Part 10

Ointment of elemi was in all the London Pharmacopœias, and was only dropped from the B.P. 1898. In the earlier issues it was called “unguentum or linimentum Arcœi,” because it had been introduced and recommended by Arcœus of Amsterdam in 1574, for healing wounds. A similar ointment was called “Balsamum Arcœi” in the Prussian Pharmacopœia of 1847. The inventor’s formula was to melt together six parts each of gum elemi and turpentine, and add six parts of melted stag’s suet, and two parts of oil of St. John’s wort. Arcœus was a Spaniard by birth, and an eminent authority on the treatment of wounds.

FOWLER’S SOLUTION OF ARSENIC.

Thomas Fowler kept an apothecary’s shop in York from 1760 to 1774. In the latter year he relinquished trade, and went to Edinburgh to study medicine. Graduating as M.D. in 1778, he settled at Stafford, and was appointed physician to the Infirmary of that town. Later, he returned to York, where he acquired a large practice, and where he died in 1801.

It was in 1786, during his residence at Stafford, that Dr. Fowler published his treatise, entitled “Medical Reports of the Effects of Arsenic in the Cure of Agues, Remitting Fevers, and Periodic Headaches.” It was only a small work, but it made Fowler’s reputation, and introduced arsenic into the list of recognised remedies. The doctor stated that a certain Patent Ague Drops known as Tasteless Ague and Fever Drops, which had acquired some reputation in this country, had been occasionally tried in the Stafford Infirmary, and had been found efficacious. With the assistance of the apothecary to the Infirmary, a Mr. Hughes (“whose industry, attention, and abilities in his professional line justly merit applause”) he had ascertained that these drops were a preparation of arsenic, and he goes on to detail the experiments which led him and Mr. Hughes to devise the following formula as representative of the patent medicine:--

“Recipe arsenici albi in pulverem subtilissimum triti.

“Salis alkalini fixi vegetabilis purificati, singulorum grana sexaginta quatuor.

“Aquæ fontanæ destillatæ, libram dimidiam.

“Immitantur in Ampullam florentinam qua in Balneo Arenæ posita, Aqua lente ebulliat donec Arsenicum perfecte Solutum fierit. Deinde Solutioni frigidæ adde.

“Spiritus Lavendulæ compositum, unciam dimidiam.

“Aquæ fontanæ destillatæ, libram dimidiam, plus vel minus, adeo ut solutionis mensura libra una accurata fiat, vel potius Pondere unciæ quindecim cum dimidia.”

Fowler reminds his readers that of course troy weights are intended, and he explains that the spirit of lavender is added merely to give the mixture a medicinal appearance, lest patients entrusted to drop it for themselves might be tempted to use a water-white solution too freely. He also suggests that as arsenic conveys rather alarming ideas, this medicine should be described as “mineral solution.”

It is universally recognised that Fowler introduced the modern medicinal employment of arsenic, but it should in fairness be remembered that he was guided to his discovery by a quack remedy, as lie himself fully acknowledged.

The Liquor Arsenici Chloridi, P.L., was adopted from a formula of Dr. F. de Valangin, a Swiss doctor who qualified in England in 1765. He made a quantity and presented it to the Apothecaries’ Hall, where it was sold for some time under the name of Solvent Mineral.

FRIAR’S BALSAM.

Tinct. Benzoin Co., was a copy of Ward’s Balsam, which itself was only the adaptation of compounds which had been for a long time sold under the names of Friar’s Balsam, Commander’s Balsam, Jesuit’s Drops, Turlington’s Drops, and Traumatic Balsam. It was under the last name that it first appeared in the P.L. of 1746. This was only the Latinised name of Wound Balsam, another old designation of a similar preparation.

It is not known how the still popular name for this preparation, Friar’s Balsam, originated. It is included in the Schedule to the Medicine Stamp Act of 1812, suggesting that at that time it was regarded as a proprietary medicine.

