CHAPTER II

VESALIUS AND THE OVERTHROW OF AUTHORITY IN SCIENCE

Vesalius, although an anatomist, is to be recognized in a broad sense as one of the founders of biology. When one is attempting to investigate animal and plant life, not only must he become acquainted with the external appearance of living organisms, but also must acquire early a knowledge of their structure, without which other facts relating to their lives can not be disclosed. Anatomy, which is the science of the structure of organized beings, is therefore so fundamental that we find ourselves involved in tracing the history of its rise as one part of the story of biology. But it is not enough to know how animals and plants are constructed; we must also know something about the purpose of the structures and of the life that courses through them, and, accordingly, after considering the rise of anatomy, we must take a similar view of its counterpart, physiology.

The great importance of Vesalius in the history of science lies in the fact that he overthrew adherence to authority as the method of ascertaining truth, and substituted therefor observation and reason. Several of his forerunners had tried to accomplish the same end, but they had failed. He was indebted to them as every man is indebted to his forebears, but at the same time we can not fail to see that Vesalius was worthy of the victory. He was more resolute and forceful than any of his predecessors. He was one of those rare spirits who see new truth with clearness, and have the bravery to force their thoughts on an unsympathetic public.

The Beginning of Anatomy.--In order to appreciate his service it is necessary to give a brief account of his predecessors, and of the condition of anatomy in his time. Remembering that anatomy embraces a knowledge of the architecture of all animals and plants, we can, nevertheless, see why in early times its should have had more narrow boundaries. The medical men were the first to take an interest in the structure of the human body, because a knowledge of it is necessary for medicine and surgery. It thus happens that the earliest observations in anatomy were directed toward making known the structure of the human body and that of animals somewhat closely related to man in point of structure. Anatomical studies, therefore, began with the more complex animals instead of the simpler ones, and, later, when comparative anatomy began to be studied, this led to many misunderstandings; since the structure of man became the type to which all others were referred, while, on account of his derivation, his structure presents the greatest modification of the vertebrate type.

It was so difficult in the early days to get an opportunity to study the human body that the pioneer anatomists were obliged to gain their knowledge by dissections of animals, as the dog, and occasionally the monkey. In this way Aristotle and his forerunners learned much about anatomy. About 300 B.C., the dissection of the human body was legalized in the Alexandrian school, the bodies of condemned criminals being devoted to that purpose. But this did not become general even for medical practitioners, and anatomy continued to be studied mainly from brute animals.

Galen.--The anatomist of antiquity who outshines all others was Galen (Claudius Galenus, 130-200 A.D.), who lived some time in Pergamos, and for five years in Rome, during the second century of the Christian era. He was a man of much talent, both as an observer and as a writer. His descriptions were clear and forceful, and for twelve centuries his works exerted the greatest influence of those of all scientific writers. In his writings was gathered all the anatomical knowledge of his predecessors, to which he had added observations of his own. He was a man of originality, but not having the human body for dissection, he erred in expounding its structure "on the faith of observations made on lower animals." He used the right method in arriving at his facts. Huxley says: "No one can read Galen's works without being impressed with the marvelous extent and diversity of his knowledge, and by his clear grasp of those experimental methods by which alone physiology can be advanced."

Anatomy in the Middle Ages.--But now we shall see how the arrest of inquiry already spoken of operated in the field of anatomy. The condition of anatomy in the Middle Ages was the condition of all science in the same period. From its practical importance anatomy had to be taught to medical men, while physics and chemistry, biology and comparative anatomy remained in an undeveloped state. The way in which this science was taught is a feature which characterizes the intellectual life of the Middle Ages. Instead of having anatomy taught by observations, the writings of Galen were expounded from the desk, frequently without demonstrations of any kind. Thus his work came to be set up as the one unfailing authority on anatomical knowledge. This was in accord with the dominant ecclesiastical influence of the time. Reference to authority was the method of the theologians, and by analogy it became the method of all learning. As the Scriptures were accepted as the unfailing guide to spiritual truth, so Galen and other ancient writers were made the guides to scientific truth and thought. The baneful effects of this in stifling inquiry and in reducing knowledge to parrot-like repetition of ancient formulas are so obvious that they need not be especially dwelt upon.

