Part 7

I had provided for this purpose a pile composed of eighty pieces of silver and zinc, and I at first administered the Galvanism gradually, forming the arc by means of the hands. Lanzarini, in a state of the utmost dejection, viewed the apparatus and the company present with his eyes fixed and motionless. When interrogated by the physicians and myself in regard to the origin of his malady, he gave laconic and confused answers, which seemed to indicate a great degree of stupidity and derangement. I first moistened his hands, and formed an arc with the pile at different heights, to accustom him to endure the action of the apparatus. No change, however, was produced in the patient by this operation. I then repeated the experiment, placing his hands, moistened with salt water, at the bottom of the pile; and conveying an arc from the summit of the pile to different parts of his face, moistened with the same solution. A change was soon observed in the patient’s countenance, and his whole demeanour seemed to indicate that the degree of his melancholy was somewhat lessened. The experiment was repeated several times with the same success; which seems to prove that Galvanism absolutely exercises an action in such diseases. The patient being interrogated next day, asserted that he had felt no inconvenience from the application of the Galvanism; and this account was confirmed by the keepers, who had been desired to give a report of the least change that might take place. Similar results were obtained by gradually administering the action of the pile with greater force for several days successively, and we soon began to observe that it produced a very striking effect. The patient, on touching the apparatus, seemed to acquire new spirits; a smile appeared on his countenance, and a complete change took place in his eyes as well as in every feature of his face. Instead of showing any aversion to the pile, he readily obeyed whenever he was called to undergo the operation; and his whole conduct indicated that he found relief from the influence of the unknown agent which it excited. He began to converse with more readiness, sometimes respecting the machine, and sometimes on the flash of light which appeared in his eyes when the arc was applied; and on that account we conceived the most flattering hopes of a complete cure. The result of this operation induced me to administer the Galvanism even to the substance of the brain; being convinced, as I have already remarked, that the Galvanic fluid by this method of application exercises its action with greater energy. I communicated my design to the Professors of the hospital, and with their approbation began to try the effects of a pile composed of fifteen plates of copper and zinc. I formed an arc from one of the hands to one of the ears, and then from one ear to another, having first moistened them with a solution of muriate of soda. I increased the number of plates of which the pile was composed, and found that the patient was always more or less affected with a momentary impression exceedingly painful, which however seemed in the end to produce a good effect. When Galvanism was administered in this manner, I did not neglect to continue the application of the other method at the same time; and I found that the progress of the cure became more rapid. But as I observed that the action of Galvanism on the ears was sometimes too violent, we thought proper to apply it in a more moderate and less dangerous manner. Several persons having been induced through curiosity to try this action, the result, besides a violent commotion of the whole substance of the brain against the skull, was a state of watchfulness which continued several days running, and which I experienced myself as well as others. We then conceived the idea of shaving the head above the suture of the parietal bone (Plate III. fig. 3.); and having moistened the shaven part with salt water, a piece of gold or silver coin was placed over it. The patient then touched with one of his hands the bottom of the pile, and at the same time an arc was established from the summit of the pile to the metallic armature placed on the head. By this arrangement the action of the Galvanism was rendered more moderate; the patient endured it for a long time, and seemed to be greatly relieved by it. I have always united this method with external application to different parts of the face, and have observed such sudden changes in the looks as seemed to announce a considerable abatement of the disease. Some of the physicians of Bologna, Professors Brugnatelli and Zola of Pavia, and several other foreigners, examined and confirmed the permanency of this effect. The patient, therefore, not only got the better of his melancholy, but began to relish his food, and at length recovered so much strength that the physicians of the hospital thought nothing further was necessary to complete the cure.

No other remedy besides Galvanism was administered to him, lest the effects should be so confounded as to render it impossible to tell to which the cure ought to be ascribed. Two days, however, before he left the hospital a little blood was taken from him; as it was conceived that this operation might contribute to render the cure more certain.

On his leaving the hospital I carried him to my house, that he might be fitted by proper nourishment for resuming his former occupations. He remained with me eight days in the quality of a domestic, during which time he was exceedingly tractable, and performed his duty with great care and attention. I had several conversations with him, in the course of which I learned that his father, Fabian Lanzarini, had been attacked by the same disease, and that he had been admitted into the same hospital, where he died on the 12th of June 1790. By inspecting the registers of the hospital, I found this account to be perfectly correct.

