humours, may excite putrid and irregular Orgasms, wherein the Juices and Animal Fluids, according to the Quantity and Prevalency of the Distemperature, and the Variety of the infused Taint, with the Diversity of Putrefaction, goes into Corruption; but the forementioned Transplantation of the Plague does not happen but where there is a suitable Predisposition of Humours to admit it, as its Cause is not general.

MOREOVER, although the Intemperature of the Year, sudden Change of Air, Suppression of usual Evacuation, Diminution of Perspiration, Drunkenness, Venery, and Passions of the Mind, especially Anger and Fear, are justly reckoned amongst the remote Causes of a Pestilence; yet they regard rather the Invasion of it, than its Origin; but of this we shall say more hereafter. As to the above-mentioned Passions, it is almost incredible how some, at the Height of the Infection, would from a very slight Cause kindle into the utmost Rage, and rave at one another like meer Scolds, until Death parted their Contentions.

NOR does Fear or Sorrow less prepare the Way for the Infection, by deadning the Fancy and Memory, by Suffocating the Spirits, Suppressing the natural Heat, breaking the Constitution, and Promoting Malignity: We have manifold Instances of this kind in Readiness; but if, as some do, we should be prolix in the Enumeration of Things that want not Proof, the Reader would be quite tired with needless Stories.

BUT now it may be convenient to add a few Remarks concerning the Translation of a Pestilence from an hot Country to a cold one; for according to the different Effects of Heat and Cold, the one attenuating and rarefying, the other condensing and constipating, the pestilential Venom is strangely altered, insomuch that in a Thing so obvious, there does not require much to be said: Every Thing of this kind prodigiously spreads in hot Climates, as being more subtile than even the Air it self; tho’ the same in the Northern Countries is more restrained, and confined in Fastnesses it cannot escape from; and from hence the Reason is very obvious why there is so much Difference between the Diseases of different Climates, which would be too tedious for us here to go into.

TO come nearer therefore to our Business; the same Affections that in an hot Country heat the Blood and other Juices, so as in a great Measure to put them into Fusion, when translated into the contrary Extream may give contrary Properties to the same Fluids, and _è contra_; and this might be demonstrated by innumerable Experiments, were there any Doubt about it.

IT being then granted, that this Plague first was brought from _Africa_, or _Asia_, to _Holland_, and from thence into _Britain_, every one may easily conjecture, how much Alteration it must undergo in such a Travel, from a hot and dry Climate into a moist and cold one, not so much in its own Nature, as from the Vehicle of Air which conveyed it, and thereby producing different Degrees of Infection, and Series of Symptoms: But this Variation would be most discernable in the Complication of the pestilential _Seminium_, with the particular Diseases of each Country, and those which are as it were peculiar to them: This in our Case is very well worth Notice, for in _Holland_, where the Scurvy extreamly reigns, and therefore, for Reasons before given, most liable to a pestilential Infection, it obtained only as a more aggravated Scurvy, as shall hereafter be further remarked.

AS for that Opinion of the famous _Kircher_, about animated Worms, I must confess I never could come at any such Discovery with the Help of the best Glasses, nor ever found the same discovered by any other; but perhaps in our cloudy Island we are not so sharp-sighted as in the serene Air of _Italy_; and with Submission to so great a Name, it seems to me very disconsonant to Reason, that such a pestilential _Seminium_, which is both of a nitrous and poisonous Nature, should produce a living Creature.

AS in putrid Fevers, so in a Pestilence, Malignity is a Destroyer of Insects, and frightens them away as it were alive, so far is it from giving Birth to them; indeed in some malignant Ulcers and Cancers, and in the Blood of some People, sometimes _animalcula_ are found; which is rather to be looked upon as the Effect of some Fault in the nutritious Juice, than the Produce of any Poison; and therefore they are not to be accounted amongst the Causes of a Pestilence.

SECTION III.

_Of the primary Seat of a Pestilence; where, by the Way, is considered the Nature of the Spirits, and their Infection in an humane Body from Poison._

IN Order to put an End to the Controversies about the Seat of a Pestilence, which have from Antiquity even to this Day been warmly maintained, many Authors putting the Heart for the Principle of Life and Death, some the Brain, and others the Stomach, Lungs, or Liver: It will be necessary here to discover the immediate Residence of the pestilential _Seminium_. Since therefore the above-mentioned _Aura_, according to Hypothesis, is very subtile and spirituous, for that Reason there must necessarily be some conformable Property in the Matter which is fit to receive it; as therefore there is not in the whole humane Machine any Subject more apposite, and capable of its Union, than the animal Spirits, we must fix its Residence there. But because I am sensible what Objections this Opinion lies open to, with some Persons, who may not conceive how an immediate Infection of the Spirits is communicable to the Viscera, and all Parts of the Body, it will be necessary to go thro’ this Matter in a very particular Manner, by enquiring;

_FIRST_, What are the Spirits concerning which we are here speaking?

