Part 5

_Second day._—Restless sleep as the first night. Wakes several times at night, always preoccupied with the idea of quarrelling with somebody who frightened him. The dulness continues. 30. Weight at the forehead. Tight feeling at the inner side of the right leg, with red spots. Appearance like incipient erysipelas. Shuddering with twitching. Yawning. 35. Intermitting pain in the right groin after walking. Taste of doughy bread in the mouth. The sight is very sensitive to light, he cannot open his eyes in a spot which is illumined by the sun. At eight o’clock in the evening, pain in the right groin as if pricked with a pin, in the direction of the joint, for a quarter of an hour. The same pain is felt in the navel in a recumbent posture.

_Third day._—40. Numbness of the arm on which he had been lying at night. Hardness of the left leg, with lancinations. Mottled appearance of the face. Red and humid spots on the left leg. Quiet and short sleep, he wakes four times at night. 45. Dulness of the head; same weight at the forehead. Heat in the right leg, where the red spot is; this is sensitive to contact. Taste as of doughy bread in the mouth. Depression of spirits in the day-time. Erection in the evening, with desire to lie down.

_Fourth day._—50. Numbness of the hands and legs. Uneasiness in the left leg.

ARRANGEMENT ACCORDING TO HAHNEMANN.

HEAD, &c.: 1. Depression of spirits. Weight at forehead. The head feels heavy and dull. Heat in the head. 5. The head feels compressed as by a band tied behind. Sensitiveness to light. Left side of the tongue feels sore. Taste of doughy bread. Copper taste in mouth, with heat in throat. 10. Mottled appearance of the face. Hot face. Pricking at right nasal wing. Pain in right groin after walking. Pricking pain in the right groin and navel. 15. Slight pain around the navel. Diarrhœa. Erection.

EXTREMITIES, &c.: Numbness of the arm on which he had been lying. The left leg feels weak. 20. Tight feeling at inside of right leg, with red spots. Hardness of the left leg, with lancinations. Heat at the legs. Heat in the right leg, where the red spot is. Bruising sensation in left toes. 25. Uneasiness in left leg. Restless sleep. Yawning. Quiet sleep, with frequent waking. Dreams about men dressed in black, about imprisonment, &c. 30. Yawning. Shuddering with twitching. Sensation of goose-flesh. Cold feeling. He feels weary and sore. 35. Languor. Numbness of the hands and legs. Incipient erysipelas. Callosity above the left inner ankle. Red and humid spots on left leg. 40. Dark-red inflamed spots in face, right side.

GUANO AUSTRALIS.

This substance, which has been used for some years past as manure, is found on the coasts of Patagonia—and principally on the Lobos Island near the coast of Peru. We have proved the different varieties of guano, and likewise the crystalline particles formed by the condensation of ammonical vapors which rise from the guano in abundance. Our hope to discover in these crystals a more active normal agent, has not been realized, so that, in the end, we have found the freshest possible guano preferable for medicinal purposes. It is triturated in the same way as all other substances.

_First day._—1. Internal shuddering for three minutes in the morning. Violent headache. Pain in the forehead when inclining the head forward, at 6 o’clock in the morning. Violent itching at the back, and painful smarting after scratching, at 7 o’clock in the morning. 5. Formication in the right nasal fossa, at 7 and a half o’clock. Pain with pinching behind the ears, at 8 o’clock in the morning. Dizziness, objects turn from below upward, at 9 o’clock in the morning. Nausea with profuse flow of saliva. Pale face with faint feeling, at noon. 10. Lassitude, at half past two in the afternoon. Desire to vomit, at half past two in the afternoon. While eating, pain at the pit of the stomach and desire to vomit. Profuse sweat all over, after eating. Aching in the forehead and temples, worse when stooping, at half past three. 15. Pain at the styloid process of the left wrist. Pain in the lungs which stops the breathing, for three minutes. Swelling of the right index-finger. Itching of the genital organs. Water feels extremely cold to the hands, they feel like ice when keeping them in the water a little longer. 20. Pain at the feet which prevents one from pressing them to the ground, at 5 o’clock in the evening. Red spot, with itching at the back, and smarting pain after scratching. Violent headache as if the head were incased in iron.

_Second day._—Beating at the left commissure of the lips, at 6 o’clock in the morning. Itching in the right nostril and frequent sneezing, for one hour, at half past 6 o’clock. 25. Great weakness. She remains at the spot where she happened to have located herself.