Agreeably to the principles already established, in regard to the treatment of madness, I advised Lanzarini to spend the rest of his life at a distance from his native country, lest, having continually before his eyes those objects which had occasioned his disease, it might recur with double violence. But though he had given me several proofs of his docility, I found it impossible to persuade him to make this sacrifice. A kind of _nostalgia_, perhaps, attached him to his former master, to whom he returned, after paying a visit to the curé of the parish. The latter, when he first saw him, imagined he had run away from the hospital; but by his conversation he was soon convinced of his being completely cured. After this period, I obtained a regular report respecting his behaviour and the state of his health, from the above curé, and from the person who had paid all the expenses of his residence in the hospital; and I learned, with great satisfaction, that he continued to enjoy good health, and to exercise his usual employment.

By the same treatment I cured, of a similar disorder, Charles Bellini, a labourer, who was restored to society in a shorter space of time, because the affection was not so violent as in the preceding case. The phænomena which took place when the patient was subjected to the action of the pile, when the Galvanism was applied to the brain, and during the whole progress of the cure, were nearly the same. I must, however, freely acknowledge, that two cures are not sufficient to establish the application of Galvanism as an universal remedy in such cases. But on this account it ought not to be rejected: at any rate it deserves further examination; for it is well known that all remedies require certain conditions before they can perform their effect. I have therefore several times found it impossible to obtain the same result in other patients afflicted with melancholy madness, to whom I administered Galvanism; and in cases of raving madness I have even found it dangerous. In some instances, melancholy madness derives its origin from a certain general constitution of the animal machine, or from some great alteration in the brain; and it is evident that in such cases the action of Galvanism would be of no avail. But if the derangement of the intellectual functions depend only on some humour intercepted between the membranes and other parts of the brain, there is reason to hope that Galvanism, if prudently administered, may be attended with great benefit. The real cases in which it may be administered with success, can be ascertained only by experience. I must observe also, that the method of administering it is not yet reduced to that state of simplicity, which is necessary before it can be brought into regular use in large hospitals. The physicians, under whose care they are placed, have in general a great deal of private practice, and cannot conveniently attend to operations which require a continued labour for several months. Besides, the novelty of the remedy is sufficient to excite a clamour against it, and to awaken the prejudice of the assistants, who will even wish to proscribe it before it has been tried. For this reason, I think it necessary here to request, that those who preside over establishments destined for the reception of such patients would turn their attention to this subject, and endeavour to reduce the method of applying Galvanism to the utmost simplicity of which it is susceptible, in order that it may be fit for being introduced into large hospitals. As the patient often shows an aversion to this strange remedy, it will be necessary to encourage him by every means possible. Sometimes on observing the flash of light, when the Galvanism is communicated, he cries out and is frightened; imagining that he sees a devouring fire ready to consume him, and on this account refuses to submit again to the operation. It will, therefore, be proper to conceal from him the apparatus, or to make a person show him the pile some time before as an object of amusement, and in this manner to prepare him for receiving its action. It will be of benefit also sometimes to modify the action of the pile, and to render it more moderate by a different method of application. In the case of female patients I have found the result the same, when the Galvanism, instead of being applied directly to the interior part of the ears, was directed externally to the gold pendents (Plate III. fig. 4.).

By considering the course generally pursued in curing melancholy madness, hints may be suggested for an useful application of Galvanism in that disease, and data may be obtained sufficient to establish the different modes of application best fitted to the different cases. These ideas have engaged a good deal of my attention; and when I have finished the observations I have been for some time collecting, I flatter myself that I shall be able to communicate to the public some interesting information on the subject.

In some cases of madness, as I found it impossible to apply Galvanism to the hands, which were confined, I employed the action of an arc directed to the mouth (Plate III. fig. 2.), while another proceeded to one of the ears; or I applied a piece of money to the head, and communicated the Galvanism by the method already described (Plate III. fig. 3.).

It will even be necessary to try the effect of the Galvanic current, sometimes continued, and sometimes interrupted by means of the apparatus employed for diseases of the organs of hearing. It will be proper, in many cases, to combine moral with physical treatment, and not to neglect the other methods already known and practised, which may be used as very convenient auxiliaries.

SECTION V.

