Gout, with a section on ocular disease in the gouty

The Antiquity of Gout. Prevalence of Gout in the Anglo-Saxon Period. Views of the Humoralist. The Aphorisms of Hippocrates. Introduction of the Word Gout. Early Views as to the...

Definition. Classification. Suggested Classification of Articular Gout. Etiology and Morbid Anatomy. Bodily Conformation and Individual Temperament. Locality, Race, Climate. Foo...

Revelations of the Bio-chemist. The Formation of Urea. Fate of the Amino-acids. Seat of Formation of Urea. Amino-acids in Relation to Gout. The Glycocoll Theory of Gout. Urea Ex...

The Isolation of Nucleic Acid. Researches on Spermatozoa. The Discovery of Purins. Uric Acid a Derivative of Nucleic Acid. The Chemistry of Uric Acid and the Purin Bodies. Chemi...

Exogenous Purins. Exogenous Uric Acid Excretion. Fate of the Unexcreted Purins. Endogenous Purins. Source of Endogenous Purins. Proteins and their Derivatives. Amino-acids and D...

Uric Acid Excretion in Gout. Uric Acid Variations in Acute Gout. Uric Acid Variations in Chronic Gout. Retarded Exogenous Uric Acid Output. Lowered Endogenous Uric Acid Output....

Anomalies in Uric Acid Excretion in Gout. Uricæmia in Nephritis. The Relationship, if any, between the Amounts of Uric Acid and of Urea, and Total Non-protein Nitrogen in Human...

Folin and Denis’s Method. Uric Acid a Normal Constituent of Blood. Effect of Exogenous Purins. Uric Acid Content of Blood in Gout. Hyperuricæmia in Non-gouty Arthritis. Variatio...

Constitution of Tophi. Mode of Formation. Localisation of Uratic Deposits. The Causation of Tophi. Solubilities of Uric Acid. Tophi in Relation to Uricæmia. Tissue Affinities fo...

Boerhaave’s Forecast of the Infective Theory. Ringrose Gore on Infective Origin. Leucocytosis in Acute Gouty Polyarthritis. Chalmers Watson’s Researches on Gout in a Fowl. Traut...

Analysis of the Acute Paroxysm. The Evolution and Life History of Gout. Analogies between Gout and the Specific Infective Arthritides. Correlation of the Metabolic Phenomena of...

Acute Localised Gout. Prodromal Symptoms. Dyspepsia. Premonitory Symptoms of Tophus Formation. Premonitory Articular Pains. The Acute Paroxysm. Detailed Consideration of Phenome...

Acute Gouty Polyarthritis. Mode of Invasion. Distribution of Lesions. Local Characters. Constitutional Symptoms. Changes in the Blood. Leucocytosis. Collateral Phenomena of Gout...

Chronic Articular Gout. The Joint Deformities of Chronic Gout. Tophi: Their Evolution and Distribution. Other Sites of Tophi. Affinities between Gout and other Diseases. Gout in...

Articular Gout. Etiological Diagnosis. Clinical Diagnosis. Introductory Remarks. The Diagnostic Status of Tophi. Tophi in Relation to Arthritis. Frequency of Tophi in True Gouty...

Acute Articular Gout. Localised Variety. Differential Diagnosis. Infections. Acute Gonococcal Arthritis. Traumatic Lesions. Acute Osteoarthritis. Static Foot Deformities. Hallux...

Acute Gouty Polyarthritis. Differential Diagnosis. Acute Articular Rheumatism. Acute Gonococcal Arthritis. Etiology. Onset. General Symptoms. Distribution of Lesions. Local Char...

Chronic Articular Gout. Chronic Monarticular Gout. Monarticular Gout in Large Articulation a Rarity. Chronic Gout of Oligo-articular Distribution. Its Confusion with Chronic Vil...

Evidence of Gout in the Eye. Deposition of Urates. Gouty Diathesis. Significance and Location of Tophi. Relative Incidence of Iritis. Metastasis. Arthritic Iritis. Gouty Iritis...

Radical Treatment of Local Foci of Infection or Toxic Absorption. Diet in Acute and Chronic Gout. The Fallacy of Fixed Dietaries. Thorough Physical Examination a necessary Prelu...

Initial Purgation. Colchicum in Acute Gout. Method of Administration. Preparations and Dosage. Colchicine, Salicylate of Colchicine. Atophan. Alternative Remedies in Acute Gout....

Alkalies. Contrasts between Salts of Sodium and Potash. Differential Indications for their Usage. Alternatives. Salicylates. Benzoates. Hexamine. Iodides. Iodine. Albumen Compou...

Climate. Choice of Residence. Clothing. Exercise. Massage. General Hydro-therapy. Importance of thorough Physical Examination. Individual Reactive Peculiarities. Prophylactic Me...

Difficulties of Definition and Classification. Radio-activity. General Principles of Spa Treatment. Physiological Action of Radium Emanation. Activation of Body Ferments. Influe...