_Third day._—Painful ganglion on the left arm, with redness and itching; when scratching the arm, it remains insensible until the skin was off; lasts for half an hour, at 6 o’clock in the morning. Headache: he feels as if the head were opened, at 8 o’clock in the morning. Smarting ganglion below the right calf, hindering walking, and lasting until night.

_Fourth day._—30. Nausea, one cannot bear seeing persons eat, at 7 o’clock in the morning. Painful ganglion at the left elbow. Small itching pimples. Violent beating of the heart; feeble breathing, for five minutes. Large hard and red place on the back, with pricklings as from a thousand pins. This sensation commences at 9 o’clock and lasts all night.

_Fifth day._—35. Profuse sweat on the arms and hands; the skin on the thighs is insensible; a prick is not felt; for two days they are covered with little pimples. Cramp at the pit of the stomach before eating.

_Sixth day._—Violent pain at the right knee, as though pieces of flesh would be torn from him, at 7 o’clock in the morning. Burning under the soles of the feet, she cannot keep her shoes on. Cramp at the left thumb, for an instant.

_Seventh day._—40. Sensation as if the gums were cut with penknives, after which they bleed for half on hour, at 6 o’clock in the morning. Formication in the right nostril, for five minutes, at 10 o’clock. Sensation of hammering in the nape of the neck, at 3 o’clock in the afternoon. Pain in the abdomen as if pierced by sharp points, at 9 o’clock in the evening.

_Eighth day._—Tongue white and thickly coated. 45. Bitter bilious taste in the mouth, at 6 o’clock in the morning. Deep sleep. She dreams that she is playing with wild beasts.

ARRANGEMENT ACCORDING TO HAHNEMANN.

HEAD, &c.: 1. Dizziness, objects turn from below upward. Headache. Headache as if the head were encased in iron. Headache as if the head would split. 5. Aching pain in forehead and temples. Pain in forehead when inclining the head forward. Pale face, with faint feeling. Pinching pain behind the ears. Cutting in the gums, followed by bleeding. 10. Tongue coated white. Beating at the left commissure of the lips. Formication in right nasal fossa. Itching in right nostril, with sneezing.

GASTRIC, &c.: Bilious taste in mouth. 15. Cramp at pit of stomach before eating. Nausea, cannot bear seeing people eat. Pain at pit of stomach, with desire to vomit, while eating. Sweat all over, after eating. Nausea, with flow of saliva. 20. Desire to vomit. Sharp piercing-sticking pain in abdomen. Itching of the genital organs. Palpitation of the heart. Pain in the lungs, arresting the breathing.

EXTREMITIES, &c.: 25. Hammering sensation in nape of neck. Itching of the back, with smarting after scratching. The hands feel like ice in cold water. Pain at the left wrist. Swelling of the right index-finger. 30. Cramp at the left thumb. Burning at the soles. Pain at the feet when pressing them to the ground. Pain at right knee, as if the flesh would be torn off. Internal shuddering, in the morning. 35. She dreams that she is playing wild beasts. Itching, red spot on the back. Hard and red spot on the back, with pricklings. Smarting ganglion below the right calf. Painful ganglion on left arm, with redness. 40. Weakness, no desire to stir. Lassitude. Profuse sweat on the arms and hands, with insensibility of the skin and little pimples.

HIPPOMANE MANCINELLA. (L.)

HIPP. MANCINELLA VENENATA, TUSS.

Although the poisonous properties of the mancinella have been very much exaggerated, it is nevertheless a very poisonous tree, which, happily, becomes more and more rare, owing to its being rooted up with great care wherever it shows itself. It is a tree from 12 to 15 feet high, with a trunk having a white and soft wood and covered with a greyish bark. Its branchy top gives it the appearance of a European fruit-tree. Its leaves are alternate, oval-acute, somewhat cordate at their base, with fine indentations, and a red gland at their apex. They are attached to long petioles; stipulate while young. Flowers monoïchous, forming long terminal spikes, the male flowers being above, the female below or at the axilla of the leaves. The male flowers have a bifid perianth whence emanate the stamens, the united filaments of which form a column that supports the anthers. The female flowers have a perianth with two or three divisions and a rudimentary foliole; the ovary is round and superior; style straight, terminating in 6 or 7 red, radiating, reflexed stigmata. The fruit is round, pulpy, from 5 to 6 inches in diameter, umbilicate at the top, and inclosing a wooden kernel with seven monosperm compartments.

