Part 5
An assassin decapitated at Bologna, in the month of January 1802, afforded me an opportunity of verifying the truth of my former observations. In my first experiments on the human body, the dura and pia mater had been so little affected, that several of those present concluded that these parts were absolutely insensible to the action of the Galvanic pile; and this opinion was still further strengthened by the authority of several able anatomists. On the other hand, many warm-blooded animals, as will be seen hereafter, afforded contrary results. It is certain that nature, which is always consistent with itself in the action of that general principle which excites the muscular forces, ought to exhibit in the human body the same phænomena as those which constantly occur in other warm-blooded animals. I mentioned this anomaly to several of my colleagues, and particularly to that able anatomist Mondini, who, having made researches on this subject, communicated to me the result of them, and directed all the preparations necessary for the following experiments, modified according to the general views collected in the preceding observations.
EXPERIMENT XLIII.
The body of the criminal having been removed from the place of execution to a neighbouring apartment, the trunk was placed on one table, and the head on another. On the latter stood a pile, composed of a hundred plates of zinc and copper, and on the former, a pile of a hundred plates of silver and zinc. This apparatus tended greatly to facilitate the rapid performance of the experiments, which were made at the same time on all the parts of the body, and enabled us to take advantage of its great vitality. I had with me a select company of young physicians and surgeons, who, being much interested in the progress of Galvanism, assisted me with great ardour. They were divided into two parties, each of which was stationed around one of the tables, in order that the operations performed at the one might not interrupt those at the other. To gratify Professor Mondini, who was desirous of seeing the muscular action in the whole head, an arc was established from the spinal marrow to one of the ears, the pile being interposed between them, and strong contractions were produced in the whole face, as had been the case in all the other animals.
EXPERIMENT XLIV.
Having sawn through the scull with every possible precaution, and an arc being established from the dura mater to one of the ears, the usual contractions ensued. The pia mater was then uncovered, and, by employing the same means, the same results and the same effects were produced as had been obtained in other animals.
EXPERIMENT XLV.
The cortical substance in the left hemisphere was uncovered, and an arc being extended from it to the right ear, the movements of the face were exceedingly sensible in the part opposite to the uncovered hemisphere. I repeated the experiment different ways with the same results, and found, as I suspected, that this process put an end to the anomaly observed in regard to the membranes and cortical substance, which at first seemed to withstand the general action of the Galvanic fluid, though it produced an effect on the other parts of the brain. Dr. Mondini took care to remove the superfluous moisture, both from the membranes and cortical substance, in order to prevent all suspicion that it might facilitate a communication, in any manner, with the medullary substance.
EXPERIMENT XLVI.
Dr. Mondini, with his usual ability, having exposed in the brain the medullary substance, the corpora striata, the corpus callosum, the thalami nervorum opticorum, and the cerebellum, and an arc being formed of all these parts, we fully confirmed the results of the experiments which had been before made on the bodies of other criminals.
EXPERIMENT XLVII.
Having observed these phænomena in the head, we proceeded to the trunk, which gave us results no less interesting. The body was sound and robust, and indicated a constitution replete with vital energy. By forming an arc from the spinal marrow to the biceps muscle, very strong movements were produced throughout the whole body, and particularly in the arm, which could not be bent without very great exertion.
EXPERIMENT XLVIII.
By again applying the arc, according to the method detailed in the 41st experiment, the violence of the contractions was much increased. The trunk was thrown into strong convulsions; the shoulders were elevated in a sensible manner; and the hands were so agitated that they beat against the table which supported the body.
EXPERIMENT XLIX.
A silver probe was inserted into the spinal marrow, and one of the hands immersed in a solution of muriate of soda. I then applied one extremity of the arc to the most distant part of the probe, and the other to the surface of the water, by which means the Galvanism was made to exercise its action without any immediate contact of the animal parts. When this arrangement was formed, the arm, which hung over the edge of the table, moved towards the breast, passing over the space of about a foot and a half. By employing, at the same time, the two piles composed of a hundred plates of copper and zinc, the contractions were much increased. But this augmentation of force did not exactly follow the ratio of the combined activity of the two piles united.
EXPERIMENT L.
By forming an arc from the feet to the spinal marrow, first applying armatures, and then employing a solution of muriate of soda as in the preceding experiments, I obtained contractions, but weaker than those in the upper extremities. As there was reason to suspect that this diminution arose in part from the position of the trunk, I placed the body in such a manner, that, while the thighs rested on the edge of the table, the legs, which hung over it, were at full liberty to move. This difference in position produced a difference in the results; and I intend to repeat the experiment, according to this arrangement, applying the arc directly to the crural nerves.