_General reflections on the action and influence which Galvanism, considered in a medical point of view, exercises on the animal œconomy._

I shall not here speak of the variation in insensible perspiration, and of the increase of circulation, which, according to the observations of several physicians, are found to be produced by Galvanism. Similar phænomena, as is well known, take place during the administration of common electricity. I shall therefore confine myself to those effects which hitherto have been produced only by the action of Galvanism. I shall observe in the first place, that Galvanism, as already shown in the Experiments detailed in the Second Part, is capable of effecting a separation of the fluids, and even sometimes of protruding the fæcal matters from the body. In the case of the decapitated malefactor, I found that when the arc was applied to one ear and to the lips, a very sensible portion of saliva was discharged from the mouth. This observation was confirmed at Genoa on the head of an ox, and in several other places on the heads of sheep. The phænomenon of the extrusion of the fæcal matters from the trunk of an ox, by means of Galvanism, was observed also by Professor Mojon of Genoa, and his brother, to take place in human bodies. Considering the animal fluids separately, I have found that very great variations are produced in them by Galvanism. But before I give an account of the experiments which I made on this subject, I shall describe the apparatus I employed.

The animal fluid destined to be exposed to the action of Galvanism is put into a glass vessel (Plate III. fig. 6.) covered by a wooden lid, having in it two holes equally distant from the centre. Two wires, one of brass and the other of plated copper, the upper extremities of which are bent into the form of a hook, pass through these holes in such a manner, that the lower extremities of them reach nearly to the bottom of the vessel, where they are bent at right angles, so that only a very small interval is left between them. The upper extremity of one is made to communicate with the bottom of the pile, and the other with the summit. In consequence of this arrangement the Galvanic fluid is obliged to traverse the animal fluid, by which means it exercises an action on it according to the distance of the wires, and by its action separates from its different strata sometimes one principle and sometimes another; and this secretion will be effected with more ease and in greater abundance, according as the action of the pile is stronger, and the capacity of the conductors more considerable.

EXPERIMENT I.

Having put into glass vessels four ounces of blood recently drawn from the vein of a person in good health, I left one of them exposed to the contact of the atmospheric air, and subjected the other to the action of the pile. In both these portions I observed a speedy coagulation of the crassamentum, and at the end of twenty-four hours the serous part was separated. The blood exposed to the action of the pile adhered so strongly to the two wires immersed in it, that it was difficult to separate them from the clot which was thus suspended in the aqueous fluid, but in the other vessel the clot remained at the bottom.

EXPERIMENT II.

I put two equal portions of bile, still warm, taken from the gall-bladder of an ox, into two glass vessels, exposed one of them to the contact of the air, and subjected the other to the action of the pile. After ten hours had elapsed, I observed that the bile in the latter had become so opake as no longer to afford a passage to the light; while the other portion, exposed to the atmosphere, retained its transparency and colour. I observed also a considerable disengagement of air, the nature of which I have not yet had an opportunity of examining.

EXPERIMENT III.

I took four ounces of urine, voided by a man in good health, exposed it to the action of the pile, and at the end of twenty-four hours found that the greater part of its constituent principles was separated. A portion of them was collected around the wires in such a manner as to form cylindric bodies of a considerable diameter, of which the wires were the axes. As the mass of the attracted matters increased, a portion fell to the bottom by its own weight. The cylinders were soon entirely destroyed, and the substances which formed them were precipitated by the least shock given to the vessel. I repeated this experiment lately in Mr. Wilson’s anatomical theatre in Windmill-street; and I observed, at the end of eighteen hours, a great quantity of the moleculæ furnished by the urine adhering to the two wires. But at length, not being able to withstand the effect of its gravitation, it began to fall down, forming a sort of wedge, the apex of which was at the surface of the urine, and the base at the bottom of the vessel.

EXPERIMENT IV.

Instead of putting the urine into a common apparatus, if a glass syphon with two platina wires be employed (Plate III. fig. 5.), the urine becomes limpid on the one side, and turbid on the other. The substance detached from the urine afterwards appears in the form of flakes, which are attracted by the platina wires. I observed this phænomenon for the first time in the company of those celebrated chemists Fourcroy and Vauquelin, while they were performing Galvanic experiments in their own laboratory.

EXPERIMENT V.

The substance above mentioned, which was precipitated to the bottom, when separated by filtration and dried, weighed about the fourth of a grain, and the fluid separated from it was of a greenish colour. On examining the earthy deposit of this urine, we obtained sulphate of lime by adding to it sulphuric acid.

EXPERIMENT VI.

Having exposed to the action of the pile, in the same manner, four ounces of urine voided by a person with jaundice, I obtained an earthy sediment, the weight of which was nearly equal to that above mentioned. The liquor separated from it was transparent, inclining a little to black. By the same chemical process I obtained sulphate of lime, though the sediment of the urine was somewhat dark, and afforded a portion of carbon and bile which inflamed in the fire.

EXPERIMENT VII.