_SECONDLY_, What is that Disposition of Spirits which makes them fit to receive the pestilential Impression? And,

_THIRDLY_, After what Manner the vitiated Spirits can affect the whole Body with Disorders?

TO this Purpose we must know, that the Spirits are the most thin and subtile Particles of the Aliment and other Juices, raised to the utmost Perfection and Volatility by the innate Heat, and the nitro-aerial Spirit, to serve in the Operations of the Mind, and all the Purposes of the animal OEconomy.

THE Matter whence the Spirits are generated is the Chyle, and their Restauration, Confirmation, and Vigour, from the Recruits of Food, as is their Languor, Prostration, and utter Extinction from the Want of it; so that howsoever they were first generated in the original, they owe their Conservation and Vitality to the Nourishment continually brought in; and although in a State of perfect Health _they_ are never changed by _that_, yet they continually act upon that after various Ways, bringing it from a crude, recrementicious State, into a noble Juice, or rich spiritual Balsam, retaining its ideal Character: And hence it comes about, that although there is a daily Waste of Spirits, there is no Want, because Nature is continually, while Things are in Health, making more; insomuch that after a due Constitution of Spirits is obtained, they of themselves are the main Efficients in making more, as one Light is kindled by another, and as the Blood it self is the chief Instrument in Sanguification, or making more Blood.

IT is a Matter indeed of much more Difficulty to determine, how Particles from a gross Origin, should be raised to so great Volatility and Fineness; but this is very certain, that when they are elaborated in the most perfect Manner, they exceed even the Light and Activity of the Sun-Beams; and the brighter and more active they are, the better do they perform their Offices in the OEconomy, as from their Efficiency is procured a State of Health and Vigour both in Body and Mind.

IT is of no great Moment to enquire, what Quantity of Spirit is necessary for the Conservation and Support of an humane Body, so that we do but know they partake of the Source from whence they are generated, insomuch that they are more or less perfect, according to the greater or lesser Degree of Purity in their productive Juices.

BUT I must here acknowledge my self diffident in that Opinion of the Spirits being prepared of a different Nature for particular Parts, for according to the Influences of the Mind, and the Contiguity, Rectitude, or Consent of the Vessels, they are by a voluntary Act determined the same into this or that Limb or Part: Which is manifest enough in the Prick of a Needle, or a venomous Bite, from the great Affluence of Spirits to that Part; I have therefore no Notion of a continued Emanation of Spirits, but that on such Occasions they are called, by the Sensation upon the affected Part, from the nervous Origin where they are elaborated.

_SECONDLY_, It sometimes happens that the Spirits degenerate from their native Purity, as also at others that they prove abortive, in not arriving to their utmost Maturity, whereby they lie more open to foreign Impressions of Distemperature.

BUT when the juices, or common Promptuary from whence the Spirits are generated, is not uniform, genuine, and perfect in kind, it is impossible that Spirits should be made from it in any tolerable Perfection; for one may as well pretend to wash a Brick, or draw clear Water from a foul Spring, as expect pure and natural Spirits from a corrupt and vitiated Chyle; although even when the Chyle is in right Order, there may various Errors happen in the Generation of Spirits, as from too great an Heat agitating the Blood in a preternatural Manner, or from an imperfect or unequal Separation of Particles, or from too much Cold causing an Intermixture of Crudities; and again, although the Spirits are duly elaborated, yet they may run into irregular Motions, and be the Occasion of many Disorders: But what is most to the Purpose, they may sometimes also receive a Taint from external Impressions.

AND this Aptitude, or Propensity of the Spirits to receive a pestilential Taint, is manifest from their fiery, or rather saline Nature, for on Account of that Subtilty which they acquire thereby, do they more naturally attract the contagious _Aura_, than Bodies more gross and heavy: For as these Spirits, as before observed, are nitrous, and inflammable, by their Similitude to a pestilential _Aura_, they not only are fitted to receive, but even attract it, and provoke it into Union; as the Snuff of a Candle just blown out, if it is not too far off, will by an Affinity of Qualities be soon rekindled by another lighted one at some Distance; and how much soever the poisonous Qualities of the pestilential _Effluvia_ may be destructive of the animal Spirits, yet there is nothing more certain, than that their Taint is very easily impressed upon them.

AFTER the pestilential Poison is thus received by the Spirits, it is impossible to express the fatal Consequences, and the cruel Havock that is made in the whole OEconomy; for the same Instruments which before were aery, lucid, and like the Rays of the Sun, immediately become vapid, dark, and useless, neither able to invigorate the Constitution, nor defend it against the Contagion.