EXPERIMENT LI.
A small portion of the great pectoral muscle being detached from the ribs, and exposed to the action of the pile, exhibited strong contractions, and the motion of the diaphragm was also very remarkable. The heart alone, though carefully subjected to all the operations detailed in the 47th experiment, remained perfectly motionless.
EXPERIMENT LII.
Having brought the separated head near to the neck of the trunk, I established a communication between it and the trunk by means of the animal moisture alone; and an arc being then formed from the head to different parts of the trunk, sensible contractions were produced, and particularly in the latter. This observation seems still further to prove that an arc of moisture has power to excite muscular contractions. In this, as well as in the preceding experiments, if any of the spectators, while an arc was established by means of the pile, brought a frog prepared in the usual manner near to the human body, the frog experienced strong contractions, though at a distance from the place to which the action of the Galvanism was determined.
EXPERIMENT LIII.
After three hours had been employed in these experiments, I conceived the idea of trying the action of Galvanism on some parts of the body separated from the trunk. One of the legs, therefore, was amputated six inches above the joint of the knee; and an arc being established from a point in the plane of the section to the knee, I obtained contractions similar to those which had been produced before the limb was separated from the body. I then formed an arc of moisture, by applying the amputated limb to the trunk; and having determined the action of the pile to the spinal marrow and the foot, I obtained very sensible contractions. I observed, on this occasion, that a frog, prepared some time before, and which was accidentally lying on the table, at each application of the metallic arcs moved like an electrometer, and thus confirmed the action of an arc of moisture.
EXPERIMENT LIV.
After a considerable time had been employed in the preceding experiment, I endeavoured to revive the action of the Galvanism by moistening the muscles with a solution of opium. By these means the contractions seemed to be increased; and the case was the same in other warm-blooded animals. A series of similar experiments, if carefully made, would no doubt be attended with important results; as they might enable us to ascertain the action of the different stimulants proposed by Dr. Brown. But I must, in the mean time, observe, that the before-mentioned effects of opium fully correspond with those long ago observed by Galvani.
It results, in general, from my experiments, that moisture performs a conspicuous part in producing contractions; and that it is even of more importance than animal heat. I indeed find that muscular contractions may be obtained after the body has thrown out a great deal of its heat, even when it has cooled for several hours, and when it has been exposed to a temperature below zero; for, if Galvanism be communicated to a body in that state, muscular contractions will be immediately excited; but they soon cease by the privation of animal moisture. If a muscle, indeed, which has been laid bare resists the Galvanic influence, its action may be speedily renewed by making an incision into it, or into some of the muscles which surround it. I can assert, that by this process partial contractions were produced in the human body five hours after death, every time that the arcs were applied to the muscular fibres.
Being worn out with this long series of experiments, I found it necessary to abandon them; but, from the force of the contractions, it could easily be seen that they might have been produced much longer.
Having communicated these results to the celebrated Caldani, Professor of Anatomy in the University of Padua, he requested that I would confirm the observations I had made by again applying Galvanism to the membranes and to the cortical substance of the brain. He was unwilling to give up the system of Haller without very positive proofs; and his doubts were to me of great utility, as they induced me to establish the action of Galvanism on these parts by the following experiments:
EXPERIMENT LV.
As these doubts related to a delicate point, which would have produced some variation in the theory of a celebrated physiologist, I repeated the experiment on the head of an ox newly killed, in the presence of Professor Mondini, who made the necessary preparations. The dura mater was laid bare; and the action of the Galvanism being conducted to it, strong contractions were immediately produced. The same phænomenon took place when the cortical substance was brought into contact with one of the arcs. I repeated this experiment with the same success on the heads of several oxen and lambs.
EXPERIMENT LVI.
When I passed through Turin, Professors Vassalli, Giulio, and Rossi requested me to perform, in their presence, my principal experiments, and those in particular which related to the membranes and the cortical substance of the brain. They observed, at the same time, that in uncovering the brain of an ox with a cleaver, some derangement, in consequence of the agitation, might be effected in that organ, which would perhaps produce an alteration in the results. Professors Giulio and Rossi proposed therefore to uncover the brain by the trepan, which gave a greater degree of precision to the experiment. The dura mater of an ox being uncovered in this manner, it was subjected to the action of Galvanism, and even with this mode of preparation the muscular contractions every time the arc was applied were pretty strong. The arc being determined to the cortical substance, the force of the contractions seemed to be increased; and in general they appeared to be more considerable in proportion as the arc was plunged to a greater depth into the substance of the brain.