Predecessors of Vesalius.--Italy gave birth to the first anatomists who led a revolt against this slavery to authority in scientific matters. Of the eminent anatomists who preceded Vesalius it will be necessary to mention only three. Mundinus, or Mondino, professor at the University of Bologna, who, in the early part of the fourteenth century, dissected three bodies, published in 1315 a work founded upon human dissection. He was a man of originality whose work created a sensation in the medical world, but did not supersede Galen's. His influence, although exerted in the right direction, was not successful in establishing observation as the method of teaching anatomy. His book, however, was sometimes used as an introduction to Galen's writings or in conjunction with them.

The next man who requires notice is Berengarius of Carpi, who was a professor in the University of Bologna in the early part of the sixteenth century. He is said to have dissected not less than one hundred human bodies; and although his opportunities for practical study were greater than those of Mondino, his attempts to place the science of anatomy upon a higher level were also unsuccessful.

We pass now from Italy to France, where Sylvius (1478-1555), one of the teachers of Vesalius, made his mark. His name is preserved to-day in the _fissure of Sylvius_ in the brain, but he was not an original investigator, and he succeeded only in "making a reputation to which his researches do not entitle him." He was a selfish, avaricious man whose adoption of anatomy was not due to scientific interest, but to a love of gain. At the age of fifty he forsook the teaching of the classics for the money to be made by teaching anatomy. He was a blind admirer of Galen, and read his works to medical students without dissections, except that from time to time dogs were brought into the amphitheater and their structure exposed by unskilled barbers.

Vesalius.--Vesalius now came upon the scene; and through his efforts, before he was thirty years of age, the idol of authority had been shattered, and, mainly through his persistence, the method of so great moment to future ages had been established. He was well fitted to do battle against tradition--strong in body, in mind, and in purpose, gifted and forceful; and, furthermore, his work was marked by concentration and by the high moral quality of fidelity to truth.

Vesalius was born in Brussels on the last day of the year 1514, of an ancestry of physicians and learned men, from whom he inherited his leaning toward scientific pursuits. Early in life he exhibited a passion for anatomy; he dissected birds, rabbits, dogs, and other animals. Although having a strong bent in this direction, he was not a man of single talent. He was schooled in all the learning of his time, and his earliest publication was a translation from the Greek of the ninth book of _Rhazes_. After his early training at Brussels and at the University of Louvain, in 1533, at the age of 18, he went to Paris to study medicine, where, in anatomy, he came under Sylvius and Günther.

His Force and Independence.--His impetuous nature was shown in the amphitheatre of Sylvius, where, at the third lecture, he pushed aside the clumsy surgeon barbers, and himself exposed the parts as they should be. He could not be satisfied with the exposition of the printed page; he must see with his own eyes, must grasp through his own experience the facts of anatomical structure. This demand of his nature shows not only how impatient he was with sham, but also how much more he was in touch with reality than were the men of his time.

After three years at the French capital, owing to wars in Belgium, he went back to Louvain without obtaining his medical degree. After a short experience as surgeon on the field of battle, he went to Padua, whither he was attracted by reports of the opportunities for practical dissection that he so much desired to undertake. There his talents were recognized, and just after receiving his degree of Doctor of Medicine in 1537, he was given a post in surgery, with the care of anatomy, in the university.

His Reform of the Teaching of Anatomy.--The sympathetic and graphic description of this period of his career by Sir Michael Foster is so good that I can not refrain from quoting it: "He at once began to teach anatomy in his own new way. Not to unskilled, ignorant barbers would he entrust the task of laying bare before the students the secrets of the human frame; his own hand, and his own hand alone, was cunning enough to track out the pattern of the structures which day by day were becoming more clear to him. Following venerated customs, he began his academic labors by 'reading' Galen, as others had done before him, using his dissections to illustrate what Galen had said. But, time after time, the body on the table said something different from that which Galen had written.