_THIRDLY_, Having briefly passed over these Matters, it remains that we shew by what Steps the humane Frame comes to be disordered by this pestilential Invasion; and in Order to this, I know not a more fatal Circumstance in Nature than to have the very Guards and tutelary Preservers of Life, turn, as it were, Deserters and Betrayers. For there is nothing more manifest, than that the whole Compage, and its several Parts, run into Decay as soon as the pestilential Taint takes Place; for immediately upon the first Seizure, the whole Effort of Nature, as at _Rome_ when _Hannibal_ was at their Gates, is recollected against the Enemy, as sensible that all is at Stake, but being unequal to the Conflict, they retreat, and are taken Prisoners, leaving the whole Body defenceless. Hence the Infection runs through all the Blood, whereby the Heart and Lungs are principal Sufferers. Hence such a Corruption of the nutritive Fluids, that the whole nervous System is disturbed, the burning Heat of the _Pancreas_ produces the most extream Sickness, and hence follows such a Depravation of the whole Machine, that all the vital Faculties cease to act, and Death closes the fatal Scene.

BUT I do not at all see how such a noble Part as the Heart, should be first affected by any particular specifick Quality in the Poison of a Plague, to affect that more than any other; as if it was so frightful, as some would have it, to attack the Principles of Life at once; for the Heart seems at first to be affected chiefly from the Multiplicity of Vessels, and the great Crowd of Circulation that Way, giving Opportunity for the Venom sooner to arrive thither; concerning which we shall have Occasion to say more under that Head of Symptoms.

UPON the strong, presumptive Proofs therefore that the pestilential Poison chiefly resides in the Spirits, we cannot but much admire at the Weakness of those, who expect to detect its Nature and Cause from what they can find on the Dissection of morbid Bodies, and such like Circumstances: For a very noted Person, and one of exquisite Skill in Anatomy, although he himself at last fell in the general Calamity, affirmed, that the Seat of the last Pestilence was in the extream Angles of the _Plexus Choroides_, towards the _Cerebellum_, because he had found a small Vesicle there; others have observed the Lungs to have been marked with the Tokens of Infection; others report the Heart to have been tumefied, and burnt as it were, to a Coal; whereas it is plain, that these Parts are only so many Fields of Battle, where the Spirits and the Infection contend it with each other; Nor will any one, who rightly considers these Things, wonder, that such Marks of Devastation should every where be left by so cruel an Enemy.

THEREFORE, although it should be granted that the most obvious and open Tokens of a Pestilence are from a spiritual and an invisible Cause, and whose Effects may perhaps sometimes be laid open to Sight, yet I have no Intention to discourage anatomical Dissections as a needless Trouble, for by such Light, Medicine is recovered from the Reproach of Conjecture; but when Bodies are opened which have been destroyed by such subtile Agents as here spoke of, there is no Confidence to be given from thence to the Nature of the Disease; and those who have been most knowing in the Nature, Use, and Disorders of the Spirits, very well can direct how to recover those Disorders, and avoid future Inconveniencies by immediate Application thereunto.

AND Lastly, to conclude this Doctrine concerning the Spirits Infection, this irrefragable Argument may be produced from the Intention of Cure; for I have experienced by more than a thousand Instances, that the more cardiack and alexipharmick Medicines are subtile and spirituous, the more certainly do they encounter the pestilential Poison with Success; whereas, on the contrary, those Medicines which are coarser and slower of Exertion, do little or no Good. But this we refer to the curative Part hereafter in another Section.

SECTION IV.

_Of the Complication of a Pestilence with other Distempers, and particularly with the Scurvy._

AS the Pestilence is the most powerful of all other Distempers, so it also claims a particular Privilege of joining with all others; so that it does not more excel in its own Contrariety and Antipathy to Nature, than it asserts a Prerogative over all those various Evils which the humane Frame is subjected to, and draws them into its Assistance in exercising its cruel Power over Mankind.

THIS Assertion might be supported by a Multitude of Instances, if it were not for taking up too much of the Reader’s Time; for which Reason we shall only take Notice, that amongst all those Distempers which are thus inclined to join their Forces with this most powerful Enemy, some seem to have a more particular Fitness for such a Union, from a common Affinity in the Nature of their Infection, and the Energy of their Poison.