These gentlemen, in whose presence I performed my principal experiments, having pursued my method after my departure, made some observations which may be of great use to physiology. They had before entertained strong doubts whether the heart was susceptible of the Galvanic action, by means of simple armatures applied to the different parts of that muscle; and such irregularity had been observed in the results, that it appeared difficult to determine the question. I was therefore exceedingly happy that I had had an opportunity of exciting in others a desire to make new researches in regard to this point, of so much importance. Professors Vassalli, Giulio and Rossi repeated and modified my experiments on the heart in such a manner, that they obtained in man, and warm-blooded animals, contractions similar to those which I had observed only in cold-blooded animals. I wait for a detailed account of these experiments, as well as of others made on decapitated criminals[2], which were subjected to my processes. The bodies were removed to the large hospital; and notwithstanding the long period which had elapsed between the time of the execution and that when the experiments were performed, they observed almost the same phænomena.
The observation made on this criminal, that the vital powers exist so long in the body after death, induces me to hope that I shall be able to obtain similar results by the application of my method, in common cases of suspended animation. But when employed for this laudable purpose it should be modified in such a manner as to render unnecessary those operations which are so painful to humanity. On this account, I have invented a method by which muscular contractions may be produced without the least incision or separation of the muscles. It is so combined, that it cannot be rejected by the most rigorous medical jurisprudence.
[2] Some account of the latter, from the _Journal de Physique_, will be found in the Appendix.—TRANS.
EXPERIMENT LVII.
In order to try the vital force existing in the human body after death, I immerse the hand in a solution of muriate of soda, and establish an arc, one of the extremities of which is made to pass round the fore-arm, while the other is brought into contact with the bottom of the pile. I adapt to the extremity of another arc an elastic probe, which is applied to one of the ears, moistened by means of a syringe with the same solution, and connect the other extremity of the arc with the summit of the pile. By this arrangement various contractions, according to the different degrees of vitality in the bodies, are observed, sometimes in the fingers, sometimes in the hand, and sometimes in the whole arm. The fingers bend, and move in a sensible manner; and sometimes the whole of the fore-arm proceeds towards the breast. The importance of this method for determining the duration of the vital powers after death may be readily comprehended. Should means be found hereafter to make further discoveries in regard to this interesting point, physiologists may then be able to determine with certainty those cases when interment ought to be retarded; and those where the good of society requires that every possible means of resuscitation should be employed. In the large hospital of Bologna, I made several observations on this subject; and remarked in particular, how much the nature of the disease contributes, _cæteris paribus_, to produce a difference in the duration of the muscular contractions. I tried the case of death produced by putrid fevers, by pleurisies, by wounds in the pericardium, by the scurvy, and by the consequences of parturition; and I found a great difference in the degrees of vitality, according to the circumstances of the disease, the age and temperament of the individual; which confirms me in the opinion I entertain, that these experiments, if long continued without intermission by able physiologists, might be of the greatest benefit to medicine.
These researches are not an object of mere curiosity; they seem to open an extensive field for promoting the welfare of the human race, and may be of service in cases of apparent death, occasioned by an alteration of the brain, and sometimes in cases of asphyxia. Various learned academies are entitled to great praise for having turned their attention to this subject, and for having already recommended different stimulants as proper for being used on such occasions. But I must take the liberty of requesting that in similar cases the action of Galvanism maybe tried, by employing the new method here proposed. It is of great importance that the means of affording relief to the sufferings of mankind should be multiplied, and especially in cases in which the old system of medicine presents to us so few resources. In the mean time I conceive it may be useful to make some trials on animals thrown into a state of asphyxia different ways. These researches may lead to valuable discoveries, and produce some light to direct us in our attempts to save the lives of men. If the encouragement I have received from the medical and philosophical world, in general, induce others to pursue the same path, it will give me great satisfaction. Galvanism is yet in its infancy; and when we reflect on the slow progress which many other branches of science have made, and how long they remained almost stationary before the full importance of them was known, it would be presumption to set bounds to that which is the subject of the present work. For my part, I spared no pains during my short stay at Paris to exhibit my method, and to make it publicly known. Dr. Pinel assisted at my experiments with the utmost zeal, and was witness to muscular contractions excited in the body of an old woman, who had died of a malignant putrid fever. The interest which he took in my researches induced me to communicate to him several plans I had formed for giving relief to some of those unfortunate beings committed to his skill and beneficent care in the _Hôpital des Foux_. I pointed out to him some particular cases where the individuals, in consequence of a deep rooted melancholy, were reduced almost to a state of idiotism, and in which Galvanism seemed likely to be attended with the greatest benefit. In the last public sitting of the Institute of Bologna, at which I was present, I announced the complete cure of two lunatics performed in the Public Hospital, in the presence of many of the medical pupils, and with the assistance of the professors who superintend that establishment, and who are now employed in confirming my method on other patients. I am well aware that two cures are not sufficient to make operations of this kind be admitted as general remedies; but they ought to encourage physicians to prosecute this subject in order to ascertain how far Galvanism can be considered as of utility in such cases, and to endeavour by their labours to fill up the vacuity which still exists in this part of medicine. I am ready to acknowledge that great caution ought to be employed in performing such experiments; and for this reason I purpose, in the third part of the present work, to lay before the reader the reflections and observations of various ingenious men who have made this department of Galvanism an object of their researches.