“Teeth, bones, and hair,” quoth the Sage of Norwich, “give the most lasting defiance to corruption,” and were it not that “Time which antiquates antiquities and hath an art to m...

Under the vague term “articulorum passio” or “arthritis” the physicians of antiquity handed down to posterity the clinical description of a disease in the varied symptomatology...

The fanciful views of the humoralists as to the etiology of gout exercised almost undisputed sway up to the latter half of the eighteenth century. At that time the great Scottis...

Said Locke long since, “There are some words which will not be defined,” and surely of these is gout; for reflection upon the proffered definitions thereof is apt to leave one w...

Not only is the proximate cause of gout unknown, but the essential nature of the disease is still shrouded in obscurity; for the obliquity in trend of protein metabolism, manife...

No hard and fast line can be drawn between the metabolism of protein and that of nuclein. For though, morphologically speaking, the _nuclei_ of cells are sharply differentiated...

Uric acid, like the “purin bodies” (xanthine, hypoxanthine, guanine, and adenine), is derived from _nucleins_, _i.e._, from the breaking down of tissues rich in cells. The end-p...

The chemical structure and sources of uric acid having been dealt with, we are now in a position to resume our narrative, and to take up the thread at the point when Horbaczewsk...

It will be recalled that at the close of our chapter on Pathogenesis we referred to the growing scepticism of Garrod’s views as to the pathogeny of gout. Still, if we except Edw...

This time-worn hypothesis as to the pathogeny of gout has, perhaps, provoked more controversy than any other etiological problem in the sphere of clinical medicine. Nor, unfortu...

In the summer of 1848, Garrod made his momentous announcement that “the blood in gout always contains uric acid in the form of urate of soda, which salt can be obtained from it...

Hyper-uricæmia and uratosis, though they both occur in gout, are by no means of identical pathological valency or significance. In hyper-uricæmia the uric acid, either in a free...

With the abandonment of the uric acid theory of the causation of gout we see a reversion, curiously enough, to the hypothesis held by the ancient physicians as to its pathogeny....

“The old order changeth, giving place to new,” and the uric acid theory having failed us, it is essential that we cast round for some other solution of the problem, carrying wit...

If we reflect on the general features and local characters of an initial outbreak of gout they are precisely such as would, did they occur anywhere but at the classic site, _the...

If we would clarify somewhat the obscurity that enshrouds the genesis of disease, our watchword must here, as in other spheres, be “Despise not the day of small things.” We know...

While gout may throughout its life history confine its ravages to the _foot_, if not solely to the _toe joints_, it may, even in the _initial_ attack, involve many articulations...

In delineating the features of the _acute polyarticular_ variety, we have to a certain extent trenched on the clinical territory of the _chronic_ form; this is scarcely avoidabl...

The intimate cause of gout is unknown—a humiliating reflection, albeit salutary, if it but engender a more catholic attitude on our part when seeking to unravel the nature of th...

The nonchalance with which not a few writers dismiss the diagnosis of _acute gout_ when located in the _great toe_ or elsewhere in the foot is, to say the least of it, somewhat...

In the pathways of medicine, as in other walks in life, we are apt to become stereotyped, to fall into grooves, and sooner or later the inevitable rude awakening comes. Thus, so...

If the diagnosis of acute types of articular gout often presents difficulties, these same are, if anything, accentuated when we approach its chronic manifestations. For, _apart...

As an aid to the differentiation of _gouty_ from _non-gouty_ forms of _arthritis_ skiagraphy has scarcely fulfilled the somewhat optimistic claims at one time made on its behalf...

Nevertheless one approaches with diffidence this debatable ground, so hedged in by high sanction and tradition. Albeit reverence for authority must, in the interests of progress...

With the passing of Jonathan Hutchinson disappeared the premier British exponent of _l’arthritisme_, that generic term so attractive to our French _confrères_. Whether gout and...

Adaptation is the keynote to progress in therapy—adaptation of our therapeutic measures to the ceaseless advances of pathology. In the history of gout it has ever been so, the c...

The victim of gout is easier led than driven. Show no “bowels of compassion” for his failings, talk to him in the spirit of a dehumanised disciplinarian, and your tenure of his...

The illustrious Sydenham, for more than thirty years a sufferer from gout, was clearly in doubt as to whether a cure of the malady was to be attempted or even desired. It was Na...

Despite the fact that _heredity_ plays so dominant a _rôle_ in the genesis of gout, how relatively scanty the attention paid to _prophylactic_ measures! It is the _second_, neve...

The gastric derangements that precede acute gout nearly always become aggravated when the disease is permanently established. Consequently from time to time many of the measures...

While, naturally, individuals display wide differences in their capacity of adjustment to variations in climate and season, there is no doubt that the gouty, as a class, are abn...

Though many have tried, no one has yet been able to define exactly what does and what does not constitute a “mineral water.” Criterion after criterion has been suggested—chemica...