Having repeated the above experiments with different kinds of urine, I observed in general, that Galvanism, by a peculiar attraction, separates from urine the sulphates and muriates united to a portion of the bile, and also to carbon, which in a great part are precipitated to the bottom of the vessel: the other part, which remains attached to the wires, exhibits a regular saline crystallization, of so singular a form that it seems worthy of becoming an object of further research to chemists.

The examination of urine voided by persons labouring under different kinds of disease, seems to be an object sufficient to excite the curiosity of physicians. To expose to the action of Galvanism artificial aëriform fluids, analogous to those which act a part in the animal œconomy, might also be attended with advantage. For this purpose it will be convenient to employ the apparatus represented in Plate III. fig. 7, which was lately constructed, with great precision, by M. Dumoutier at Paris. The whole artifice consists in a vertical metal tube, which can be raised up or pushed down. It is furnished with a stop-cock, and the tub in which the apparatus is placed has another. If the inverted bell be filled with water, and connected, by means of the vertical tube, with the apparatus which is to supply the gas, on opening the lower cock, the water will descend in the bell, and its place be supplied by the gas intended to be subjected to experiment.

From all the observations hitherto made, there seems to be reason to conclude, that the effects produced on the animal œconomy by common electricity and by the Galvanic pile are different. The phænomena of artificial Galvanism give us some right to suppose, that a similar action is exercised by the Galvanic fluid circulating in the fluids and in the organs of living animals. In this point of view Galvanic researches may one day throw great light on the nature of secretion; and it may perhaps be found necessary, when remedies are administered, to take its influence into consideration: for it is possible that the action of these remedies in the animal œconomy may depend on the establishment of such an arc between the system of the nerves and that of the muscles, as may not alter the natural state of the Galvanic fluid proper for the constitution of the individual to whom these remedies are administered. All this however is mere conjecture, and must be classed with many other things in the theory of Galvanism which are still involved in obscurity, and which we can hope to see explained only by new researches and new experiments.

Taking a general view of this Third Part, I must observe that the administration of Galvanism, when the above experiments are carefully examined, seems to appear in a much more advantageous point of view than before. I have indeed proved:

1st. That Galvanism, on many occasions, exercises an influence different from that of common electricity, and that it may be administered in various cases with great ease and safety.

2d. That the action of Galvanism manifests itself by a sensible attraction between the nervous and muscular parts; which seems to confirm the hypothesis of Humboldt, who supposes a Galvanic atmosphere peculiar to these parts when in a state of perfect vitality.

3d. That the strong impression made by Galvanism on the brain seems to explain its power on the organ of hearing; and therefore the physicians of Berlin, and other parts of Germany, are entitled to great praise for their researches on this subject.

4th. That though medicine is capable of affording considerable aid in cases of drowning and of asphyxia, it presents us with no means so powerful as Galvanism. The experiments made at London, Jan. 17, 1803, on the body of Forster, executed for murder, have fully convinced me of the activity of this stimulant.

5th. That in cases of melancholy madness, when other remedies fail, Galvanism may be employed with the greatest hopes of success, provided the disease does not proceed from a vitiated constitution, or a general derangement in the animal machine.

6th. That the current of the Galvanic fluid produces a great alteration in the animal fluids; separates a great many of their principles, and produces this effect in a particular manner in urine.

It is however much to be wished, that in addition to the knowledge already acquired in regard to Galvanism, some convenient method could be discovered of increasing or lessening its action on the animal fluids; by which means the advantages of the medical administration of this subtle agent would be rendered more certain and more effectual.

DISSERTATION

ON

_ANIMAL ELECTRICITY:_

READ IN THE

INSTITUTE OF BOLOGNA,

IN THE YEAR 1793,[3]

BY J. ALDINI.

I. While our Academy was congratulating itself on the progress made by the doctrine of animal electricity, its exultation was in some measure checked by an objection brought against it, which did not attack any one part of it, but the whole theory. If the contractions in animal bodies, said its opponents, are produced merely by the electricity of metals, how degraded is that electricity which at first was supposed to reside in animal bodies, since it is now found to be subservient to the electricity borrowed from metals! I heard repeated objections of this kind while labouring under a severe indisposition; but being restored to health by the skill and attention of Galvani, I took the earliest opportunity to inquire after the success of his animal electricity, and at the same time promised him every assistance in my power in the prosecution of his researches, for which I always entertained a great fondness. He accepted my offer; and as I had now recovered my former strength and vigour, I was anxiously desirous to defend the cause of animal electricity, attacked and almost exploded, amidst a variety of contradictory opinions, and with this view to undertake a new series of experiments.