A correspondent of _The Chemist and Druggist_ (P. F. R., April 15, 1885) quoted from the _Western Antiquary_, 1884, page 136, the curious item that a Portuguese merchant named Peter de Frias obtained from the Viceroy of Peru, about the year 1581, the fruit of a balm or balsam. It is not an impossible suggestion that Peter de Frias may have been the originator of our Friar’s Balsam. The substitution of benzoin for the balsam of Peru, which was probably the basis of his “wound balsam,” is easily accounted for. Perhaps a more likely explanation of the introduction of Friar’s Balsam into the Medicine Stamp Act is that there was a patent medicine “called the Frier’s Drops,” patented by Robert Grubb on June 13, 1777. It was intended for the cure of the venereal disease, scurvy, rheumatism, and other complaints. It contained calomel, antimony, guaiacum, and balsam of Peru in spirit.

The Baume de Commandeur, which was also called Baume du Commandeur de Permes, and Baume du Chevalier de Saint Victor, seems to have been the original of these benzoinated tinctures, and acquired considerable reputation in France. It was evidently at first a proprietary preparation, but Pomet in 1694 gave a formula for an imitation of it, with the remark that it would cure in eight days any wound by iron or fire, if it were not a mortal one. His formula prescribes benzoin, 3 oz.; dry Peruvian balsam, 1 oz.; storax, 2 oz.; Socotrine aloes, myrrh, olibanum, angelica root, and St. John’s wort flowers, of each ½ oz. digested in 2½ lb. of spirit, and strained. The Traumatic Balsam introduced into the P.L. substituted Balsam of Tolu for the Balsam of Peru, and omitted the myrrh, olibanum, angelica, and St. John’s wort. This was almost identical with the Tinct. Benzoin Co. of the present B.P.

The simple tincture of benzoin was already popular in this country when the Traumatic Balsam was introduced. It was taken in doses of 20 to 60 drops in asthma, but its more usual employment was as Lac Virginis (1 drachm of the tincture in 4 ounces of water) as an application for the skin.

GREGORY’S POWDER.

The original of the Pulv. Rhei Co. of the British Pharmacopœia was a prescription very frequently given by Dr. James Gregory, of Edinburgh, in his time the most famous physician of that city. He died in 1822. This Dr. Gregory was Professor of Medicine in Edinburgh University, as his father was before him. His son became Professor of Chemistry in the same university. Direct ancestors of these Gregorys had been professors of history, astronomy, and mathematics at Edinburgh, Oxford, and St. Andrews. Within a century and a half the family furnished sixteen professors to British universities, and it is a curious coincidence that the Church of Rome likewise counts sixteen Gregorys among its Popes.

It does not appear that the Gregory of powder fame ever published any special recommendation of his compound. He wrote a “Conspectus Medicinæ Theoreticæ” (1788) but the formula for his powder does not appear in that book. Annexed is a facsimile of one of Dr. Gregory’s prescriptions for his powder. He gave this prescription very frequently, but occasionally varied the proportion of the ingredients.

HIERA PICRA.

A medicine with this familiar name can be bought in any chemist’s shop in Europe or America to-day, just as it could in Damascus a thousand, or in Rome and Alexandria two thousand years ago. Probably it is the oldest pharmaceutical compound still in existence. Through all the centuries the hiera picra known to the public has been a preparation of aloes. The adjuncts have varied but aloes has always been the essential ingredient, with one celebrated exception.

The origin of this medicine is variously stated by medical historians. The common theory is that it first acquired fame as a remedy employed in one or other of the Æsculapian Temples. This may have been the case, but there is no evidence in support of the suggestion. It is possible that the name may have suggested the notion, and the drug vendors of Rome would certainly not discourage the fancy.

Before the time of Julius Cæsar there were no physicians in Rome. Greek practitioners of the minor arts of medicine, such as bath-keepers, corn-cutters, tooth-drawers, and herbalists crowded into the great city as it became rich, and opened shops which were known as “medicinas,” and it is likely that most of these brought with them a more or less famous “hiera,” claiming that it had been compounded from a genuine Temple formula.

Leclerc, an excellent authority on all matters concerning ancient medicine, attributes the first Hiera to Themison of Laodicea, who practised in Rome about 50 B.C., and who is reputed to have been the first physician to make use of leeches. The Hiera of Themison was composed of 100 drachms of aloes, with 1 oz. each of mastic, saffron, Indian nard, carpobalsamum, and asarum.