But before I proceed further, I think it necessary to deduce from what has been already said a few general corollaries.
COROLLARY I.
The muscles are affected by the action of the pile in a much more powerful manner when they are laid entirely bare, and when the arc is made to penetrate to a considerable depth in their substance.
COROLLARY II.
These convulsions are increased in proportion to the number of the points of contact between the arc and the muscle.
COROLLARY III.
In many cases, muscular contractions are obtained by forming an arc from one muscle to another.
COROLLARY IV.
Muscular contractions are almost always speedily obtained by the pile, even when the means proposed by Haller fail to produce them.
COROLLARY V.
The heart, which, according to Haller’s principle, is the first muscle that receives life and the last to lose it, in comparison of the other muscles, can with difficulty be made to feel the influence of the Galvanic action; while the other muscles always retain, a long time after death, that vital force which it has never been found possible to excite but by the impulse of Galvanism.
COROLLARY VI.
The partisans of Haller, to excite these contractions, often employ stimulants, which alter the texture of the muscular fibre, and destroy its continuity; an inconvenience which may be avoided by applying Galvanism.
COROLLARY VII.
As the kinds of apparatus before mentioned are not applied to the spinal marrow alone, but to the different nerves of the animal machine, they may afford to the anatomist an experimental myology; by means of which he can render sensible to the eye the fixed and moveable points of the muscles, and the real extent of their action.
COROLLARY VIII.
The experiments made on the bodies of persons who died a natural death, are of the greatest importance to physiology. I am strongly inclined to think that, by pursuing these researches more in detail, they will one day make us better acquainted with the character of the vital powers, and the difference of their duration, according to diversity of sex, age, temperament and disease, and even according to diversity of climate and to the nature of the atmosphere.
PART THE THIRD.
ON THE POWER OF GALVANISM AS APPLIED TO MEDICINE.
If the doctrine of Galvanism have thrown considerable light on various parts of philosophy and chemistry, it gives us reason to hope that it may also be of benefit to medicine. The labours indeed of Galvani, whose most ardent desire was that his discovery might be rendered useful to mankind, were at length directed to this object, and his wishes now begin to be realized; but I must request the reader not to be too sanguine in his expectations, or to imagine that I here mean to entertain him with a long series of wonderful or extraordinary cures performed by means of Galvanism. I have no intention to decorate the discovery of my late uncle with false glory. Though I possess neither the same depth of knowledge, nor the same superiority of talents, I have always endeavoured to imitate his moderation and prudence in the application of his theory. I am fully convinced that much still remains to be done, in order to discover the best methods of employing this new agent; and that the facts respecting it, though numerous, have not been reduced to principles sufficiently certain and satisfactory. There are, nevertheless, some results and observations exceedingly curious, which, if confirmed by new experiments and researches, may enable us to obtain convincing proofs of its utility. New facts, however surprising, are not to be despised merely on account of their being different from any before observed. Those who reject them, as some have done, ought first to show that they are inconsistent with the principles of sound philosophy. Guided by these reflections, and desirous of contributing, as far as possible, towards the illustration of a new and very obscure subject, I shall lay before the reader the result of my researches in the following articles.
SECTION I.
_Advantages which the medical administration of Galvanism has over that of common electricity._