ONE of the First of this Class is the venereal Disease, with which the pestilential Venom does in a very familiar Manner unite it self. At the first breaking out indeed of the last Sickness it was given out by common Fame, that those who were previously infected with any foul Distemper, as the Pox in particular, would be secured thereby against the pestilential Taint; but wicked and impious was the Consequence of such a Suggestion; for many were hereby encouraged to seek the most lascivious and filthy Prostitutions, on purpose to be secur’d by one previous Infection against another: But besides the poisonous Quality peculiar to this nasty Disease, besides that Expence of Spirit in the procuring it, and besides a lost Force of the Constitution thereby, the greatest Aggravation to this Misfortune was, that the very Taint which was to defend against another, had it in its Nature to be more forcibly attracted by it; so that the rash Adventurer was soon brought to a bitter Repentance for his Experiment, by sinking immediately under the pestilential Contagion at its first Stroke; and it was common to find, by a very easy Transition, the venereal Buboes changed into pestilential Carbuncles, except in a few Instances where Nature found out an uncommon Artifice against these united Powers, by endeavouring an Ejectment of their joint Malignities by Salivation, whereby sometimes the Patient was brought into some Chance for his Life, both the Poisons being in a great Measure cast off together that way.

BUT here it may not be improper to admonish the young Physicians not to be too forward Imitators of Nature in such a Circumstance; unless they will run the same Hazard with a certain Empirick, who crouded his Powders upon the Sick that raised an untimely spitting, and brought a great many into a dangerous Condition, which by a regular Practice might have been, tho’ with Difficulty, saved.

Yet to set this whole Affair in a clear Light, there is great Reason to suspect that in many Cases Mercury had for some time remained in the Body, which, like a Snake in the Grass, being raised by the Pestilential Infection, flew up into a Salivation; for the febrile Heat, assisted with Medicines also of an hot Nature, throw up the Mercury, which had long lain quiet, like a Sublimation; which should be a Caution, not only to young Physicians, but those of more standing in Practice, not to be so buisy with mercurial Medicines, to Children as well as grown Persons, as they are too much apt to be; least besides the Inconveniencies already mentioned they cause malignant Ulcers, and Rotenness upon the Bones, as it is too commonly observed to be done in irregular Practice, to the irreparable Detriment of the Patients.

I am not however ignorant that sometimes the Pestilential Venom may tumifie the salival Glands without any other Assistance, and occasion Ulcers in the Mouth as with Mercury; for it is a common Case in many malignant Fevers.

BUT it is so clear a Matter that the Pestilential and venereal Poysons may intimately join together by their Affinity with one another, to the great Detriment of Mankind, as to want no further Proofs to confirm it; nor does their Opinion at all obviate ours, who place the venereal Poyson in Humidity, and that of a Pestilence in Dryness, as long as the Symptoms and Affections of both discover one common Principle, that is, somewhat saline; but yet if this should not be granted, they are naturally enough joined together by their known Malignity and Destruction to human Nature.

BUT the Affinity between a Pestilence and a Scurvy is not a slight, and a supposititious Conjecture, but strengthened and confirmed by a plain Union between them, whereby they attack like confederate Troops; and both confess the same Origin, _viz._ a saline Principle; as is most remarkably obvious in their eager Coalition, whether we consider the forementioned Transplantation of the like Plague from _Turky_ to _Holland_, where their Alliance was first formed; Or whether we reflect upon them both as Distempers equally epidemical, which when joined make such cruel Havock among the human Species; as neighbouring Flames catch together from a like Affinity of Parts, and burn with united Fury.

FOR although there is a great Difference in Salts of different Kinds, yet there is a common Property amongst them all, that when joined together they cannot hardly by any Means possibly be afterwards separated, for which Reason when these two Enemies of Mankind were joined, the complicated Evil was at first customarily distinguished by the _outlandish Scurvy_, which by a confederate Power had increased its Malignity to so great a Degree. But to give some apparent Facts, which irrefragably prove the natural Union between these two Origins of Mischief, it may be proper to recite some Symptoms common to them both, and first of all those Spots which were their certain Characteristicks.

THE Spots of those in the Plague were sometimes so numerous, as to cover all the Body, of which we shall say more hereafter; and if we consider the Appearances and Conditions of the Spots in both, we shall find a very great Agreement; the pestilential Spots sometimes break out broad, at other Times more contracted, just in the same Manner as it happens in a Scurvy; and as to their Duration, sometimes they are longer out than at others in both; now also suddenly appear, and then again as suddenly turn in, and sometimes remain out for two or three Days together; and their Likeness in all Respects is frequently so great, that amongst the ignorant Nurses and Empiricks, sometimes the fatal Tokens of a Pestilence have been mistaken only for Scurvy Spots: As to their Colour in a Plague, as well as in a Scurvy, they are sometimes florid, resembling fresh Flea-Bites, and at others dusky and livid; and I met with them in a certain Youth resembling Violet Flowers painted all over the Body; and in some I have seen them almost quite black, which are with great Difficulty to be distinguished from the true pestilential Tokens.