The Hiera of Galen, which was modified from that of Archigenes, was originally in the following form:--

Socotrine aloes, 100; cinnamon, spikenard, xylobalsamum, mastic, asarum, and saffron, of each 6; honey to make an electuary. In the P.L. this was ordered to be kept in the form of species, and was principally used to make a tincture which was called tinctura sacra. In the 1721 edition the mastic and the spikenard were omitted, cardamom seeds being substituted for the latter, and some cochineal was added with a view to colouring the tincture. In 1746 hiera picra became simply a mixture of aloes and canella, and as such it was retained in the following edition (1788), but under the title of Pulv. Aloeticus, which in the Index is given as “olim Hiera Picra.” This was the latest reference to Hiera Picra as such in the London Pharmacopœia. The P.L. of 1788 gave also a Pulv. Aloeticus c. Guaiaco, which consisted of 1½ oz. of Socotrine aloes, 1 oz. of powdered guaiacum, and ½ oz. of aromatic powder (afterwards called Pulv. Cinnamomi Co., and compounded of cinnamon, cardamoms, ginger, and long pepper). The canella mixture did not appear again, but that with guaiacum was repeated in all the subsequent London Pharmacopœias including the last in 1851, but was dropped from the British Pharmacopœias.

Pil. Rufi, our Myrrh and Aloes pill, was originally a Hiera invented by Rufus of Ephesus, who lived in the reign of the Emperor Trajan. The Hiera was made into pills by the Arabs, and were for a long time known as Pilulæ Pestilentiales, which was the name Avicenna gave them. In the early Edinburgh Pharmacopœias they were called Pilulæ Communes.

Scribonius Largus, physician to the Emperor Tiberius, relates (A.D. 52) that one of these noted hieras, the Hiera Pachii, was much sought after, and that large sums had been offered for the formula. When Pachius died at Antioch the Emperor had his library searched, and the true recipe for the famous medicine was there found in a book which Pachius had prepared and had dedicated to the Emperor. Tiberius handed the formula to Scribonius with instructions for its publication. The formula given by Scribonius, which it will be noted contained no aloes, was as follows:--Colocynth, agaric, germander, white horehound, Arabian stœches (a sort of lavender), of each ℥x; opoponax, sagapenum, parsley seeds, round birthwort root, white pepper, of each ℥v; spikenard, cinnamon, myrrh, and saffron, of each ℥iv; despumated honey, 3 lb. 3 oz. 5 drachms, to make an electuary.

It is not necessary to describe the other hieras devised by later authorities, but it may be noted that the Hiera Tralliani compounded by Alexander of Tralles (about 550 A.D.) contained scammony, and that he advises concerning it that the quantity of scammony shall not be increased, as it appears some were inclined to do, not knowing that thereby they make it useless. For he says it is not the intention that the medicine should be carried immediately through the system. It should be detained in the body and conveyed to the remote parts so as to correct the various humours, open the passages, remove the obstructions of the nerves, and make way for the motion of the spirits. This was the formula given in the P.L. 1721 under the name of Hiera Diacolocynthidis, but our present-day hiera picra has descended from the Hiera Simplex of Galen. The old dispensatories up to the eighteenth century give a liberal choice of Hieras, among which were the Hiera Simplex Galeni cum Agarice, Hiera Logadii, Hiera Antiochi, Hiera Archigenes, Hiera Tralliani, Hiera Rufi, Hiera Justi, Hiera Constantini, and others. Originally these were all electuaries made with honey. It became the practice, however, to keep them in the form of “species,” and ultimately electuaries went out of fashion altogether.

LAUDANUM.

Paracelsus probably invented the name of laudanum, and seems to have called several medicines by that term. In one place he expressly states that his laudanum was made from gold leaf and unperforated pearls; in other places he seems to mean red precipitate, and undoubtedly opium or a compound of it was sometimes intended. Crollius gives a formula for a pill mass, which he designates the laudanum of Paracelsus, which contained one-fourth of its weight of opium, to which were added henbane juice, mummy, salts of pearls and corals, the bone of the heart of a stag, bezoar stone, amber, musk, unicorn, and some species, with a few drops of many of the essential oils. The Anodynum Specificum of Paracelsus was a product obtained by first digesting opium, 4, in a mixture of orange and lemon juices, 180, with distilled frogs’ sperm water, to which cinnamon, 4, cloves, 45, ambergris, 4, and saffron, 45, were added. This mixture was digested for a month, and after pressing and straining, coral, magistery of pearl, and quintessence of gold, of each 2, were added, together with the salt extracted from the marc.