The fresh leaves are triturated. When we were informed that a mancinella had been discovered near Rio, we requested Mr. Ackermann, a pupil of the institute, to repair to the spot for the purpose of verifying the identity of the plant, and collecting its juice. Having accomplished his mission, he drunk a portion of the liquid, on the 10th of January, 1847, in a public sitting of the institute. He was joined in the proving by several of our pupils. Some of the following symptoms were so violent, that they had to be counteracted by antidotes. The pathogenesis of the mancinella is one of the most precious additions which our Brazilian provers have furnished to our Materia Medica.

Prover: M. E. T. Ackermann.

FIRST PROVING.

_First day._—1. Merry mood, desire to sing. Is disposed to take every thing in good part. Buzzing in the ears and whizzing like the wind, when walking. Urine scanty and whitish. 5. Sensation of heat and trembling in the chest. Constant eructations like volumes of air. Watery vomiting. Violent pain in the abdomen, as if he had been struck by the point of a stick.

_Second day._—10. Heavy sleep, and late waking. Evanescent ideas. Sensation of paralysis immediately after rising, his hand trembles a good deal; he is unable to open the door of his room. Absence of thought. Disposed to be silent. Deep tranquillity of mind, in the morning. 15. Sadness. Drowsy after breakfast. Embarrassed breathing when falling asleep again. Redness of the skin. Sweat in the palm of the hands whereas the rest of the body is perfectly dry. 20. Pain at the lower part of the head, and weight as if he had knocked it against any thing. Small pimples. Beating pain at the left side of the neck. Pain all around the neck like beats with a hammer. Pain at the right side of the head while hearing the strokes on an anvil, he felt as though he were struck with a hammer. 25. Pain at the nape of the neck and forehead when stooping; it is a dull, confused pain which he cannot describe. In the day-time the hands become red. Sense of weight over the eyes. His nose is looser than usual. Pain all round the head as from a blow after having remained in the sun for a time. 30. Redness and heat of the ears. Alternate hunger and loss of appetite. Weak stomach. Loathing. Profuse urine, but always a little white. 35. Acute pain with weight in the pit of the stomach, for a minute. Eructation during an expiration, like a volume of hot air, which ascends to the mouth with a feeling of oppression. Metallic taste in the mouth. White expectoration. Beating pain in the abdomen after breakfast. 40. Disagreeable sensation while hearing the noise of a saw. When hearing blows with a hammer the counter-shock is felt in the whole body. He alternately lays himself down and raises himself again. Swelling of the veins of the hands. Constant pain all day, in the wrist and metacarpus, as if strings were tied round very tightly. 45. Three slight beats on the arm, as if touched with the finger. Easy stool. The face is yellow and the body red. Copious emission of wind. Weak all over in the day-time. 50. Two attacks of colic and diarrhœa, with pulling and pinching in the bowels, at midnight.

_Third day._—Sad, then merry dreams. Every thing is unpleasant to him. The headache continues and renders him impatient. Feeling of tenderness and deep pity. 55. Profuse and whitish urine. The chest dilates a good deal, when drawing breath, even with the mouth closed. The chest feels bruised, with embarrassed respiration. The constrictive pain at the wrist shifts to the middle of the arm for an hour, after which it returns again to the wrist.

_Fourth day._—Lancinating pain in the left temple. 60. Buzzing in the ears, and drumming noise when walking against the wind. Lancinating pain in the chest. Prickings through the heart. The moral emotions are accompanied by an indescribable malaise, beating pain in the chest and loss of speech. When making the least exertion, he is attacked with violent cough and painful prickings in the throat. 65. When commencing to talk, a sudden suffocation and violent beatings in the chest. Suffocation and beatings in the chest when attempting to cough. Beating pain in the head and nape of the neck, with inability to bend the head forwards for the purpose of writing. Weak chest. Thirst every hour in the day-time; desire for water, with aversion to wine or any other liquor. 70. The weakness increases. Sadness. Colic and diarrhœa. Full and frequent inspirations. Urine clear and abundant, but whitish. 75. Lancinations in the bladder when commencing to urinate, he feels relieved after urinating. Pulling and dragging pain in the bowels.