"He tried to do what others had done before him--he tried to believe Galen rather than his own eyes, but his eyes were too strong for him; and in the end he cast Galen and his writings to the winds, and taught only what he himself had seen and what he could make his students see, too. Thus he brought into anatomy the new spirit of the time, and the men of the time, the young men of the time, answered the new voice. Students flocked to his lectures; his hearers amounted, it is said, to some five hundred, and an enlightened senate recognized his worth by repeatedly raising his emoluments.

"Five years he thus spent in untiring labors at Padua. Five years he wrought, not weaving a web of fancied thought, but patiently disentangling the pattern of the texture of the human body, trusting to the words of no master, admitting nothing but that which he himself had seen; and at the end of the five years, in 1542, while he was as yet not twenty-eight years of age, he was able to write the dedication to Charles V of a folio work entitled the 'Structure of the Human Body,' adorned with many plates and woodcuts which appeared at Basel in the following year, 1543."

His Physiognomy.--This classic with the Latin title, _De Humani Corporis Fabrica_, requires some special notice; but first let us have a portrait of Vesalius, the master. Fig. 4 shows a reproduction of the portrait with which his work is provided. He is represented in academic costume, probably that which he wore at lectures, in the act of demonstrating the muscles of the arm. The picture is reduced, and in the reduction loses something of the force of the original. We see a strong, independent, self-willed countenance; what his features lack in refinement they make up in force; not an artistic or poetic face, but the face of the man of action with scholarly training.

His Great Book.--The book of Vesalius laid the foundation of modern biological science. It is more than a landmark in the progress of science--it created an epoch. It is not only interesting historically, but on account of the highly artistic plates with which it is illustrated it is interesting to examine by one not an anatomist. For executing the plates Vesalius secured the service of a fellow-countryman, John Stephen de Calcar, who was one of the most gifted pupils of Titian. The drawings are of such high artistic quality that for a long time they were ascribed to Titian. The artist has attempted to soften the necessarily prosaic nature of anatomical illustrations by introducing an artistic background of landscape of varied features, with bridges, roads, streams, buildings, etc. The employment of a background even in portrait-painting was not uncommon in the same century, as in Leonardo da Vinci's well-known Mona Lisa, with its suggestive perspective of water, rocks, etc.

Fig. 5 will give an idea on a small scale of one of the plates illustrating the work of Vesalius. The plates in the original are of folio size, and represent a colossal figure in the foreground, with a background showing between the limbs and at the sides of the figure. There is considerable variety as regards the background, no two plates being alike.

Also, in delineating the skeleton, the artist has given to it an artistic pose, as is shown in Fig. 6, but nevertheless the bones are well drawn. No plates of equal merit had appeared before these; in fact, they are the earliest generally known drawings in anatomy, although woodcuts representing anatomical figures were published as early as 1491 by John Ketham. Ketham's figures showed only externals and preparations for opening the body, but rude woodcuts representing internal anatomy and the human skeleton had been published notably by Magnus Hundt, 1501; Phrysen, 1518; and Berengarius, 1521 and 1523. Leonardo da Vinci and other artists had also executed anatomical drawings before the time of Vesalius.

Previous to the publication of the complete work, Vesalius, in 1538, had published six tables of anatomy, and, in 1555, he brought out a new edition of the _Fabrica_, with slight additions, especially in reference to physiology, which will be adverted to in the chapter on Harvey.

In the original edition of 1543 the illustrations are not collected in the form of plates, but are distributed through the text, the larger ones making full-page (folio) illustrations. In this edition also the chapters are introduced with an initial letter showing curious anatomical figures in miniature, some of which are shown in Fig. 7.

The _Fabrica_ of Vesalius was a piece of careful, honest work, the moral influence of which must not be overlooked. At any moment in the world's history, work marked by sincerity exercises a wholesome influence, but at this particular stage of intellectual development such work was an innovation, and its significance for progress was wider and deeper than it might have been under different circumstances.

Opposition to Vesalius.--The beneficent results of his efforts were to unfold afterward, since, at the time, his utterances were vigorously opposed from all sides. Not only did the ecclesiastics contend that he was disseminating false and harmful doctrine, but the medical men from whom he might have expected sympathy and support violently opposed his teachings.