The laudanum of the early London Pharmacopœias was a pill mass made as follows:--Thebaic opium extracted by spirit of wine, ℥i.; saffron, similarly extracted, ℥iss; castorum, ℥i; combined with ℥ss. of species of diambræ made into a tincture with spirit of wine; to these might be added, ex-gratia, ambergris and musk, of each 6 gr., and oil of nutmeg 10 drops. Evaporate the moisture and leave the mass.

One would think that the name laudanum was an echo of laudandum, and that has been the usual opinion. But Professor Skeat is confident that it is a variation of ladanum, which, he says, was a stomachic cordial made and named from gum labdanum, which had been in medical use for centuries. This, of course, is possible, but it must be remembered that Paracelsus was untrammelled by any etymological rules in his invented words, and that the one unlikely thing for him to do would have been to adopt with a slight modification the name of a remedy then in use, if, indeed, a preparation of labdanum was at that time popular, or even known at all in Germany in his time.[2] Adam of Bodenstein, son of the theologian Carolstadt, who wrote both for and against Luther’s doctrines, wrote a treatise in which he professed to explain all the mysterious terms used by Paracelsus. Laudanum, he says, is from _a laude_, and was a quintessence of mercury and not an opiate.

Sydenham’s Laudanum is the preparation of opium which attained the highest popularity. It has always been the principal liquid preparation of the drug in continental practice, and formulas for it more or less corresponding with the original are in all the principal Pharmacopœias except the British. It was omitted from the P.L. in 1746, or rather a very similar preparation named Tinctura Thebaiaca was substituted for it. Sydenham’s formula, which was given incidentally in his description of the dysentery of 1669–72, prescribed strained opium, 2 oz., saffron 1 oz., cinnamon and cloves of each 1 drachm, and Canary wine, 1 pint.

“I do not think this preparation has more virtue than the solid laudanum of the shops,” he wrote; “but I prefer it before that for its more commodious form, and by reason of the greater certainty of the dose, for it may be dropped into wine or any distilled water, or into any other liquor.”

This passage is quoted from Pechey’s translation of Sydenham’s works. The allusion to “the solid laudanum of the shops” confirms the opinion that Sydenham’s was the first liquid preparation generally designated laudanum. Among the Sloane manuscripts in the British Museum is included what is described as “The Commonplace Book of an Apothecary at Great Dunmow,” which contains several more or less similar recipes for laudanum. The book is dated 1644–5. The most elaborate formula is headed “Laudanum Josephi Michælis,” and lengthy directions for making this are given. The ingredients were opium, extract of henbane, species diambræ (a compound of most of the known spices), pearls, coral, amber, musk, mummy, cloves, and oil of cloves. Some of these were to be extracted with spirit of wine, and the spirituous extracts were to be distilled. Ultimately the whole was to be set aside to ferment for three months. The dose was stated to be 4 or 5 grains at bedtime.

Rousseau’s laudanum, which also became famous among opium preparations, differed from others in being a fermented compound. It was made by dissolving 12 oz. of honey in 3 lb. of warm water, and setting the mixture in a warm place. When it began to ferment, 4 oz. of opium mixed with 12 oz. of water were added, and the fermentation was allowed to continue at a moderate temperature for a month. After straining, the liquid was evaporated to 10 oz., and 4½ oz. of alcohol were added.

Rousseau was a Capuchin monk and was destined for mission work in Asia. Sent from Rome to Paris to study medicine so that he might be better fitted for his life’s work, he carried a letter of introduction to Colbert, the first minister of Louis XIV. Rooms were provided for him in the Louvre, and there before long he set up a laboratory and began to prepare and sell medicines. The Capucin of the Louvre became the fashionable quack, and Louis ordered the Faculty of Medicine to confer on him a degree. The life was so agreeable that, when orders came from Rome that he was to proceed on his mission, Rousseau refused, and, having transferred his allegiance to the order of Cluny, he continued his medical practice in Paris. Falling ill he refused medical aid, treated himself with his own compounds, and died. After his death his brother published his “Remédes et Secréts Eprouvés” (1697).