_Fifth day._—Headache. Pain in the chest when making the least motion. The breathing is no longer embarrassed. 80. Extraordinary desire to smoke. Pricking in the feet when sitting. Weakness all over. Pain in the bends of the knees as if bruised. 85. Constriction round the thighs and legs as if a thread had been tied around. Lancinations in the groins. Sexual desire. Continual thirst in the day-time. Dry mouth. 90. Depression of spirits. Sadness. Cold extremities. Profuse and clear urine. Deep sleep in the day-time. 95. Aversion to work.

_Sixth day._—Dream about ghosts and phantoms. Headache. Sad in the morning. Increasing thirst in the day-time, until evening. 100. Heaviness all over. Profuse and clear urine. Loathing of every thing. Aversion to work. Desire to lie down.

_Seventh day._—105. Headache with vertigo, especially in the morning, after eating a piece of bread. Sensation as of a blow in the abdomen, followed by stool. Formication in the right hip, and lancinations when walking. Continual thirst. Sadness. 110. Clear and profuse urine.

_Eighth day._—The urine becomes natural again.

_Ninth day._—The previous symptoms disappear. Active mind, disposed to work. Good appetite.

_Eleventh day._—115. Tetter of an inch in diameter on the left arm; it disappears on the following day. Beating pain in the neck, abating for a few moments by reclining the head. Pricking in the mouth when eating bread. Desire to remain lying. Frequent stool. 120. Swelling of the left ankle. Pricking for two hours at the left knee-joint.

_Twelfth day._—Lancinating pain in the head. Heaviness at the head. Pain at the head after thinking, as from bandaging the head from temple to temple with the skin of a bladder. 125. Confused pain in the head when writing. Lancinating pain in the head, as soon as one sets about eating. Contusive pain at the clavicles, when turning the head right or left.

SECOND PROVING.

_First day._—(The drug was taken at half past seven in the evening.)

One hour after, violent headache, with painful lancinations. The pains continued all night, with sleeplessness.

_Second day._—130. The headache continues, especially at the temples and above the eyes. Acute pain at the elbow-joints. Taste of blood in the mouth. Rheumatic pain at the shoulder-blade. Repeated, violent lancinations in the right side of the abdomen. 135. Lancinations at irregular intervals, in the left shoulder-blade and muscles, from the left side of the chest. Headache all day. Constant dryness in the throat. Taste of blood in the mouth all day.

_Third day._—Painful lancinations in the head, temples, and over the eyes. 140. Intense lancinating pains in the left side. Lancinations in the hypochondria and shoulder-blades. The pain at the elbow-joint continues. Lancination in the right knee-joint. Excessive heaviness and dulness of the head. 145. Constant drowsiness. Incessant headache. Intense, lancinating and constrictive pain in the muscles of the upper part of the right arm, for more than an hour. Continued formication in both feet, especially the left. Taste of blood in the mouth, as if blood had ascended in the throat, and had left the taste of it in the mouth. 150. Frequent and violent lancinations in the abdomen and bowels. Almost complete loss of appetite. Comatose, constantly drowsy. The head feels very heavy, with constant pain in it.

_Fourth day._—No sleep at night. 155. The headache becomes intolerable. Taste of blood in the mouth. Attack of diarrhœa, with pain and tenesmus. First a natural stool, followed by frequent, painful discharges, first of black, fetid substances, then of a watery liquid; the attack lasts upwards of two hours. Lancination in the muscles of the right knee, also in the ribs and right side. 160. Pains in the hypochondria. Lancinating pain in the bowels. Lancinating pain in the left shoulder. The headache continues. Complete loss of appetite. 165. No sleep.

ARRANGEMENT ACCORDING TO HAHNEMANN.

1. MENTAL AND MORAL: Taciturn. Deep repose of mind. Evanescent ideas. Merry. 5. Sadness. Feeling of tenderness. Sad, then merry dreams.

HEAD: Heaviness and dulness of the head. Lancinating pain in the head. 10. Pain at the head, as if bandaged all round, after thinking. Headache with vertigo, after eating bread in the morning. Headache, especially in the temples, and above the eyes. Violent headache with painful lancinations. Pain as from a blow all round the head, when staying in the sun. Weight above the eyes. 15. Pain at nape of neck and forehead, when stooping. Pain and weight at lower part of the head. Lancinating pain in left temple.