Many amusing arguments were brought forward to discredit Vesalius, and to uphold the authority of Galen. Vesalius showed that in the human body the lower jaw is a single bone--that it is not divided as it is in the dog and other lower mammals, and, as Galen had taught, also in the human subjects. He showed that the sternum, or breast bone, has three parts instead of eight; he showed that the thigh bones are straight and not curved, as they are in the dog. Sylvius, his old teacher, was one of his bitterest opponents; he declared that the human body had undergone changes in structure since the time of Galen, and, with the object of defending the ancient anatomist, "he asserted that the straight thigh bones, which, as every one saw, were not curved in accordance with the teaching of Galen, were the result of the narrow trousers of his contemporaries, and that they must have been curved in their natural condition, when uninterfered with by art!"

The theologians also found other points for contention. It was a widely accepted dogma that man should have one less rib on one side, because from the Scriptural account Eve was formed from one of Adam's ribs. This, of course, Vesalius did not find to be the case. It was also generally believed at this time that there was in the body an indestructible resurrection-bone which formed the nucleus of the resurrection-body. Vesalius said that he would leave the question of the existence of such a bone to be decided by the theologians, as it did not appear to him to be an anatomical question.

The Court Physician.--The hand of the church was heavy upon him, and the hatred shown in attacks from various quarters threw Vesalius into a state of despondency and anger. In this frame of mind he destroyed manuscripts upon which he had expended much labor. His disappointment in the reception of his work probably had much to do in deciding him to relinquish his professorship and accept the post of court physician to Charles V of the United Kingdoms of Spain and Belgium. After the death of Charles, he remained with Philip II, who succeeded to the throne. Here he waxed rich and famous, but he was always under suspicion by the clerical powers, who from time to time found means of discrediting him. The circumstances of his leaving Spain are not definitely known. One account has it that he made a _post-mortem_ examination of a body which showed signs of life during the operation, and that he was required to undertake a pilgrimage to the Holy Land to clear his soul of sacrilege. Whether or not this was the reason is uncertain, but after nineteen years at the Spanish Court he left, in 1563, and journeyed to Jerusalem. On his return from Palestine he suffered shipwreck and died from the effects of exposure on Zanti, one of the Ionian Islands. It is also said that while on this pilgrimage he had been offered the position of professor of anatomy as successor to Fallopius, who had died in 1563, and that, had he lived, he would have come back honorably to his old post.

Eustachius and Fallopius.--The work of two of his contemporaries, Eustachius and Fallopius, requires notice. Cuvier says in his _Histoire des Sciences Naturelles_ that those three men were the founders of modern anatomy. Vesalius was a greater man than either of the other two, and his influence was more far-reaching. He reformed the entire field of anatomy, while the names of Eustachius and Fallopius are connected especially with a smaller part of the field. Eustachius described the Eustachian tube of the ear and gave especial attention to sense organs; Fallopius made special investigations upon the viscera, and described the Fallopian tube.

Fallopius was a suave, polite man, who became professor of anatomy at Padua; he opposed Vesalius, but his attacks were couched in respectful terms.

Eustachius, the professor of anatomy at Rome, was of a different type, a harsh, violent man, who assailed Vesalius with virulence. He corrected some mistakes of Vesalius, and prepared new plates on anatomy, which, however, were not published until 1754, and therefore did not exert the influence upon anatomical studies that those of Vesalius did.

The Especial Service of Vesalius.--It should be remembered that both these men had the advantage of the sketches made under the direction of Vesalius. Pioneers and path-breakers are under special limitations of being in a new territory, and make more errors than they would in following another's survey of the same territory; it takes much less creative force to correct the errors of a first survey than to make the original discoveries. Everything considered, Vesalius is deserving of the position assigned to him. He was great in a larger sense, and it was his researches in particular which re-established scientific method and made further progress possible. His errors were corrected, not by an appeal to authority, but by the method which he founded. His great claim to renown is, not that his work outshone all other work (that of Galen in particular) in accuracy and brilliancy, but that he overthrew dependence on authority and re-established the scientific method of ascertaining truth. It was the method of Aristotle and Galen given anew to the world.

The spirit of progress was now released from bondage, but we have still a long way to go under its guidance to reach the gateway of modern biology.