Black Drop was the name of a celebrated proprietary medicine very popular from the first half of the eighteenth, until the early part of the nineteenth century. Its inventor was one Edward Runstall of Bishop Auckland in the county of Durham, but it also came to be known as the Lancaster or the Quaker’s Black Drop. A formula for it was found by a Dr. Armstrong among the papers of a relative of the proprietor, and was published in a treatise on fevers in the early part of the nineteenth century. The recipe was as follows:--Opium, ½ lb.; good verjuice (the juice of the wild crab), 4 pints; nutmegs, 1½ oz.; saffron, ½ oz. Boil to a proper consistence, set in a warm place, add two spoonfuls of yeast, set in a warm place for six or eight weeks, then in the open air until it becomes of the consistence of syrup. Decant, filter, and bottle, putting a little sugar into each bottle.

This preparation was three times the strength of laudanum. The acetum opii of the Edinburgh and Dublin Pharmacopœias was intended as a substitute, but closer approximations to the original formula were given in the Hamburg Codex of 1845 and in the U.S. Pharmacopœia of 1851. The growing favour with which morphine was regarded gradually destroyed the popularity of the Black Drop.

TINCTURA LAVANDULÆ COMPOSITA

has much fallen from its earlier glories. In the P.L., 1721, it was made with French brandy and twenty-seven other ingredients, including besides lavender, sage, rosemary, betony, borage, lilies of the valley, cowslips, balm, orange flowers, bay berries, cinnamon, mace, nutmegs, cardamoms, cubebs, aloes wood, ambergris, saffron, musk roses, and a few other less familiar flowers or cordials. The preparation was known as Palsy Drops, but I am not sure whether the official compound acquired this title, or whether it was an imitation of a tincture previously known as such.

LENITIVE ELECTUARY.

The formula prescribed in the first London Pharmacopœia was as follows:--Raisins (stoned), polypody of the oak, Eastern senna, of each 2 oz.; herb mercury, 1½ handful; jujubes and sebestens, of each 20; maidenhair, violets, and cleaned barley, of each 1 handful; prunes (stoned), tamarinds, of each 6 drachms; liquorice, ½ oz.

These drugs were to be boiled in 10 lb. of water to one-third of its volume, and to the strained liquor were to be added pulp of cassia fistula, tamarinds, prunes, sugar of violets, of each 6 oz.; sugar, 2 lb.; and at last 1½ oz. of powdered senna was to be incorporated to each pound of the electuary.

In the Pharmacopœia of 1650 powdered aniseed, 2 drachms to each pound of the electuary, was added in order to correct the action of the senna.

In 1721 figs (20) took the place of the jujubes and sebestens; and powdered coriander seeds were substituted for the aniseed.

In the Pharmacopœia of 1746 the preparation was much simplified, the raisins, polypody, herb mercury, maidenhair, violets, and barley, being rejected. The formula then adopted was very nearly the same as the one now prescribed, but the name of the compound was changed in 1851 to Confection of Senna.

As in the case of most other medicines, the dose of this compound has been gradually reduced. There was more senna in proportion to the finished product in the old formulas than in the modern ones; but the dose was stated by Culpepper to be “one ounce for a man of reasonable strength.” Later a piece the size of a walnut was recommended; now the official dose is 1 to 2 drachms.

For a long time this preparation was grossly adulterated. “I understand,” says Paris, “that a considerable quantity is manufactured in Staffordshire in which unsound or spoilt apples are an ingredient; that jalap blackened with walnut liquor is frequently substituted for pulp of cassia; and that the great bulk of what is sold in London is little else than prunes, figs, and jalap.”

COMPOUND LIQUORICE POWDER.

Although this popular medicine was only made official by being adopted in the B. P. Additions, 1874, it had already acquired reputation as a pleasant laxative in household medicine, and had been familiar in German pharmacy for the better part of a century. It first appeared in the Prussian Pharmacopœia in 1799, and had been devised by a noted physician of Berlin, Dr. E. G. Kurella, who died in the year named. He called the mixture Pectoral Powder, and he made an electuary from similar ingredients.

The Prussian powder looks like a modification of a compound senna powder included in the first London Pharmacopœia, 1618. This contained senna, liquorice, caraway, fennel, cumin, spikenard, cinnamon, galangal, and gromwell seeds. Its “first contriver” (says Quincy) was Isaac Hollandicus.

OPODELDOC.