FACE, GASTRIC: Face yellow, and body red. 20. Buzzing in the ears. Redness and heat of the ears. Buzzing and whizzing in the ears. Dry mouth. Loathing. 25. Loathing of every kind of food. Loss of appetite. Watery vomiting. Desire to smoke. Thirst every hour, with aversion to wine or liquor. 30. Alternate hunger, and loss of appetite. Pricking in the mouth when eating bread. Eructations, like volumes of air rising upwards. Hot air rises during an expiration. Taste of blood in the mouth. 35. Metallic taste in mouth. Dryness of the throat.

STOMACH, BOWELS: Weak stomach. Acute pain and weight in pit of stomach. Lancinations in the groins. 40. Pulling and dragging pain in the bowels. Sensation as of a blow in the abdomen, followed by stool. Violent lancinations in right side of abdomen. Pains in the hypochondria. Lancinations in abdomen and bowels. 45. Sticking pain in abdomen. Beating pain in abdomen, after breakfast. Flatulence.

STOOL, URINARY, GENITAL: Easy stool. Colic and diarrhœa, with pulling and pinching in the bowels. 50. Diarrhœa, with pain and tenesmus. Natural stool, followed by painful discharges, first of black and fetid, then of watery, liquid substances. Frequent stool. Dartings in the bladder, when commencing to urinate. Profuse urine, rather white. 55. Urine scanty and whitish.

CHEST: Full and frequent inspirations. Weak chest. Contusive pain at the clavicles when turning the head. Sense of heat and trembling in the chest. 60. Suffocation and beating in the chest, when attempting to talk or laugh. Violent cough and painful prickings in the throat, after the least exertion. The chest feels bruised, with oppressed breathing. Lancinating pain in the chest. Considerable dilatation of the chest, when drawing breath. 65. Embarrassed breathing. Prickings through the heart.

BACK, EXTREMITIES: Beating pain at left side of neck, or all around it. Pain at right side of neck as if struck with a hammer. Rheumatic pain at the shoulder-blade. 70. Dartings in the left shoulder-blade and muscles, from the left side of the chest. Beating pain in the neck, abating when reclining the head. Lancinating pain in the left shoulder. Intense darting and constrictive pain in the muscles of the upper part of the right arm. Tetter on left arm. 75. Slight beats on the arms as with a finger. Acute pain at the elbow-joints. Constrictive pain in wrist and metacarpus, all day, shifting to the arm. His hand trembles after rising, as if paralyzed. Sweat in the palm of the hand. 80. The veins of the hand are swollen. Formication in the right hip, and lancinations when walking. Constrictions around the thighs and legs. Bruising pain in the bends of the knees. Pricking at left knee-joint. 85. Dartings in the right knee joint. Swelling of the left ankle. Pricking in the feet when sitting. Formication in the feet.

SLEEP, &c.: Heavy sleep. 90. No sleep at night. Dream about ghosts and phantoms. Constant drowsiness. Deep sleep in the day-time. Red skin. 95. Pimples. Desire to lie down. Aversion to work. Indescribable malaise, with beating pain in the chest and loss of speech. Nervousness, the blows of a hammer produce a counter-shock in the whole body. 100. Beating pain in the head and nape of the neck, with inability to bend the head forwards. Cold extremities. Heaviness all over. Painful dartings in the head, temples, and above the eyes. Darting in the muscles of the right knee, ribs and right side. 105. Weakness in the day-time.

HURA BRAZILIENSIS. (WILLD.)

HURA.—ASSACÙ.—OASSACÙ.

This plant inhabits the equatorial regions of South-America, the provinces of Para, Rio-Negro, and the neighborhood of the Amazon, where it is very frequent. It resembles the hura crepitans; its leaves are alternate, somewhat cordate, rounded, glabrous, serrate; rolled up and stipulate while young. The petiole is provided at its top with two large glands. Flowers monoïchous; the male flowers having a short, urceolate perianth, and covered with a scaly bract; they form elongated, peduncled, terminal husks. The female flowers, which are twice as long as those of the hura crepitans, have their perianth resting against the ovary, which is surmounted by a long and infundibiliform style, terminated by a stellate stigma; they are solitary and placed near the male flowers. It is from this tree that the Indians draw the milky juice called Assacù by the Brazilians.

A man affected with lepra, and who had sought refuge in the solitary regions of the Amazone, took, by the advice of an Indian whom he met there, a considerable quantity of a juice known under the name of Assacù, flowing from the trunk of a tree, which has been described by Willdenow, under the name of hura braziliensis. He was cured; and the president of the province of Para, informed the imperial government of it. Since then, this juice has been very generally used by leprous patients without, however, curing them.